PMID- 35544935
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231221
IS  - 1678-2925 (Electronic)
IS  - 0004-2749 (Linking)
VI  - 86
IP  - 5
DP  - 2022
TI  - Arterial hemodynamics and its correlation with retinal microarchitecture in 
      pseudoexfoliation glaucoma.
PG  - e20230065
LID - 10.5935/0004-2749.20230065 [doi]
AB  - PURPOSE: The study aimed to investigate the correlation between arterial 
      hemodynamics measured by color Doppler ultrasonography and retinal 
      microarchitecture parameters determined by spectral-domain optical coherence 
      tomography (SD-OCT) in pseudoexfoliation glaucoma. METHODS: This prospective 
      study included 82 participants. Peripapillary retinal nerve fiber layer, ganglion 
      cell inner plexiform layer, and ganglion cell complex values were measured. 
      Ophthalmic artery and central retinal artery flows were evaluated with color 
      Doppler ultrasonography, and resistivity index values were calculated. RESULTS: 
      The study included 47 controls and 35 pseudoexfoliation glaucoma cases. In 
      pseudoexfoliation glaucoma group, mean peripapillary retinal nerve fiber layer 
      and ganglion cell complex thickness were statistically significantly lower in all 
      quadrants compared to controls (p<0.001). Resistivity index values of the 
      ophthalmic and central retinal arteries were significantly higher in 
      pseudoexfoliation glaucoma group than in the controls (p<0.001 and r=0.684). 
      Resistivity index values of the ophthalmic and central retinal arteries with 
      ganglion cell complex thickness correlated significantly. On the other hand, no 
      significant relationship for retinal nerve fiber layer thickness was identified. 
      CONCLUSIONS: Structural changes (ganglion cell complex and ganglion cell inner 
      plexiform layer) in patients with pseudoexfoliation glaucoma and early 
      glaucomatous loss showed a significant correlation with changes in ocular 
      vascular hemodynamics. In cases where systemic vascular resistance is increased, 
      ganglion cell complex and ganglion cell inner plexiform layer may not exactly 
      reflect glaucoma state. In such cases, thickness changes in the retinal nerve 
      fiber layer may give more realistic results regarding glaucoma. We have seen that 
      pseudoexfoliation glaucoma-induced structural deterioration and increased 
      resistance in ocular hemodynamics correlated with ganglion cell complex, but not 
      retinal nerve fiber layer.
FAU - Kocaturk, Tolga
AU  - Kocaturk T
AUID- ORCID: 0000-0001-5187-227X
AD  - Department of Ophthalmology, Faculty of Medicine, Adnan Menderes University, 
      Aydin, Turkey.
FAU - Abdullayev, Ozge Key
AU  - Abdullayev OK
AD  - Department of Ophthalmology, Aydin State Hospital, Aydin, Turkey.
FAU - Bekmez, Sinan
AU  - Bekmez S
AUID- ORCID: 0000-0002-7849-2717
AD  - Department of Ophthalmology, University of Health Sciences Dr. Behcet Uz Child 
      Disease and Pediatric Surgery Training and Research Hospital, Izmir, Turkey.
FAU - Polat, Yasemin Durum
AU  - Polat YD
AD  - Department of Radiology, Faculty of Medicine, Adnan Menderes University, Aydin, 
      Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220509
PL  - Brazil
TA  - Arq Bras Oftalmol
JT  - Arquivos brasileiros de oftalmologia
JID - 0400645
SB  - IM
EDAT- 2022/05/12 06:00
MHDA- 2022/05/12 06:01
CRDT- 2022/05/11 17:34
PHST- 2021/06/09 00:00 [received]
PHST- 2021/12/13 00:00 [accepted]
PHST- 2022/05/12 06:01 [medline]
PHST- 2022/05/12 06:00 [pubmed]
PHST- 2022/05/11 17:34 [entrez]
AID - S0004-27492022005006211 [pii]
AID - 10.5935/0004-2749.20230065 [doi]
PST - epublish
SO  - Arq Bras Oftalmol. 2022 May 9;86(5):e20230065. doi: 10.5935/0004-2749.20230065. 
      eCollection 2022.