PMID- 35539048
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 9
IP  - 63
DP  - 2019 Nov 11
TI  - A novel drug-drug nanohybrid for the self-delivery of porphyrin and cis-platinum.
PG  - 37003-37008
LID - 10.1039/c9ra07085k [doi]
AB  - The thriving development of nanotechnology has greatly promoted the development 
      of drug delivery systems (DDSs) in the past decades. However, most DDSs 
      themselves cannot serve as diagnostic reagents and must be metabolized, by which 
      they may become poisonous and even cause immune reactions. In this study, a novel 
      self-delivery drug-drug system (SDDS) nanohybrid based on the coordination 
      assembly of a photodynamic reagent, tetra-(4-carboxyphenyl)porphyrin (TCPP), and 
      a chemotherapy reagent, cis-platinum, was designed and synthesized. The four 
      carboxyl groups of TCPP can compete with the chloride ions of cis-platinum by 
      coordination interactions, forming a TCPP-cis-platinum nanohybrid (PCNH) for the 
      purpose of photodynamic/chemotherapeutic synergistic treatment with a 
      combinational index of 0.28. Meanwhile, the PCNH system can effectively protect 
      the photosensitizer TCPP from photobleaching when irradiated continuously in the 
      photodynamic therapy (PDT) process, which is very crucial for PDT. Furthermore, 
      introduction of the heavy atom platinum can greatly enhance the producing 
      efficiency of (1)O(2) by 46%. In addition, the red emission fluorescence of TCPP 
      is beneficial for monitoring and tracing the process of drug delivery when used 
      in vitro. This work may pave a new way for the design of new integrated 
      nanohybrids for diagnosis and synergistic treatment.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Shan, Changfu
AU  - Shan C
AD  - State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous 
      Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry 
      and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China 
      tangyu@lzu.edu.cn caoj@lzu.edu.cn.
FAU - Ru, Jiaxi
AU  - Ru J
AUID- ORCID: 0000-0002-7469-1911
AD  - State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary 
      Research Institute, Chinese Academy of Agricultural Sciences Lanzhou 730046 P. R. 
      China guohuichen@caas.cn.
FAU - Zhang, Meina
AU  - Zhang M
AD  - State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous 
      Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry 
      and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China 
      tangyu@lzu.edu.cn caoj@lzu.edu.cn.
FAU - Cao, Jing
AU  - Cao J
AUID- ORCID: 0000-0003-3978-911X
AD  - State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous 
      Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry 
      and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China 
      tangyu@lzu.edu.cn caoj@lzu.edu.cn.
FAU - Liu, Weisheng
AU  - Liu W
AUID- ORCID: 0000-0001-5448-6315
AD  - State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous 
      Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry 
      and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China 
      tangyu@lzu.edu.cn caoj@lzu.edu.cn.
FAU - Guo, Huichen
AU  - Guo H
AD  - State Key Laboratory of Veterinary Etiological Biology, Lanzhou Veterinary 
      Research Institute, Chinese Academy of Agricultural Sciences Lanzhou 730046 P. R. 
      China guohuichen@caas.cn.
FAU - Tang, Yu
AU  - Tang Y
AUID- ORCID: 0000-0003-3933-043X
AD  - State Key Laboratory of Applied Organic Chemistry, Key Laboratory of Nonferrous 
      Metal Chemistry and Resources Utilization of Gansu Province, College of Chemistry 
      and Chemical Engineering, Lanzhou University Lanzhou 730000 P. R. China 
      tangyu@lzu.edu.cn caoj@lzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20191112
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9075146
COIS- There are no conflicts to declare.
EDAT- 2019/11/12 00:00
MHDA- 2019/11/12 00:01
PMCR- 2019/11/12
CRDT- 2022/05/11 03:46
PHST- 2019/09/04 00:00 [received]
PHST- 2019/10/23 00:00 [accepted]
PHST- 2022/05/11 03:46 [entrez]
PHST- 2019/11/12 00:00 [pubmed]
PHST- 2019/11/12 00:01 [medline]
PHST- 2019/11/12 00:00 [pmc-release]
AID - c9ra07085k [pii]
AID - 10.1039/c9ra07085k [doi]
PST - epublish
SO  - RSC Adv. 2019 Nov 12;9(63):37003-37008. doi: 10.1039/c9ra07085k. eCollection 2019 
      Nov 11.