PMID- 35542655
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2046-2069 (Electronic)
IS  - 2046-2069 (Linking)
VI  - 9
IP  - 69
DP  - 2019 Dec 3
TI  - Retracted Article: Long noncoding RNA DLEU1 promotes cell proliferation and 
      migration of Wilms tumor through the miR-300/HOXC8 axis.
PG  - 40240-40247
LID - 10.1039/c9ra07215b [doi]
AB  - Wilms tumor (nephroblastoma) is the most common primary renal tumor occurring in 
      children. Long noncoding RNA (lncRNA) deleted in lymphocytic leukemia 1 (DLEU1) 
      is an identified cancer-associated lncRNA that plays an important role in various 
      cancers. However, the role of DLEU1 in Wilms tumor remains unclear. In the 
      present study, we examined the expression and role of DLEU1 in Wilms tumor. We 
      demonstrated that DLEU1 expression was upregulated in Wilms tumor tissues and 
      cell lines. Knockdown of DLEU1 significantly inhibited the proliferation, 
      migration and invasion of GHINK-1 cells. Furthermore, DLEU1 directly sponged 
      miR-300 and regulated the expression level of miR-300 in GHINK-1 cells. 
      Inhibition of miR-300 reversed the inhibitory effects of DLEU1 downregulation on 
      cell proliferation, migration and invasion. Homeobox C8 (HOXC8) was found to be a 
      target gene of miR-300 and mediated the role of miR-300 in GHINK-1 cells. In 
      conclusion, these findings indicated that DLEU1 executed an oncogenic role in 
      Wilms tumor via regulating the miR-300/HOXC8 axis, indicating that DLEU1 might be 
      a therapeutic target for the treatment of Wilms tumor.
CI  - This journal is (c) The Royal Society of Chemistry.
FAU - Ge, Wen'an
AU  - Ge W
AD  - Department of Urology, Xi'an Children's Hospital Xi'an 710003 China 
      shengxing_wang1@126.com +86-29-87692009 +86-29-87692210.
FAU - Wang, Shengxing
AU  - Wang S
AUID- ORCID: 0000-0003-0446-8914
AD  - Department of Urology, Xi'an Children's Hospital Xi'an 710003 China 
      shengxing_wang1@126.com +86-29-87692009 +86-29-87692210.
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
DEP - 20191204
PL  - England
TA  - RSC Adv
JT  - RSC advances
JID - 101581657
RIN - RSC Adv. 2021 Jan 27;11(9):5267. PMID: 35427068
PMC - PMC9076220
COIS- There are no conflicts to declare.
EDAT- 2019/12/04 00:00
MHDA- 2019/12/04 00:01
PMCR- 2019/12/04
CRDT- 2022/05/11 04:10
PHST- 2019/09/09 00:00 [received]
PHST- 2019/11/26 00:00 [accepted]
PHST- 2022/05/11 04:10 [entrez]
PHST- 2019/12/04 00:00 [pubmed]
PHST- 2019/12/04 00:01 [medline]
PHST- 2019/12/04 00:00 [pmc-release]
AID - c9ra07215b [pii]
AID - 10.1039/c9ra07215b [doi]
PST - epublish
SO  - RSC Adv. 2019 Dec 4;9(69):40240-40247. doi: 10.1039/c9ra07215b. eCollection 2019 
      Dec 3.