PMID- 35543923
OWN - NLM
STAT- MEDLINE
DCOM- 20220819
LR  - 20230301
IS  - 1880-4233 (Electronic)
IS  - 1340-6868 (Print)
IS  - 1340-6868 (Linking)
VI  - 29
IP  - 5
DP  - 2022 Sep
TI  - Relevance of the MHC region for breast cancer susceptibility in Asians.
PG  - 869-879
LID - 10.1007/s12282-022-01366-w [doi]
AB  - BACKGROUND: Human leukocyte antigen (HLA) genes play critical roles in immune 
      surveillance, an important defence against tumors. Imputing HLA genotypes from 
      existing single-nucleotide polymorphism datasets is low-cost and efficient. We 
      investigate the relevance of the major histocompatibility complex region in 
      breast cancer susceptibility, using imputed class I and II HLA alleles, in 25,484 
      women of Asian ancestry. METHODS: A total of 12,901 breast cancer cases and 
      12,583 controls from 12 case-control studies were included in our pooled 
      analysis. HLA imputation was performed using SNP2HLA on 10,886 quality-controlled 
      variants within the 15-55 Mb region on chromosome 6. HLA alleles (n = 175) with 
      info scores greater than 0.8 and frequencies greater than 0.01 were included 
      (resolution at two-digit level: 71; four-digit level: 104). We studied the 
      associations between HLA alleles and breast cancer risk using logistic 
      regression, adjusting for population structure and age. Associations between HLA 
      alleles and the risk of subtypes of breast cancer (ER-positive, ER-negative, 
      HER2-positive, HER2-negative, early-stage, and late-stage) were examined. 
      RESULTS: We did not observe associations between any HLA allele and breast cancer 
      risk at P < 5e-8; the smallest p value was observed for HLA-C*12:03 (OR = 1.29, 
      P = 1.08e-3). Ninety-five percent of the effect sizes (OR) observed were between 
      0.90 and 1.23. Similar results were observed when different subtypes of breast 
      cancer were studied (95% of ORs were between 0.85 and 1.18). CONCLUSIONS: No 
      imputed HLA allele was associated with breast cancer risk in our large Asian 
      study. Direct measurement of HLA gene expressions may be required to further 
      explore the associations between HLA genes and breast cancer risk.
CI  - (c) 2022. The Author(s).
FAU - Ho, Peh Joo
AU  - Ho PJ
AD  - Women's Health and Genetics, Genome Institute of Singapore, 60 Biopolis Street, 
      Genome, #02-01, Singapore, 138672, Singapore.
AD  - Saw Swee Hock School of Public Health, National University of Singapore and 
      National University Health System, Singapore, 119077, Singapore.
AD  - Department of Surgery, National University Health System, Singapore, 119228, 
      Singapore.
FAU - Khng, Alexis Jiaying
AU  - Khng AJ
AD  - Women's Health and Genetics, Genome Institute of Singapore, 60 Biopolis Street, 
      Genome, #02-01, Singapore, 138672, Singapore.
FAU - Tan, Benita Kiat-Tee
AU  - Tan BK
AD  - Department of Breast Surgery, Singapore General Hospital, Singapore, Singapore.
AD  - Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, 
      Singapore, Singapore.
AD  - Department of General Surgery, Sengkang General Hospital, Singapore, Singapore.
FAU - Tan, Ern Yu
AU  - Tan EY
AD  - Department of General Surgery, Tan Tock Seng Hospital, Singapore, 308433, 
      Singapore.
AD  - Lee Kong Chian School of Medicine, Singapore, Singapore.
AD  - Institute of Molecular and Cell Biology, Singapore, Singapore.
FAU - Tan, Su-Ming
AU  - Tan SM
AD  - Division of Breast Surgery, Changi General Hospital, Singapore, Singapore.
FAU - Tan, Veronique Kiak Mien
AU  - Tan VKM
AD  - Department of Breast Surgery, Singapore General Hospital, Singapore, Singapore.
AD  - Division of Surgery and Surgical Oncology, National Cancer Centre Singapore, 
      Singapore, Singapore.
FAU - Lim, Geok Hoon
AU  - Lim GH
AD  - KK Breast Department, KK Women's and Children's Hospital, Singapore, 229899, 
      Singapore.
FAU - Aronson, Kristan J
AU  - Aronson KJ
AD  - Department of Public Health Sciences, and Cancer Research Institute, Queen's 
      University, Kingston, ON, K7L 3N6, Canada.
FAU - Chan, Tsun L
AU  - Chan TL
AD  - Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong, Hong Kong.
AD  - Department of Molecular Pathology, Hong Kong Sanatorium and Hospital, Hong Kong, 
      Hong Kong.
FAU - Choi, Ji-Yeob
AU  - Choi JY
AD  - Department of Biomedical Sciences, Seoul National University Graduate School, 
      Seoul, 03080, Korea.
AD  - Cancer Research Institute, Seoul National University, Seoul, 03080, Korea.
AD  - Institute of Health Policy and Management, Seoul National University Medical 
      Research Center, Seoul, 03080, Korea.
FAU - Dennis, Joe
AU  - Dennis J
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic 
      Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
FAU - Ho, Weang-Kee
AU  - Ho WK
AD  - Department of Mathematical Sciences, Faculty of Science and Engineering, 
      University of Nottingham Malaysia Campus, 43500, Semenyih, Selangor, Malaysia.
AD  - Breast Cancer Research Programme, Cancer Research Malaysia, 47500, Subang Jaya, 
      Selangor, Malaysia.
FAU - Hou, Ming-Feng
AU  - Hou MF
AD  - Department of Surgery, Kaohsiung Municipal Hsiao-Kang Hospital, Kao-hsiung, 812, 
      Taiwan.
FAU - Ito, Hidemi
AU  - Ito H
AD  - Division of Cancer Information and Control, Aichi Cancer Center Research 
      Institute, Nagoya, 464-8681, Japan.
AD  - Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine, 
      Nagoya, 466-8550, Japan.
FAU - Iwasaki, Motoki
AU  - Iwasaki M
AD  - Division of Epidemiology, Center for Public Health Sciences, National Cancer 
      Center, Tokyo, 104-0045, Japan.
FAU - John, Esther M
AU  - John EM
AD  - Department of Epidemiology and Population Health, Stanford University School of 
      Medicine, Stanford, CA, 94305, USA.
AD  - Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford 
      University School of Medicine, Stanford, CA, 94304, USA.
FAU - Kang, Daehee
AU  - Kang D
AD  - Cancer Research Institute, Seoul National University, Seoul, 03080, Korea.
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, 03080, Korea.
FAU - Kim, Sung-Won
AU  - Kim SW
AD  - Department of Surgery, Daerim Saint Mary's Hospital, Seoul, 07442, Korea.
FAU - Kurian, Allison W
AU  - Kurian AW
AD  - Department of Epidemiology and Population Health, Stanford University School of 
      Medicine, Stanford, CA, 94305, USA.
AD  - Department of Medicine, Division of Oncology, Stanford Cancer Institute, Stanford 
      University School of Medicine, Stanford, CA, 94304, USA.
FAU - Kwong, Ava
AU  - Kwong A
AD  - Hong Kong Hereditary Breast Cancer Family Registry, Hong Kong, Hong Kong.
AD  - Department of Surgery, The University of Hong Kong, Hong Kong, Hong Kong.
AD  - Department of Surgery and Cancer Genetics Center, Hong Kong Sanatorium and 
      Hospital, Hong Kong, Hong Kong.
FAU - Lophatananon, Artitaya
AU  - Lophatananon A
AD  - Division of Population Health, Health Services Research and Primary Care, School 
      of Health Sciences, Faculty of Biology, Medicine and Health, The University of 
      Manchester, Manchester, M13 9PL, UK.
FAU - Matsuo, Keitaro
AU  - Matsuo K
AD  - Division of Cancer Epidemiology, Nagoya University Graduate School of Medicine, 
      Nagoya, 466-8550, Japan.
AD  - Division of Cancer Epidemiology and Prevention, Aichi Cancer Center Research 
      Institute, Nagoya, 464-8681, Japan.
FAU - Mohd-Taib, Nur Aishah
AU  - Mohd-Taib NA
AD  - Department of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala 
      Lumpur, Malaysia.
FAU - Muir, Kenneth
AU  - Muir K
AD  - Division of Population Health, Health Services Research and Primary Care, School 
      of Health Sciences, Faculty of Biology, Medicine and Health, The University of 
      Manchester, Manchester, M13 9PL, UK.
FAU - Murphy, Rachel A
AU  - Murphy RA
AD  - School of Population and Public Health, University of British Columbia, 
      Vancouver, BC, V6T 1Z4, Canada.
AD  - Cancer Control Research, BC Cancer, Vancouver, BC, V5Z 1L3, Canada.
FAU - Park, Sue K
AU  - Park SK
AD  - Cancer Research Institute, Seoul National University, Seoul, 03080, Korea.
AD  - Department of Preventive Medicine, Seoul National University College of Medicine, 
      Seoul, 03080, Korea.
AD  - Integrated Major in Innovative Medical Science, Seoul National University College 
      of Medicine, Seoul, 03080, South Korea.
FAU - Shen, Chen-Yang
AU  - Shen CY
AD  - Institute of Biomedical Sciences, Academia Sinica, Taipei, 115, Taiwan.
AD  - School of Public Health, China Medical University, Taichung, Taiwan.
FAU - Shu, Xiao-Ou
AU  - Shu XO
AD  - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, 
      Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 
      Nashville, TN, 37232, USA.
FAU - Teo, Soo Hwang
AU  - Teo SH
AD  - Breast Cancer Research Programme, Cancer Research Malaysia, 47500, Subang Jaya, 
      Selangor, Malaysia.
AD  - Department of Surgery, Faculty of Medicine, University of Malaya, 50603, Kuala 
      Lumpur, Malaysia.
FAU - Wang, Qin
AU  - Wang Q
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic 
      Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
FAU - Yamaji, Taiki
AU  - Yamaji T
AD  - Division of Epidemiology, Center for Public Health Sciences, National Cancer 
      Center, Tokyo, 104-0045, Japan.
FAU - Zheng, Wei
AU  - Zheng W
AD  - Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, 
      Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, 
      Nashville, TN, 37232, USA.
FAU - Bolla, Manjeet K
AU  - Bolla MK
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic 
      Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
FAU - Dunning, Alison M
AU  - Dunning AM
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic 
      Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
FAU - Easton, Douglas F
AU  - Easton DF
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic 
      Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
AD  - Department of Oncology, Centre for Cancer Genetic Epidemiology, University of 
      Cambridge, Cambridge, CB1 8RN, UK.
FAU - Pharoah, Paul D P
AU  - Pharoah PDP
AD  - Department of Public Health and Primary Care, Centre for Cancer Genetic 
      Epidemiology, University of Cambridge, Cambridge, CB1 8RN, UK.
AD  - Department of Oncology, Centre for Cancer Genetic Epidemiology, University of 
      Cambridge, Cambridge, CB1 8RN, UK.
FAU - Hartman, Mikael
AU  - Hartman M
AD  - Saw Swee Hock School of Public Health, National University of Singapore and 
      National University Health System, Singapore, 119077, Singapore.
AD  - Department of Surgery, National University Health System, Singapore, 119228, 
      Singapore.
FAU - Li, Jingmei
AU  - Li J
AUID- ORCID: 0000-0001-8587-7511
AD  - Women's Health and Genetics, Genome Institute of Singapore, 60 Biopolis Street, 
      Genome, #02-01, Singapore, 138672, Singapore. lijm1@gis.a-star.edu.sg.
AD  - Department of Surgery, National University Health System, Singapore, 119228, 
      Singapore. lijm1@gis.a-star.edu.sg.
LA  - eng
GR  - 203477/Z/16/Z/WT_/Wellcome Trust/United Kingdom
GR  - Applied Translational Research/Biomedical Research Council/
GR  - NRF-NRFF2017-02/National Research Foundation Singapore/
PT  - Journal Article
DEP - 20220511
PL  - Japan
TA  - Breast Cancer
JT  - Breast cancer (Tokyo, Japan)
JID - 100888201
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Alleles
MH  - Asian People/genetics
MH  - *Breast Neoplasms/genetics
MH  - Female
MH  - Genetic Predisposition to Disease
MH  - Genotype
MH  - *HLA Antigens/genetics
MH  - Humans
MH  - Polymorphism, Single Nucleotide
PMC - PMC9385763
OTO - NOTNLM
OT  - Breast cancer risk
OT  - Breast cancer subtypes
OT  - HLA
COIS- The authors declare no potential conflicts of interest.
EDAT- 2022/05/12 06:00
MHDA- 2022/08/20 06:00
PMCR- 2022/05/11
CRDT- 2022/05/11 11:22
PHST- 2022/01/30 00:00 [received]
PHST- 2022/04/22 00:00 [accepted]
PHST- 2022/05/12 06:00 [pubmed]
PHST- 2022/08/20 06:00 [medline]
PHST- 2022/05/11 11:22 [entrez]
PHST- 2022/05/11 00:00 [pmc-release]
AID - 10.1007/s12282-022-01366-w [pii]
AID - 1366 [pii]
AID - 10.1007/s12282-022-01366-w [doi]
PST - ppublish
SO  - Breast Cancer. 2022 Sep;29(5):869-879. doi: 10.1007/s12282-022-01366-w. Epub 2022 
      May 11.