PMID- 35526475
OWN - NLM
STAT- MEDLINE
DCOM- 20220628
LR  - 20220705
IS  - 2211-0356 (Electronic)
IS  - 2211-0348 (Linking)
VI  - 63
DP  - 2022 Jul
TI  - Fatigue and brain atrophy in Egyptian patients with relapsing remitting multiple 
      sclerosis.
PG  - 103841
LID - S2211-0348(22)00353-4 [pii]
LID - 10.1016/j.msard.2022.103841 [doi]
AB  - BACKGROUND: Fatigue is the most troublesome symptom in relapsing remitting 
      multiple sclerosis (RRMS). It starts early in the disease course, escalates with 
      disease progression and impacts the patients; quality of life. The aim of this 
      work was to estimate the frequency of fatigue and to evaluate the relationship 
      between severity of fatigue, clinical data, level of disability and volumetric 
      brain atrophy in RRMS. METHODS: 43 RRMS patients with 40 age- and sex-matched 
      normal volunteers were recruited. Demographic and clinical data were recorded. 
      Each participant was assessed with the Expanded Disability Status Scale (EDSS), 
      Fatigue Severity Scale (FSS), Brief Cognitive Assessment for Multiple Sclerosis 
      (BICAMS) and a variety of brain volumetric measures. RESULTS: 31 (72.1%) of RRMS 
      patients were found to have fatigue. There were no significant differences in 
      demographic data between patients with or without fatigue according to FSS. 
      However, patients with fatigue had a higher number of attacks, and higher scores 
      in the EDSS and BICAMS than non-fatigued patients. There was a greater reduction 
      in total brain volume, cerebral grey matter, and brain stem, thalamic and caudate 
      volumes in fatigued compared with the non-fatigued patients and controls. FSS was 
      significantly correlated with patients' age, duration of illness, total number of 
      attacks, EDSS, and BICAMS. Total brain, cerebral grey matter and thalamic volumes 
      all had negative correlations with fatigue severity. Regression analysis showed 
      that EDSS accounted for 46% of the variance in fatigue scores while thalamic and 
      brainstem atrophy accounted for 50.7%. CONCLUSION: Fatigue was fairly common in 
      RRMS patients. Level of disability and atrophy of the thalamus and brain stem 
      were the best predictors of fatigue.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Khedr, Eman M
AU  - Khedr EM
AD  - Department of Neuropsychiatry, Faculty of Medicine, Assiut University Hospital, 
      Assiut, Egypt; Neuropsychiatric Department, Faculty of Medicine, Aswan University 
      Hospital, Aswan, Egypt. Electronic address: emankhedr99@yahoo.com.
FAU - Desoky, Tarek
AU  - Desoky T
AD  - Neuropsychiatric Department, Faculty of Medicine, South Valley University, Qena 
      University Hospital, Qena, Egypt.
FAU - Gamea, Ayman
AU  - Gamea A
AD  - Neuropsychiatric Department, Faculty of Medicine, South Valley University, Qena 
      University Hospital, Qena, Egypt.
FAU - Ezzeldin, Mohammed Y
AU  - Ezzeldin MY
AD  - Neuropsychiatric Department, Faculty of Medicine, South Valley University, Qena 
      University Hospital, Qena, Egypt.
FAU - Zaki, Ahmed F
AU  - Zaki AF
AD  - Neuropsychiatric Department, Faculty of Medicine, South Valley University, Qena 
      University Hospital, Qena, Egypt.
LA  - eng
PT  - Journal Article
DEP - 20220502
PL  - Netherlands
TA  - Mult Scler Relat Disord
JT  - Multiple sclerosis and related disorders
JID - 101580247
SB  - IM
MH  - Atrophy/pathology
MH  - *Brain/pathology
MH  - Case-Control Studies
MH  - Disease Progression
MH  - Egypt/epidemiology
MH  - *Fatigue/epidemiology
MH  - Female
MH  - Humans
MH  - Male
MH  - *Multiple Sclerosis, Relapsing-Remitting/epidemiology/pathology
MH  - Severity of Illness Index
OTO - NOTNLM
OT  - BICAMS
OT  - Brain atrophy
OT  - Cognitive impairment
OT  - EDSS
OT  - Fatigue
OT  - Grey matter atrophy
OT  - Magnetic resonance imaging
OT  - Thalamus
EDAT- 2022/05/09 06:00
MHDA- 2022/06/29 06:00
CRDT- 2022/05/08 18:15
PHST- 2021/12/07 00:00 [received]
PHST- 2022/04/29 00:00 [revised]
PHST- 2022/04/30 00:00 [accepted]
PHST- 2022/05/09 06:00 [pubmed]
PHST- 2022/06/29 06:00 [medline]
PHST- 2022/05/08 18:15 [entrez]
AID - S2211-0348(22)00353-4 [pii]
AID - 10.1016/j.msard.2022.103841 [doi]
PST - ppublish
SO  - Mult Scler Relat Disord. 2022 Jul;63:103841. doi: 10.1016/j.msard.2022.103841. 
      Epub 2022 May 2.