PMID- 35525219
OWN - NLM
STAT- MEDLINE
DCOM- 20220623
LR  - 20220624
IS  - 1873-3336 (Electronic)
IS  - 0304-3894 (Linking)
VI  - 436
DP  - 2022 Aug 15
TI  - The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe 
      QDs-induced inflammation in macrophage.
PG  - 129043
LID - S0304-3894(22)00832-9 [pii]
LID - 10.1016/j.jhazmat.2022.129043 [doi]
AB  - Cadmium telluride quantum dots (CdTe QDs) exist in the environment due to the 
      abandonment of products. There is a potential risk to organisms and toxic 
      mechanism is worth exploring. In this study, 12.5 mumol/Kg body weight CdTe QDs 
      triggered systemic and local inflammatory response in mice and activated 
      macrophages, then the mechanism of activating macrophages to overexpress IL-1beta 
      and IL-6 was explored. RAW264.7 macrophages were used, and after macrophages 
      exposing to 1 muM CdTe QDs for 24 h, oxidative stress occurred. Further 
      investigation found that CdTe QDs triggered ferroptosis in RAW264.7 cells. And 
      deferoxamine mesylate alleviated the excessive lipid hydroperoxide caused by QDs. 
      Mechanistically, CdTe QDs-provoked decrease of nuclear factor erythroid 2-related 
      factor 2 (NRF2) elicited phosphorylation of extracellular regulated protein 
      kinases1/2 (ERK1/2) and then activated ferritinophagy, which made ferritin heavy 
      chain 1 (FTH1) degraded in lysosome and proteasome to release free iron ions to 
      initiate ferroptosis in macrophages. This paper updates the mechanism of 
      macrophage activation by CdTe QDs with regard to ferritinophagy, and more 
      importantly, identifies the key role of NRF2 and ERK1/2. Our research extends the 
      role of ferroptosis in inflammatory responses triggered by nanoparticles (NPs) in 
      macrophages and provides insightful reference for toxicity assessment of NPs.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Liu, Na
AU  - Liu N
AD  - Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, PR China.
FAU - Liang, Ying
AU  - Liang Y
AD  - Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, PR China; Testing 
      Center for Medical Device, Yancheng Institute of Measurement and Testing, 
      Yancheng 224007, PR China.
FAU - Wei, Tingting
AU  - Wei T
AD  - Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, PR China.
FAU - Zou, Lingyue
AU  - Zou L
AD  - Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, PR China.
FAU - Huang, Xiaoquan
AU  - Huang X
AD  - Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, PR China.
FAU - Kong, Lu
AU  - Kong L
AD  - Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, PR China.
FAU - Tang, Meng
AU  - Tang M
AD  - Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, PR China. 
      Electronic address: tm@seu.edu.cn.
FAU - Zhang, Ting
AU  - Zhang T
AD  - Key Laboratory of Environmental Medicine & Engineering, Ministry of Education, 
      School of Public Health, Southeast University, Nanjing 210009, PR China. 
      Electronic address: zhangting@seu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220504
PL  - Netherlands
TA  - J Hazard Mater
JT  - Journal of hazardous materials
JID - 9422688
RN  - 0 (Cadmium Compounds)
RN  - 0 (NF-E2-Related Factor 2)
RN  - NQA0O090ZJ (Tellurium)
RN  - STG188WO13 (cadmium telluride)
SB  - IM
MH  - Animals
MH  - *Cadmium Compounds/toxicity
MH  - *Ferroptosis
MH  - Inflammation/chemically induced
MH  - Macrophages/metabolism
MH  - Mice
MH  - NF-E2-Related Factor 2/genetics/metabolism
MH  - *Quantum Dots/toxicity
MH  - Tellurium/toxicity
OTO - NOTNLM
OT  - CdTe QDs
OT  - Ferritinophagy
OT  - Ferroptosis
OT  - Inflammation
OT  - Toxicity
EDAT- 2022/05/08 06:00
MHDA- 2022/06/24 06:00
CRDT- 2022/05/07 18:26
PHST- 2022/02/16 00:00 [received]
PHST- 2022/04/11 00:00 [revised]
PHST- 2022/04/27 00:00 [accepted]
PHST- 2022/05/08 06:00 [pubmed]
PHST- 2022/06/24 06:00 [medline]
PHST- 2022/05/07 18:26 [entrez]
AID - S0304-3894(22)00832-9 [pii]
AID - 10.1016/j.jhazmat.2022.129043 [doi]
PST - ppublish
SO  - J Hazard Mater. 2022 Aug 15;436:129043. doi: 10.1016/j.jhazmat.2022.129043. Epub 
      2022 May 4.