PMID- 35531577 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2517-729X (Print) IS - 2517-729X (Electronic) IS - 2517-729X (Linking) VI - 35 IP - 2 DP - 2022 TI - Different patterns of association between white matter microstructure and plasma unsaturated fatty acids in those with high risk for psychosis and healthy participants. PG - e100703 LID - 10.1136/gpsych-2021-100703 [doi] LID - e100703 AB - BACKGROUND: Disrupted white matter (WM) microstructure has been commonly identified in youth at clinical high risk (CHR) for psychosis. Several lines of evidence suggest that fatty acids, especially unsaturated fatty acids (UFAs), might play a crucial role in the WM pathology of early onset psychosis. However, evidence linking UFA and WM microstructure in CHR is quite sparse. AIMS: We investigated the relationship between the plasma UFA level and WM microstructure in CHR participants and healthy controls (HC). METHODS: Plasma fatty acids were assessed and diffusion tensor imaging (DTI) data were performed with tract-based spatial statistics (TBSS) analysis for 66 individuals at CHR for psychosis and 70 HC. RESULTS: Both the global and regional diffusion measures showed significant between-group differences, with decreased fractional anisotropy (FA) but increased mean diffusivity (MD) and radial diffusivity (RD) found in the CHR group compared with the HC group. On top of that, we found that in the HC group, plasma arachidic acid showed obvious trend-level associations with higher global FA, lower global MD and lower global RD, which regionally spread over the corpus callosum, right anterior and superior corona radiata, bilateral anterior and posterior limb of the internal capsule, and bilateral superior longitudinal fasciculus. However, there were no associations between global WM measures and any UFA in the CHR group. Conversely, we even found negative associations between arachidic acid levels and regional FA values in the right superior longitudinal fasciculus and right retrolenticular part of the internal capsule in the CHR group. CONCLUSIONS: Compared with the HC group, CHR subjects exhibited a different pattern of association between WM microstructure and plasma UFA, with a neuroprotective effect found in the HC group but not in the CHR group. Such discrepancy could be due to the excessively upregulated UFAs accumulated in the plasma of the CHR group, highlighting the role of balanced plasma-membrane fatty acids homeostasis in WM development. CI - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ. FAU - Su, Wenjun AU - Su W AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Li, Zhixing AU - Li Z AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Xu, Lihua AU - Xu L AUID- ORCID: 0000-0002-2237-9336 AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zeng, Jiahui AU - Zeng J AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Tang, Yingying AU - Tang Y AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Tang, Xiaochen AU - Tang X AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wei, Yanyan AU - Wei Y AUID- ORCID: 0000-0002-8218-1954 AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Guo, Qian AU - Guo Q AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Zhang, Tianhong AU - Zhang T AUID- ORCID: 0000-0002-5379-7119 AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. FAU - Wang, Jijun AU - Wang J AD - Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China. AD - CAS Center for Excellence in Brain Science and Intelligence Technology (CEBSIT), Chinese Academy of Science, Shanghai, China. AD - Institute of Psychology and Behavioral Science, Shanghai Jiao Tong University, Shanghai, China. LA - eng PT - Journal Article DEP - 20220413 PL - England TA - Gen Psychiatr JT - General psychiatry JID - 101735271 PMC - PMC9014058 OTO - NOTNLM OT - schizophrenia COIS- Competing interests: None declared. EDAT- 2022/05/10 06:00 MHDA- 2022/05/10 06:01 PMCR- 2022/04/13 CRDT- 2022/05/09 04:36 PHST- 2021/12/06 00:00 [received] PHST- 2022/03/07 00:00 [accepted] PHST- 2022/05/09 04:36 [entrez] PHST- 2022/05/10 06:00 [pubmed] PHST- 2022/05/10 06:01 [medline] PHST- 2022/04/13 00:00 [pmc-release] AID - gpsych-2021-100703 [pii] AID - 10.1136/gpsych-2021-100703 [doi] PST - epublish SO - Gen Psychiatr. 2022 Apr 13;35(2):e100703. doi: 10.1136/gpsych-2021-100703. eCollection 2022.