PMID- 35533678
OWN - NLM
STAT- Publisher
LR  - 20240216
IS  - 1942-7522 (Electronic)
IS  - 0145-5613 (Linking)
DP  - 2022 May 9
TI  - Predictors of Thyroid Gland Invasion in Total Laryngectomy for Advanced Laryngeal 
      Squamous Cell Carcinoma.
PG  - 1455613221098300
LID - 10.1177/01455613221098300 [doi]
AB  - Objectives: Thyroidectomy for advanced laryngeal squamous cell carcinoma (LSCC) 
      is controversial. This study aimed to identify predictors of thyroid gland 
      invasion in patients with LSCC and management of the thyroid gland during total 
      laryngectomy. Patients and Methods: Clinical data and pathological 
      characteristics of 113 patients, who underwent laryngectomy with thyroidectomy 
      for advanced LSCC in Guangdong Provincial People's Hospital between 2009 and 
      2019, were retrospectively analyzed. The incidence and predictors of thyroid 
      gland invasion were analyzed, and a new predictor was proposed using a parallel 
      test. Results: Of 113 patients, 25.7% exhibited thyroid invasion. A new predictor 
      that combined the lower third of thyroid cartilage invasion and thyroid gland 
      invasion on computed tomography/magnetic resonance imaging (CT/MRI) was 
      associated with pathological thyroid gland invasion (P = 0.001; sensitivity, 
      88.2%; negative predictive value, 95%). Conclusion: Thyroidectomy may be required 
      during total laryngectomy in those with invasion of the lower third of thyroid 
      cartilage and/or thyroid gland invasion revealed on CT/MRI instead of being 
      performed routinely.
FAU - Xie, Jiaxuan
AU  - Xie J
AD  - Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - 66477Shantou University Medical College, Shantou, China.
FAU - Liu, Hui
AU  - Liu H
AD  - Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - 66477Shantou University Medical College, Shantou, China.
FAU - Wu, Peiyan
AU  - Wu P
AD  - Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
AD  - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, 
      China.
FAU - Chen, Liangsi
AU  - Chen L
AD  - Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
FAU - Ge, Pingjiang
AU  - Ge P
AD  - Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
FAU - Chen, Shaohua
AU  - Chen S
AD  - Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
FAU - Zhang, Siyi
AU  - Zhang S
AD  - Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
FAU - Lu, Zhongming
AU  - Lu Z
AUID- ORCID: 0000-0003-1976-5671
AD  - Department of Otolaryngology-Head and Neck Surgery, 89346Guangdong Provincial 
      People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
LA  - eng
PT  - Journal Article
DEP - 20220509
PL  - United States
TA  - Ear Nose Throat J
JT  - Ear, nose, & throat journal
JID - 7701817
SB  - IM
OTO - NOTNLM
OT  - laryngeal squamous cell carcinoma
OT  - predictors
OT  - thyroid cartilage
OT  - thyroid gland invasion
OT  - total laryngectomy
EDAT- 2022/05/10 06:00
MHDA- 2022/05/10 06:00
CRDT- 2022/05/09 18:34
PHST- 2022/05/10 06:00 [pubmed]
PHST- 2022/05/10 06:00 [medline]
PHST- 2022/05/09 18:34 [entrez]
AID - 10.1177/01455613221098300 [doi]
PST - aheadofprint
SO  - Ear Nose Throat J. 2022 May 9:1455613221098300. doi: 10.1177/01455613221098300.