PMID- 35542233
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 8
IP  - 29
DP  - 2018 Apr 27
TI  - Cationic nanomicelles derived from Pluronic F127 as delivery vehicles of Chinese 
      herbal medicine active components of ursolic acid for colorectal cancer 
      treatment.
PG  - 15906-15914
LID - 10.1039/c8ra01071d [doi]
AB  - Ursolic acid (UA) has shown great potential in cancer therapy but their efficacy 
      is seriously compromised by poor water-solubility and limited cellular uptake. In 
      this paper, cationic nanomicelles self-assembled from Pluronic F127 with the 
      cationic polymer of C(18)-polyethylenimine (C(18)-PEI) as a functional component 
      are fabricated as delivery vehicles of Chinese herbal medicine active components 
      of ursolic acid (UA) for colorectal cancer treatment. The inhibition effects of 
      this drug loaded cationic nanomicelles (named as FUP) on cell viability and cell 
      colony formation were more significant than the free UA, due to their cationic 
      surface which can increase UA uptake by colorectal cancer cells. Cell cycle 
      analysis showed that this inhibition effect was mediated by a cell cycle arrest 
      at the G1 checkpoint, and the cell death induced by these nanomicelles occurred 
      via apoptosis, which was detected by annexin V antibody and propidium iodide 
      staining. Further western blot analysis demonstrated the apoptosis mechanism was 
      associated with the regulation of Fas/FasL and activation of caspase-8 and 
      caspase-3. Therefore, our cationic nanomicelles can potentially be used to 
      enhance the therapeutic effect of UA for colorectal cancer treatment.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Yan, Zhaokun
AU  - Yan Z
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine Fuzhou 350122 P. R. China jiumaolin@hotmail.com.
FAU - Wang, Qingtang
AU  - Wang Q
AD  - The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of 
      Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University 
      Fuzhou 350025 P. R. China wmmj0419@163.com.
AD  - The Liver Center of Fujian Province, Fujian Medical University Fuzhou 350025 P. 
      R. China.
FAU - Liu, Xiaolong
AU  - Liu X
AUID- ORCID: 0000-0002-3096-4981
AD  - The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of 
      Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University 
      Fuzhou 350025 P. R. China wmmj0419@163.com.
AD  - The Liver Center of Fujian Province, Fujian Medical University Fuzhou 350025 P. 
      R. China.
FAU - Peng, Jun
AU  - Peng J
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine Fuzhou 350122 P. R. China jiumaolin@hotmail.com.
AD  - Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of 
      Traditional Chinese Medicine Fuzhou Fujian 350122 P. R. China.
FAU - Li, Qin
AU  - Li Q
AD  - The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of 
      Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University 
      Fuzhou 350025 P. R. China wmmj0419@163.com.
AD  - The Liver Center of Fujian Province, Fujian Medical University Fuzhou 350025 P. 
      R. China.
FAU - Wu, Ming
AU  - Wu M
AUID- ORCID: 0000-0001-8326-4076
AD  - The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of 
      Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University 
      Fuzhou 350025 P. R. China wmmj0419@163.com.
AD  - The Liver Center of Fujian Province, Fujian Medical University Fuzhou 350025 P. 
      R. China.
FAU - Lin, Jiumao
AU  - Lin J
AD  - Academy of Integrative Medicine, Fujian University of Traditional Chinese 
      Medicine Fuzhou 350122 P. R. China jiumaolin@hotmail.com.
AD  - Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of 
      Traditional Chinese Medicine Fuzhou Fujian 350122 P. R. China.
LA  - eng
PT  - Journal Article
DEP - 20180427
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
PMC - PMC9080071
COIS- There are no conflicts to declare.
EDAT- 2018/04/27 00:00
MHDA- 2018/04/27 00:01
PMCR- 2018/04/27
CRDT- 2022/05/11 04:07
PHST- 2018/02/03 00:00 [received]
PHST- 2018/04/17 00:00 [accepted]
PHST- 2022/05/11 04:07 [entrez]
PHST- 2018/04/27 00:00 [pubmed]
PHST- 2018/04/27 00:01 [medline]
PHST- 2018/04/27 00:00 [pmc-release]
AID - c8ra01071d [pii]
AID - 10.1039/c8ra01071d [doi]
PST - epublish
SO  - RSC Adv. 2018 Apr 27;8(29):15906-15914. doi: 10.1039/c8ra01071d. eCollection 2018 
      Apr 27.