PMID- 35532646
OWN - NLM
STAT- MEDLINE
DCOM- 20220511
LR  - 20220511
IS  - 1998-4022 (Electronic)
IS  - 0028-3886 (Linking)
VI  - 70
IP  - 2
DP  - 2022 Mar-Apr
TI  - Cerebrospinal Fluid Procalcitonin-A Potential Biomarker for Post-Craniotomy 
      Bacterial Meningitis.
PG  - 721-726
LID - 10.4103/0028-3886.344643 [doi]
AB  - BACKGROUND: The literature regarding the utility of cerebrospinal fluid (CSF) 
      procalcitonin (PCT) in the diagnosis of post-craniotomy bacterial meningitis and 
      differentiating it from aseptic meningitis is sparse. MATERIALS AND METHODS: CSF 
      total WBC count, sugar, protein, and PCT were measured in febrile patients with 
      suspected post-craniotomy meningitis during the first 30 days following an 
      intradural cranial procedure for non-trauma indications. Patients were diagnosed 
      as postoperative bacterial meningitis if CSF culture was positive (PBM, n = 28) 
      or postoperative aseptic meningitis if CSF culture was sterile and there was no 
      evidence of systemic infection (PAM, n = 31). CSF cytochemical parameters and PCT 
      values were compared between the groups. Normal values of CSF PCT were obtained 
      from 14 patients with noninfectious indications with hydrocephalus. RESULTS: 
      There was no significant difference in CSF total WBC count, sugar, and protein 
      levels between PAM and PBM groups. The median PCT level in CSF in the normal 
      group was 0.03 ng/mL (interquartile range [IQR] 0.02-0.07 ng/mL). CSF PCT in the 
      PBM group (median 0.37 ng/mL, IQR 0.2-1.4 ng/mL) was significantly higher than 
      normal values as well as PAM group (median 0.12 ng/mL, IQR 0.07-0.26 ng/mL (P = 
      0.0004). The area under the receiver operating characteristic (ROC) curve for CSF 
      PCT was 0.767. A cutoff value of 0.12 ng/mL yielded a sensitivity of 85.7% (95% 
      CI: 67.3% to 96%), specificity of 51.6% (95% CI: 33% to 69.9%), positive 
      predictive value of 61.5% (95% CI: 51.9% to 70.3%), and negative predictive value 
      of 80% (95% CI: 60.3.8% to 91.3%). CONCLUSIONS: CSF PCT assay in patients who are 
      febrile during the first 30 days post-non-trauma neurosurgical procedures has a 
      role in the early diagnosis of bacterial meningitis.
FAU - Moorthy, Ranjith K
AU  - Moorthy RK
AD  - Department of Neurological Sciences, Christian Medical College, Vellore, Tamil 
      Nadu, India.
FAU - Job, Victoria
AU  - Job V
AD  - Department of Clinical Biochemistry, Christian Medical College, Vellore, Tamil 
      Nadu, India.
FAU - Rebekah, Grace
AU  - Rebekah G
AD  - Department of Biostatistics, Christian Medical College, Vellore, Tamil Nadu, 
      India.
FAU - Rajshekhar, Vedantam
AU  - Rajshekhar V
AD  - Department of Neurological Sciences, Christian Medical College, Vellore, Tamil 
      Nadu, India.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neurol India
JT  - Neurology India
JID - 0042005
RN  - 0 (Biomarkers)
RN  - 0 (Procalcitonin)
RN  - 0 (Sugars)
RN  - 9007-12-9 (Calcitonin)
SB  - IM
MH  - Biomarkers/cerebrospinal fluid
MH  - Calcitonin/cerebrospinal fluid
MH  - Craniotomy
MH  - Disease Progression
MH  - Fever
MH  - Humans
MH  - *Meningitis, Aseptic
MH  - *Meningitis, Bacterial/cerebrospinal fluid/diagnosis
MH  - Procalcitonin/cerebrospinal fluid
MH  - Prospective Studies
MH  - ROC Curve
MH  - Sugars
OTO - NOTNLM
OT  - Aseptic meningitis
OT  - bacterial meningitis
OT  - biomarkers
OT  - postoperative fever
OT  - postoperative meningitis
OT  - procalcitonin
COIS- None
EDAT- 2022/05/10 06:00
MHDA- 2022/05/12 06:00
CRDT- 2022/05/09 10:59
PHST- 2022/05/09 10:59 [entrez]
PHST- 2022/05/10 06:00 [pubmed]
PHST- 2022/05/12 06:00 [medline]
AID - ni_2022_70_2_721_344643 [pii]
AID - 10.4103/0028-3886.344643 [doi]
PST - ppublish
SO  - Neurol India. 2022 Mar-Apr;70(2):721-726. doi: 10.4103/0028-3886.344643.