PMID- 3554010
OWN - NLM
STAT- MEDLINE
DCOM- 19870528
LR  - 20190701
IS  - 0304-3940 (Print)
IS  - 0304-3940 (Linking)
VI  - 75
IP  - 1
DP  - 1987 Mar 20
TI  - N-methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb 
      muscles preparation of the newborn rat studied in vitro.
PG  - 43-8
AB  - Bath-applied N-methyl-D,L-aspartate (NMA) was found to elicit locomotor 
      electromyogram (EMG) activity in ankle flexor and extensor muscles in an in vitro 
      lumbar cord-hindlimb preparation of the newborn rat. The frequency and burst 
      duration of the NMA-induced rhythmic EMG activity varied in a dose-dependent 
      manner. The locomotor activity was also observed in a mid sagittally split lumbar 
      spinal preparation, in which the frequency was much lower. It is concluded that 
      spinal neurones with N-methyl-D-aspartate (NMDA) receptors are involved in 
      producing locomotor activity in the rat and that each spinal half can generate 
      hindlimb locomotion on the ipsilateral side.
FAU - Kudo, N
AU  - Kudo N
FAU - Yamada, T
AU  - Yamada T
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Neurosci Lett
JT  - Neuroscience letters
JID - 7600130
RN  - 30KYC7MIAI (Aspartic Acid)
RN  - 6384-92-5 (N-Methylaspartate)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Aspartic Acid/*analogs & derivatives/pharmacology
MH  - Hindlimb
MH  - In Vitro Techniques
MH  - Motor Activity/*drug effects
MH  - N-Methylaspartate
MH  - Neuromuscular Junction/drug effects/physiology
MH  - Neurons/drug effects/physiology
MH  - Rats
MH  - Rats, Inbred Strains
MH  - Spinal Cord/*drug effects/physiology
EDAT- 1987/03/20 00:00
MHDA- 1987/03/20 00:01
CRDT- 1987/03/20 00:00
PHST- 1987/03/20 00:00 [pubmed]
PHST- 1987/03/20 00:01 [medline]
PHST- 1987/03/20 00:00 [entrez]
AID - 0304-3940(87)90072-3 [pii]
AID - 10.1016/0304-3940(87)90072-3 [doi]
PST - ppublish
SO  - Neurosci Lett. 1987 Mar 20;75(1):43-8. doi: 10.1016/0304-3940(87)90072-3.