PMID- 35540837
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 8
IP  - 18
DP  - 2018 Mar 5
TI  - A pH and magnetic dual-response hydrogel for synergistic chemo-magnetic 
      hyperthermia tumor therapy.
PG  - 9812-9821
LID - 10.1039/c8ra00215k [doi]
AB  - To overcome the toxicity of chemotherapy, increasing attention has been paid to 
      local drug delivery systems (DDSs). pH-Sensitive hydrogels have emerged as 
      promising DDS materials in the biomedical field due to their remarkable 
      characteristics. However, the pH environment in tumor varies from person to 
      person, which makes the applicability of systems based on pH challenging. In this 
      study, we developed a contractible hydroxypropyl methyl cellulose 
      (HPMC)/Fe(3)O(4) hydrogel with dual-response pH and magnetic properties aiming to 
      overcome the limitations of pH-sensitive hydrogel drug delivery systems and 
      further increase their efficiency in tumor therapy. The HPMC/Fe(3)O(4) hydrogel 
      could act as a drug delivery system that combines pH-sensitive triggering and 
      magnetic dual-response drug release for synergistic chemo-magnetic hyperthermia 
      therapy. The drug delivery profile of the HPMC/Fe(3)O(4)/doxorubicin 
      hydrochloride (DOX) hydrogel was determined in vitro and revealed a remarkable 
      pH-sensitive performance. After synergistic chemo-magnetic hyperthermia 
      treatment, mice with 4T1 breast cancer xenografts recovered without any 
      recurrence or metastasis, demonstrating the synergistic effect of chemotherapy 
      and magnetic hyperthermia therapy. Meanwhile, reduced toxicity and superior 
      anticancer effects were achieved due to the combined effect of the pH and 
      magnetic hyperthermia response properties. This study demonstrated the high 
      efficacy and low toxicity of the improved design of HPMC/Fe(3)O(4) for drug 
      delivery, which may provide a promising approach for the application of 
      chemo-magnetic hyperthermia cancer therapy.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Zhou, Xiaohan
AU  - Zhou X
AD  - Chongqing Key Laboratory of Ultrasound Molecular Imaging, State Key Laboratory of 
      Ultrasound Engineering in Medicine Co-Founded by Chongqing, The Ministry of 
      Science and Technology, Second Affiliated Hospital of Chongqing Medical 
      University Chongqing 400010 PR China zhengyuanyi@163.com.
FAU - Wang, Longchen
AU  - Wang L
AD  - Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 
      PR China.
FAU - Xu, Yanjun
AU  - Xu Y
AD  - Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 
      PR China.
FAU - Du, Wenxian
AU  - Du W
AD  - State Key Laboratory of High Performance Ceramic and Superfine Microstructures, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences Shanghai 200050 PR 
      China.
FAU - Cai, Xiaojun
AU  - Cai X
AD  - Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 
      PR China.
FAU - Wang, Fengjuan
AU  - Wang F
AD  - Chongqing Key Laboratory of Ultrasound Molecular Imaging, State Key Laboratory of 
      Ultrasound Engineering in Medicine Co-Founded by Chongqing, The Ministry of 
      Science and Technology, Second Affiliated Hospital of Chongqing Medical 
      University Chongqing 400010 PR China zhengyuanyi@163.com.
FAU - Ling, Yi
AU  - Ling Y
AD  - Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 
      PR China.
FAU - Chen, Hangrong
AU  - Chen H
AUID- ORCID: 0000-0003-0827-1270
AD  - State Key Laboratory of High Performance Ceramic and Superfine Microstructures, 
      Shanghai Institute of Ceramics, Chinese Academy of Sciences Shanghai 200050 PR 
      China.
FAU - Wang, Zhigang
AU  - Wang Z
AD  - Chongqing Key Laboratory of Ultrasound Molecular Imaging, State Key Laboratory of 
      Ultrasound Engineering in Medicine Co-Founded by Chongqing, The Ministry of 
      Science and Technology, Second Affiliated Hospital of Chongqing Medical 
      University Chongqing 400010 PR China zhengyuanyi@163.com.
FAU - Hu, Bing
AU  - Hu B
AD  - Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 
      PR China.
FAU - Zheng, Yuanyi
AU  - Zheng Y
AUID- ORCID: 0000-0002-1328-0641
AD  - Chongqing Key Laboratory of Ultrasound Molecular Imaging, State Key Laboratory of 
      Ultrasound Engineering in Medicine Co-Founded by Chongqing, The Ministry of 
      Science and Technology, Second Affiliated Hospital of Chongqing Medical 
      University Chongqing 400010 PR China zhengyuanyi@163.com.
AD  - Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai 200233 
      PR China.
LA  - eng
PT  - Journal Article
DEP - 20180308
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9078710
COIS- There are no conflicts to declare.
EDAT- 2018/03/08 00:00
MHDA- 2018/03/08 00:01
PMCR- 2018/03/08
CRDT- 2022/05/11 03:58
PHST- 2018/01/08 00:00 [received]
PHST- 2018/03/02 00:00 [accepted]
PHST- 2022/05/11 03:58 [entrez]
PHST- 2018/03/08 00:00 [pubmed]
PHST- 2018/03/08 00:01 [medline]
PHST- 2018/03/08 00:00 [pmc-release]
AID - c8ra00215k [pii]
AID - 10.1039/c8ra00215k [doi]
PST - epublish
SO  - RSC Adv. 2018 Mar 8;8(18):9812-9821. doi: 10.1039/c8ra00215k. eCollection 2018 
      Mar 5.