PMID- 35525711
OWN - NLM
STAT- MEDLINE
DCOM- 20220614
LR  - 20220621
IS  - 1879-1166 (Electronic)
IS  - 0198-8859 (Linking)
VI  - 83
IP  - 7
DP  - 2022 Jul
TI  - HLA class I chain-related MICA and MICB genes polymorphism in healthy individuals 
      from the Bulgarian population.
PG  - 551-555
LID - S0198-8859(22)00087-8 [pii]
LID - 10.1016/j.humimm.2022.04.006 [doi]
AB  - Although human leukocyte antigen (HLA) gene polymorphism has been investigated in 
      many populations around the world, the data on MHC class I chain-related (MIC) 
      genes are still limited. The present study is aimed to analyze the allelic 
      polymorphism of MICA and MICB genes and haplotype associations with HLA-B locus 
      in 132 healthy, unrelated individuals from the Bulgarian population by next 
      generation sequencing (NGS). A total of 36 MICA and 16 MICB alleles were observed 
      with the highest frequency detected for MICA*008:01 (17.1%) and MICB*005:02 
      (32.4%). Further, two and three-loci haplotype frequencies and pairwise linkage 
      disequilibrium were estimated. Highly significant global linkage disequilibrium 
      was found between either HLA-B and MICA and MICB genes. This is the first study 
      on MICA and MICB allelic polymorphism, linkage disequilibrium, and haplotype 
      polymorphism in the Bulgarian population. These results will allow for better 
      characterization of the genetic heterogeneity of the Bulgarian population and 
      could contribute to further analyses on MICA and MICB clinical significance.
CI  - Copyright (c) 2022 American Society for Histocompatibility and Immunogenetics. 
      Published by Elsevier Inc. All rights reserved.
FAU - Al Hadra, Bushra
AU  - Al Hadra B
AD  - Department of Clinical Immunology, Medical University, Sofia, Bulgaria; 
      Department of Clinical Immunology and Stem Cell Bank, Alexandrovska University 
      Hospital, Sofia, Bulgaria. Electronic address: bushraalkhadra@gmail.com.
FAU - Lukanov, Tsvetelin I
AU  - Lukanov TI
AD  - Department of Clinical Immunology, Medical University, Sofia, Bulgaria; 
      Department of Clinical Immunology and Stem Cell Bank, Alexandrovska University 
      Hospital, Sofia, Bulgaria.
FAU - Ivanova, Milena I
AU  - Ivanova MI
AD  - Department of Clinical Immunology, Medical University, Sofia, Bulgaria; 
      Department of Clinical Immunology and Stem Cell Bank, Alexandrovska University 
      Hospital, Sofia, Bulgaria.
LA  - eng
PT  - Journal Article
DEP - 20220505
PL  - United States
TA  - Hum Immunol
JT  - Human immunology
JID - 8010936
RN  - 0 (HLA-B Antigens)
RN  - 0 (Histocompatibility Antigens Class I)
RN  - 0 (MHC class I-related chain A)
RN  - 0 (MICB antigen)
SB  - IM
MH  - Alleles
MH  - Bulgaria
MH  - Gene Frequency
MH  - HLA-B Antigens/genetics
MH  - Haplotypes
MH  - *Histocompatibility Antigens Class I/genetics
MH  - Humans
MH  - Linkage Disequilibrium
MH  - Polymorphism, Genetic
OTO - NOTNLM
OT  - Bulgarians
OT  - Linkage disequilibrium
OT  - MICA
OT  - MICB
OT  - Polymorphism
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2022/05/08 06:00
MHDA- 2022/06/15 06:00
CRDT- 2022/05/07 22:05
PHST- 2022/01/12 00:00 [received]
PHST- 2022/04/01 00:00 [revised]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/05/08 06:00 [pubmed]
PHST- 2022/06/15 06:00 [medline]
PHST- 2022/05/07 22:05 [entrez]
AID - S0198-8859(22)00087-8 [pii]
AID - 10.1016/j.humimm.2022.04.006 [doi]
PST - ppublish
SO  - Hum Immunol. 2022 Jul;83(7):551-555. doi: 10.1016/j.humimm.2022.04.006. Epub 2022 
      May 5.