PMID- 35535905
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1673-5374 (Print)
IS  - 1876-7958 (Electronic)
IS  - 1673-5374 (Linking)
VI  - 17
IP  - 11
DP  - 2022 Nov
TI  - Human umbilical cord-derived mesenchymal stem cells promote repair of neonatal 
      brain injury caused by hypoxia/ischemia in rats.
PG  - 2518-2525
LID - 10.4103/1673-5374.339002 [doi]
AB  - Administration of human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) 
      is believed to be an effective method for treating neurodevelopmental disorders. 
      In this study, we investigated the possibility of hUC-MSCs treatment of neonatal 
      hypoxic/ischemic brain injury associated with maternal immune activation and the 
      underlying mechanism. We established neonatal rat models of hypoxic/ischemic 
      brain injury by exposing pregnant rats to lipopolysaccharide on day 16 or 17 of 
      pregnancy. Rat offspring were intranasally administered hUC-MSCs on postnatal day 
      14. We found that polypyrimidine tract-binding protein-1 (PTBP-1) participated in 
      the regulation of lipopolysaccharide-induced maternal immune activation, which 
      led to neonatal hypoxic/ischemic brain injury. Intranasal delivery of hUC-MSCs 
      inhibited PTBP-1 expression, alleviated neonatal brain injury-related 
      inflammation, and regulated the number and function of glial fibrillary acidic 
      protein-positive astrocytes, thereby promoting plastic regeneration of neurons 
      and improving brain function. These findings suggest that hUC-MSCs can 
      effectively promote the repair of neonatal hypoxic/ischemic brain injury related 
      to maternal immune activation through inhibition of PTBP-1 expression and 
      astrocyte activation.
FAU - Jiao, Yang
AU  - Jiao Y
AD  - Stem Cell Clinical Research Center, National Joint Engineering Laboratory, 
      Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical 
      University; Dalian Innovation Institute of Stem Cells and Precision Medicine; 
      Department of Neurology, The First Affiliated Hospital of Dalian Medical 
      University, Dalian, Liaoning Province, China.
FAU - Sun, Yue-Tong
AU  - Sun YT
AD  - College of Life Science, Liaoning Normal University, Dalian, Liaoning Province, 
      China.
FAU - Chen, Nai-Fei
AU  - Chen NF
AD  - College of Life Science, Liaoning Normal University, Dalian, Liaoning Province, 
      China.
FAU - Zhou, Li-Na
AU  - Zhou LN
AD  - Stem Cell Clinical Research Center, National Joint Engineering Laboratory, 
      Regenerative Medicine Center; Department of Neurology, The First Affiliated 
      Hospital of Dalian Medical University, Dalian, Liaoning Province, China.
FAU - Guan, Xin
AU  - Guan X
AD  - Stem Cell Clinical Research Center, National Joint Engineering Laboratory, 
      Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical 
      University; Dalian Innovation Institute of Stem Cells and Precision Medicine, 
      Dalian, Liaoning Province, China.
FAU - Wang, Jia-Yi
AU  - Wang JY
AD  - Stem Cell Clinical Research Center, National Joint Engineering Laboratory, 
      Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical 
      University; Dalian Innovation Institute of Stem Cells and Precision Medicine, 
      Dalian, Liaoning Province, China.
FAU - Wei, Wen-Juan
AU  - Wei WJ
AD  - Stem Cell Clinical Research Center, National Joint Engineering Laboratory, 
      Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical 
      University; Dalian Innovation Institute of Stem Cells and Precision Medicine, 
      Dalian, Liaoning Province, China.
FAU - Han, Chao
AU  - Han C
AD  - Stem Cell Clinical Research Center, National Joint Engineering Laboratory, 
      Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical 
      University; Dalian Innovation Institute of Stem Cells and Precision Medicine, 
      Dalian, Liaoning Province, China.
FAU - Jiang, Xiao-Lei
AU  - Jiang XL
AD  - College of Life Science, Liaoning Normal University, Dalian, Liaoning Province, 
      China.
FAU - Wang, Ya-Chen
AU  - Wang YC
AD  - Stem Cell Clinical Research Center, National Joint Engineering Laboratory, 
      Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical 
      University; Dalian Innovation Institute of Stem Cells and Precision Medicine, 
      Dalian, Liaoning Province, China.
FAU - Zou, Wei
AU  - Zou W
AD  - Dalian Innovation Institute of Stem Cells and Precision Medicine; College of Life 
      Science, Liaoning Normal University, Dalian, Liaoning Province, China.
FAU - Liu, Jing
AU  - Liu J
AD  - Stem Cell Clinical Research Center, National Joint Engineering Laboratory, 
      Regenerative Medicine Center, The First Affiliated Hospital of Dalian Medical 
      University; Dalian Innovation Institute of Stem Cells and Precision Medicine, 
      Dalian, Liaoning Province, China.
LA  - eng
PT  - Journal Article
PL  - India
TA  - Neural Regen Res
JT  - Neural regeneration research
JID - 101316351
PMC - PMC9120712
OTO - NOTNLM
OT  - developmental brain disease model
OT  - disease-associated astrocytes
OT  - intranasal administration
OT  - lipopolysaccharide
OT  - maternal immune activation
OT  - neonatal brain injury
OT  - neuroplasticity repair
OT  - polypyrimidine tract-binding protein-1
OT  - stem cell therapy
OT  - umbilical cord-derived mesenchymal stem cells
COIS- None
EDAT- 2022/05/11 06:00
MHDA- 2022/05/11 06:01
PMCR- 2022/04/01
CRDT- 2022/05/10 07:58
PHST- 2022/05/10 07:58 [entrez]
PHST- 2022/05/11 06:00 [pubmed]
PHST- 2022/05/11 06:01 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - NeuralRegenRes_2022_17_11_2518_339002 [pii]
AID - NRR-17-2518 [pii]
AID - 10.4103/1673-5374.339002 [doi]
PST - ppublish
SO  - Neural Regen Res. 2022 Nov;17(11):2518-2525. doi: 10.4103/1673-5374.339002.