PMID- 35535976
OWN - NLM
STAT- MEDLINE
DCOM- 20220719
LR  - 20220909
IS  - 1532-2149 (Electronic)
IS  - 1090-3801 (Linking)
VI  - 26
IP  - 7
DP  - 2022 Aug
TI  - Temporal properties of pain contrast enhancement using repetitive stimulation.
PG  - 1437-1447
LID - 10.1002/ejp.1971 [doi]
AB  - BACKGROUND: Offset analgesia (OA) is characterized by a disproportionately large 
      reduction in pain following a small decrease in noxious stimulation and is based 
      on temporal pain contrast enhancement (TPCE). The underlying mechanisms of this 
      phenomenon are still poorly understood. This study is aiming to investigate 
      whether TPCE can also be induced by repetitive stimulation, i.e., by stimuli 
      clearly separated in time. METHODS: A repetitive TPCE paradigm was induced in 
      healthy, pain-free subjects (n = 33) using heat stimuli. Three different 
      interstimulus intervals (ISIs) were used: 5, 15, and 25 s. All paradigms were 
      contrasted with a control paradigm without temperature change. Participants 
      continuously rated perceived pain intensity. In addition, electrodermal activity 
      (EDA) was recorded as a surrogate measure of autonomic arousal. RESULTS: Temporal 
      pain contrast enhancement was confirmed for ISI 5 s (p < 0.001) and ISI 15 s 
      (p = 0.005) but not for ISI 25 s (p = 0.07), however, the magnitude of TPCE did 
      not differ between ISIs (p = 0.11). A TPCE-like effect was also detected with 
      increased EDA values. CONCLUSIONS: TPCE can be induced by repetitive stimulation. 
      This finding may be explained by a combination of the mechanisms underlying the 
      OA and a facilitated pain habituation. SIGNIFICANCE: This experiment shows for 
      the first time that temporal contrast enhancement of pain can be elicited by 
      stimuli that are clearly separated in time with an interstimulus interval below 
      25 s.
CI  - (c) 2022 The Authors. European Journal of Pain published by John Wiley & Sons Ltd 
      on behalf of European Pain Federation - EFIC(R).
FAU - Szikszay, Tibor M
AU  - Szikszay TM
AUID- ORCID: 0000-0002-6351-2957
AD  - Department of Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L.), 
      Institute of Health Sciences, Universitat zu Lubeck, Luebeck, Germany.
FAU - Adamczyk, Waclaw M
AU  - Adamczyk WM
AUID- ORCID: 0000-0001-8941-8355
AD  - Department of Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L.), 
      Institute of Health Sciences, Universitat zu Lubeck, Luebeck, Germany.
AD  - Laboratory of Pain Research, Institute of Physiotherapy and Health Sciences, The 
      Jerzy Kukuczka Academy of Physical Education, Katowice, Poland.
FAU - Levenez, Juliette L M
AU  - Levenez JLM
AD  - Department of Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L.), 
      Institute of Health Sciences, Universitat zu Lubeck, Luebeck, Germany.
FAU - Gouverneur, Philip
AU  - Gouverneur P
AUID- ORCID: 0000-0001-8610-2291
AD  - Institute of Medical Informatics, University of Luebeck, Luebeck, Germany.
FAU - Luedtke, Kerstin
AU  - Luedtke K
AUID- ORCID: 0000-0002-7308-5469
AD  - Department of Physiotherapy, Pain and Exercise Research Luebeck (P.E.R.L.), 
      Institute of Health Sciences, Universitat zu Lubeck, Luebeck, Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220517
PL  - England
TA  - Eur J Pain
JT  - European journal of pain (London, England)
JID - 9801774
SB  - IM
MH  - *Analgesia
MH  - Hot Temperature
MH  - Humans
MH  - *Pain
MH  - Pain Management
MH  - Pain Measurement
EDAT- 2022/05/11 06:00
MHDA- 2022/07/20 06:00
CRDT- 2022/05/10 08:33
PHST- 2022/03/21 00:00 [revised]
PHST- 2022/01/06 00:00 [received]
PHST- 2022/05/07 00:00 [accepted]
PHST- 2022/05/11 06:00 [pubmed]
PHST- 2022/07/20 06:00 [medline]
PHST- 2022/05/10 08:33 [entrez]
AID - 10.1002/ejp.1971 [doi]
PST - ppublish
SO  - Eur J Pain. 2022 Aug;26(7):1437-1447. doi: 10.1002/ejp.1971. Epub 2022 May 17.