PMID- 35534046
OWN - NLM
STAT- MEDLINE
DCOM- 20220511
LR  - 20220722
IS  - 2054-4774 (Print)
IS  - 2054-4774 (Electronic)
IS  - 2054-4774 (Linking)
VI  - 9
IP  - 1
DP  - 2022 May
TI  - Heyde's syndrome: a systematic review of case reports.
LID - 10.1136/bmjgast-2021-000866 [doi]
LID - e000866
AB  - OBJECTIVE: Heyde's syndrome (HS), a rare condition characterised by a unique 
      relationship between severe aortic stenosis and angiodysplasia, is often 
      diagnosed late increasing the risk for a prolonged hospital course and mortality 
      in the elderly. The leading hypothesis explaining the aetiology of HS is acquired 
      von Willebrand syndrome (AVWS) but not all studies support this claim. While 
      individual cases of HS have been reported, here we present the first systematic 
      review of case reports and focus on the prevalence of AVWS. DESIGN: A systematic 
      search was conducted through PubMed/MEDLINE, CINAHL-EBSCO, Web of Science and 
      Google Scholar since inception. The resulting articles were screened by two 
      independent reviewers based on inclusion criteria that the article must be a case 
      report/series or a letter to the editor in English describing HS in an adult 
      patient. RESULTS: Seventy-four articles encompassing 77 cases met the inclusion 
      criteria. The average age was 74.3+/-9.3 years old with a slight female 
      predominance. The small intestine, especially the jejunum, was the most common 
      location for bleeding origin. Capsule endoscopy and double balloon enteroscopy 
      were superior at identifying bleeding sources than colonoscopy (p=0.0027 and 
      p=0.0095, respectively) and oesophagogastroduodenoscopy (p=0.0006 and p=0.0036, 
      respectively). The mean duration from symptom onset to diagnosis/treatment of HS 
      was 23.8+/-39 months. Only 27/77 cases provided evidence for AVWS. Surgical and 
      transcutaneous aortic valve replacement (AVR) were superior at preventing 
      rebleeding than non-AVR modalities (p<0.0001). CONCLUSION: Further research is 
      warranted for a stronger understanding and increased awareness of HS, which may 
      hasten diagnosis and optimal management.
CI  - (c) Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No 
      commercial re-use. See rights and permissions. Published by BMJ.
FAU - Saha, Bibek
AU  - Saha B
AUID- ORCID: 0000-0002-1976-126X
AD  - John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, 
      Hawaii, USA bsaha2@hawaii.edu.
FAU - Wien, Eric
AU  - Wien E
AD  - John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, 
      Hawaii, USA.
AD  - Internal Medicine Residency Program, University of Hawai'i at Manoa, Honolulu, 
      Hawaii, USA.
FAU - Fancher, Nicholas
AU  - Fancher N
AD  - John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, 
      Hawaii, USA.
FAU - Kahili-Heede, Melissa
AU  - Kahili-Heede M
AD  - John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, 
      Hawaii, USA.
FAU - Enriquez, Nathaniel
AU  - Enriquez N
AD  - John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, 
      Hawaii, USA.
AD  - Internal Medicine Residency Program, University of Hawai'i at Manoa, Honolulu, 
      Hawaii, USA.
FAU - Velasco-Hughes, Alena
AU  - Velasco-Hughes A
AD  - John A. Burns School of Medicine, University of Hawai'i at Manoa, Honolulu, 
      Hawaii, USA.
AD  - Queen's Medical Group Hospitalist Program, Queen's Medical Center, Honolulu, 
      Hawaii, USA.
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Systematic Review
PL  - England
TA  - BMJ Open Gastroenterol
JT  - BMJ open gastroenterology
JID - 101660690
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - *Angiodysplasia/complications/diagnosis
MH  - Aortic Valve
MH  - *Aortic Valve Stenosis/complications/diagnosis/surgery
MH  - *Capsule Endoscopy/adverse effects
MH  - Female
MH  - Gastrointestinal Hemorrhage/diagnosis/etiology
MH  - Humans
MH  - Male
MH  - Syndrome
MH  - *von Willebrand Diseases/complications/diagnosis/epidemiology
PMC - PMC9086603
OTO - NOTNLM
OT  - angiodysplasia
OT  - diagnostic and therapeutic endoscopy
OT  - gastrointestinal bleeding
OT  - small bowel enteroscopy
COIS- Competing interests: None declared.
EDAT- 2022/05/10 06:00
MHDA- 2022/05/12 06:00
PMCR- 2022/05/09
CRDT- 2022/05/09 20:43
PHST- 2021/12/20 00:00 [received]
PHST- 2022/03/27 00:00 [accepted]
PHST- 2022/05/09 20:43 [entrez]
PHST- 2022/05/10 06:00 [pubmed]
PHST- 2022/05/12 06:00 [medline]
PHST- 2022/05/09 00:00 [pmc-release]
AID - bmjgast-2021-000866 [pii]
AID - 10.1136/bmjgast-2021-000866 [doi]
PST - ppublish
SO  - BMJ Open Gastroenterol. 2022 May;9(1):e000866. doi: 10.1136/bmjgast-2021-000866.