PMID- 35539076
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20240229
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 9
IP  - 63
DP  - 2019 Nov 11
TI  - Recent advances in metallopolymer-based drug delivery systems.
PG  - 37009-37051
LID - 10.1039/c9ra06678k [doi]
AB  - Metallopolymers (MPs) or metal-containing polymers have shown great potential as 
      new drug delivery systems (DDSs) due to their unique properties, including 
      universal architectures, composition, properties and surface chemistry. Over the 
      past few decades, the exponential growth of many new classes of MPs that deal 
      with these issues has been demonstrated. This review presents and assesses the 
      recent advances and challenges associated with using MPs as DDSs. Among the most 
      widely used MPs for these purposes, metal complexes based on synthetic and 
      natural polymers, coordination polymers, metal-organic frameworks, and 
      metallodendrimers are distinguished. Particular attention is paid to the 
      stimulus- and multistimuli-responsive metallopolymer-based DDSs. Of considerable 
      interest is the use of MPs for combination therapy and multimodal systems. 
      Finally, the problems and future prospects of using metallopolymer-based DDSs are 
      outlined. The bibliography includes articles published over the past five years.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Dzhardimalieva, Gulzhian I
AU  - Dzhardimalieva GI
AD  - Laboratory of Metallopolymers, The Institute of Problems of Chemical Physics RAS 
      Academician Semenov Avenue 1 Chernogolovka Moscow Region 142432 Russian 
      Federation dzhardim@icp.ac.ru.
AD  - Moscow Aviation Institute (National Research University) Volokolamskoe Shosse, 4 
      Moscow 125993 Russia f9_dec@mai.ru kamila.kydralieva@gmail.com.
FAU - Rabinskiy, Lev N
AU  - Rabinskiy LN
AD  - Moscow Aviation Institute (National Research University) Volokolamskoe Shosse, 4 
      Moscow 125993 Russia f9_dec@mai.ru kamila.kydralieva@gmail.com.
FAU - Kydralieva, Kamila A
AU  - Kydralieva KA
AD  - Moscow Aviation Institute (National Research University) Volokolamskoe Shosse, 4 
      Moscow 125993 Russia f9_dec@mai.ru kamila.kydralieva@gmail.com.
FAU - Uflyand, Igor E
AU  - Uflyand IE
AUID- ORCID: 0000-0002-7164-8168
AD  - Department of Chemistry, Southern Federal University B. Sadovaya Str. 105/42 
      Rostov-on-Don 344006 Russian Federation ieuflyand@sfedu.ru.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20191113
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9075603
COIS- No potential conflict of interest was reported by the authors.
EDAT- 2019/11/13 00:00
MHDA- 2019/11/13 00:01
PMCR- 2019/11/13
CRDT- 2022/05/11 03:46
PHST- 2019/08/24 00:00 [received]
PHST- 2019/11/06 00:00 [accepted]
PHST- 2022/05/11 03:46 [entrez]
PHST- 2019/11/13 00:00 [pubmed]
PHST- 2019/11/13 00:01 [medline]
PHST- 2019/11/13 00:00 [pmc-release]
AID - c9ra06678k [pii]
AID - 10.1039/c9ra06678k [doi]
PST - epublish
SO  - RSC Adv. 2019 Nov 13;9(63):37009-37051. doi: 10.1039/c9ra06678k. eCollection 2019 
      Nov 11.