PMID- 35538538
OWN - NLM
STAT- MEDLINE
DCOM- 20220512
LR  - 20220716
IS  - 1477-7819 (Electronic)
IS  - 1477-7819 (Linking)
VI  - 20
IP  - 1
DP  - 2022 May 10
TI  - Multiple endocrine neoplasia type 1 involving both the liver and lung: a case 
      report.
PG  - 151
LID - 10.1186/s12957-022-02622-1 [doi]
LID - 151
AB  - BACKGROUND: Multiple endocrine neoplasia type 1 (MEN1) is a rare autosomal 
      dominant tumor syndrome with a high degree of heterogeneity in clinical 
      phenotypes, generally involving the parathyroid, anterior pituitary, and 
      enteropancreas. In recent years, several new insights into the clinical features 
      of MEN1 have been reported in the literature. However, it is not clear whether 
      MEN1-associated primary tumors can occur in the liver. CASE PRESENTATION: We 
      report the case of a 52-year-old man with multiple endocrine neoplasia type 1 
      diagnosed by genetic sequencing. After uniportal thoracoscopic right middle 
      lobectomy, laparoscopic radical resection of the liver tumors, and radiofrequency 
      ablation of the parathyroid space, the parathyroid hormone level decreased from 
      177 pg/ml to a normal level (20 pg/ml). No local tumor recurrence was observed 
      during a follow-up of 5 months. CONCLUSION: We report the first case of MEN1 with 
      simultaneous liver and lung involvement in which the patient underwent radical 
      resection of the tumors, and we propose the possibility that the liver and other 
      nonendocrine organs may also develop diseases associated with MEN1; although, 
      this view needs further verification. Gene detection has crucial clinical 
      significance for guiding diagnosis and treatment.
CI  - (c) 2022. The Author(s).
FAU - Lai, Jianlin
AU  - Lai J
AD  - Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
AD  - Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Fujian Medical 
      University, Fuzhou, China.
FAU - Huang, Yangyang
AU  - Huang Y
AD  - Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
AD  - Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Fujian Medical 
      University, Fuzhou, China.
FAU - Wu, Junyi
AU  - Wu J
AD  - Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China.
AD  - Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Fujian Medical 
      University, Fuzhou, China.
FAU - Cheng, Hui
AU  - Cheng H
AD  - Department of Pathology, Fujian Provincial Hospital, Fujian Medical University, 
      Fuzhou, China.
FAU - Qiu, Funan
AU  - Qiu F
AUID- ORCID: 0000-0003-4122-728X
AD  - Shengli Clinical Medical College of Fujian Medical University, Fuzhou, China. 
      qiufunan72@163.com.
AD  - Department of Hepatobiliary Surgery, Fujian Provincial Hospital, Fujian Medical 
      University, Fuzhou, China. qiufunan72@163.com.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220510
PL  - England
TA  - World J Surg Oncol
JT  - World journal of surgical oncology
JID - 101170544
SB  - IM
MH  - Abdomen
MH  - Humans
MH  - Liver
MH  - Lung
MH  - *Multiple Endocrine Neoplasia Type 1/complications/genetics/surgery
MH  - Neoplasm Recurrence, Local/complications
PMC - PMC9088025
OTO - NOTNLM
OT  - Case report
OT  - Genetic sequencing
OT  - Liver
OT  - Lung
OT  - Multiple endocrine neoplasia type 1
COIS- The authors declare that they have no competing interests.
EDAT- 2022/05/11 06:00
MHDA- 2022/05/14 06:00
PMCR- 2022/05/10
CRDT- 2022/05/10 23:41
PHST- 2021/10/04 00:00 [received]
PHST- 2022/05/01 00:00 [accepted]
PHST- 2022/05/10 23:41 [entrez]
PHST- 2022/05/11 06:00 [pubmed]
PHST- 2022/05/14 06:00 [medline]
PHST- 2022/05/10 00:00 [pmc-release]
AID - 10.1186/s12957-022-02622-1 [pii]
AID - 2622 [pii]
AID - 10.1186/s12957-022-02622-1 [doi]
PST - epublish
SO  - World J Surg Oncol. 2022 May 10;20(1):151. doi: 10.1186/s12957-022-02622-1.