PMID- 35533425
OWN - NLM
STAT- MEDLINE
DCOM- 20220816
LR  - 20220906
IS  - 1879-0739 (Electronic)
IS  - 0271-5317 (Linking)
VI  - 104
DP  - 2022 Aug
TI  - Quamoclit angulata extract supplementation attenuates hepatic damage via 
      regulation of AMPK/SIRT associated hepatic lipid metabolism in streptozotocin and 
      high fat diet-induced T2DM mice.
PG  - 10-19
LID - S0271-5317(22)00028-8 [pii]
LID - 10.1016/j.nutres.2022.03.012 [doi]
AB  - Quamoclit angulata (QA) is a species of the Convolvulaceae family and has a 
      regulatory effect on glucose homeostasis. However, the effects of QA on 
      hyperglycemia-induced hepatic damage has not been elucidated. We hypothesized 
      that QA extract (QAE) would alleviate hepatic damage through regulation of 
      hepatic lipid accumulation in type 2 diabetes mellitus (T2DM). T2DM was induced 
      by streptozotocin-high-fat diet in C57BL6 male mice for 8 weeks. The diabetic 
      mice were supplemented with QAE at low dose (5 mg/kg) or high dose (HQ, 10 mg/kg) 
      by oral gavage every day for 12 weeks. Histopathological changes in hepatic 
      tissue were examined using hematoxylin and eosin staining, and the protein levels 
      of biomarkers related to AMP-activation kinase (AMPK)/sirtuin-1 
      (SIRT1)-associated lipid metabolism were measured using Western blotting. QAE 
      supplementation ameliorated plasma insulin and glycated hemoglobin in diabetic 
      mice. Furthermore, QAE decreased hepatic lipid accumulation demonstrated by 
      hepatic triglyceride and cholesterol levels. QAE supplementation induced hepatic 
      AMPK, which activates SIRT1 accompanied by reduced lipogenesis in the HQ group. 
      These changes were partially explained by the amelioration of advanced glycation 
      end product, hepatic oxidative stress, inflammation, and fibrosis in diabetic 
      mice. Altogether, QAE would be a potential nutraceutical to prevent hepatic 
      damage by regulation of AMPK/SIRT1-associated lipid metabolism through oxidative 
      stress, inflammation, and fibrosis in T2DM.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Lee, Heaji
AU  - Lee H
AD  - Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Korea.
FAU - Kim, Younmi
AU  - Kim Y
AD  - Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Korea.
FAU - Kim, Sun Yeou
AU  - Kim SY
AD  - Gachon Institute of Pharmaceutical Science, Gachon University, 191 Hambakmoero, 
      Yeonsu-gu, Incheon, 406-799, Republic of Korea.
FAU - Lim, Yunsook
AU  - Lim Y
AD  - Department of Food and Nutrition, Kyung Hee University, Seoul 02447, Korea. 
      Electronic address: ylim@khu.ac.kr.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220327
PL  - United States
TA  - Nutr Res
JT  - Nutrition research (New York, N.Y.)
JID - 8303331
RN  - 0 (Plant Extracts)
RN  - 0 (Triglycerides)
RN  - 5W494URQ81 (Streptozocin)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - EC 3.5.1.- (Sirtuin 1)
SB  - IM
MH  - AMP-Activated Protein Kinases/metabolism
MH  - Animals
MH  - *Diabetes Mellitus, Experimental/complications/drug therapy
MH  - *Diabetes Mellitus, Type 2/complications/metabolism
MH  - Diet, High-Fat/adverse effects
MH  - Dietary Supplements
MH  - Fibrosis
MH  - Inflammation/metabolism
MH  - Lipid Metabolism
MH  - *Liver/metabolism/physiopathology
MH  - Male
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Plant Extracts/pharmacology
MH  - Sirtuin 1/metabolism
MH  - Streptozocin
MH  - Triglycerides/metabolism
OTO - NOTNLM
OT  - Energy metabolism
OT  - Fatty liver
OT  - Lipid metabolism
OT  - Quamoclit angulata
OT  - Type 2 diabetes mellitus
EDAT- 2022/05/10 06:00
MHDA- 2022/08/17 06:00
CRDT- 2022/05/09 18:14
PHST- 2021/10/26 00:00 [received]
PHST- 2022/03/21 00:00 [revised]
PHST- 2022/03/22 00:00 [accepted]
PHST- 2022/05/10 06:00 [pubmed]
PHST- 2022/08/17 06:00 [medline]
PHST- 2022/05/09 18:14 [entrez]
AID - S0271-5317(22)00028-8 [pii]
AID - 10.1016/j.nutres.2022.03.012 [doi]
PST - ppublish
SO  - Nutr Res. 2022 Aug;104:10-19. doi: 10.1016/j.nutres.2022.03.012. Epub 2022 Mar 
      27.