PMID- 35545457
OWN - NLM
STAT- MEDLINE
DCOM- 20220615
LR  - 20220802
IS  - 1532-8422 (Electronic)
IS  - 1053-0770 (Print)
IS  - 1053-0770 (Linking)
VI  - 36
IP  - 8 Pt B
DP  - 2022 Aug
TI  - Uninterrupted Continuation of VV-ECMO Without Anticoagulation for 44 Days in 
      COVID-19 ARDS: A Precarious Quandary.
PG  - 3193-3196
LID - S1053-0770(22)00265-8 [pii]
LID - 10.1053/j.jvca.2022.04.006 [doi]
AB  - Venovenous extracorporeal membrane oxygenation (VV-ECMO) has become a mainstay 
      treatment modality for a select patient population who do not respond to 
      conventional medical therapy suffering from severe acute respiratory distress 
      syndrome (ARDS) due to COVID-19. This therapy necessitates the utilization of 
      anticoagulation, whether unfractionated heparin or bivalirudin, to prevent 
      thrombotic complications. Scarce are reports of VV-ECMO implementation leading to 
      acute hemorrhage mandating cessation of anticoagulation in a patient suffering 
      from COVID-19 ARDS. Herein, the authors report a case of a successful outcome in 
      a COVID-19 ARDS patient who suffered an acute hemorrhagic complication leading to 
      pre-emptive termination of systemic anticoagulation. The authors believe this to 
      be one of the first such cases in the literature.
CI  - Copyright (c) 2022 Elsevier Inc. All rights reserved.
FAU - Patel, Sankalp P
AU  - Patel SP
AD  - Department of Internal Medicine, Graduate Medical Education, NCH Healthcare 
      System, Naples, FL. Electronic address: Sankalp.Patel@nchmd.org.
FAU - Solomon, Brian J
AU  - Solomon BJ
AD  - Department of Cardiothoracic Surgery, Naples Heart Institute, NCH Healthcare 
      System, Naples, FL.
FAU - Pascotto, Robert D
AU  - Pascotto RD
AD  - Department of Cardiothoracic Surgery, Naples Heart Institute, NCH Healthcare 
      System, Naples, FL.
FAU - D'Orazio, Stephen E
AU  - D'Orazio SE
AD  - Department of Cardiothoracic Surgery, Naples Heart Institute, NCH Healthcare 
      System, Naples, FL.
FAU - Navas, Elsy V
AU  - Navas EV
AD  - Department of Cardiology, Naples Heart Institute, NCH Healthcare System; Naples, 
      FL.
FAU - Cubeddu, Robert J
AU  - Cubeddu RJ
AD  - Department of Cardiology, Naples Heart Institute, NCH Healthcare System; Naples, 
      FL.
FAU - Cudemus, Gaston A
AU  - Cudemus GA
AD  - Department of Cardiovascular Critical Care, Naples Heart Institute, NCH 
      Healthcare System, Naples, FL.
LA  - eng
PT  - Case Reports
PT  - Journal Article
DEP - 20220410
PL  - United States
TA  - J Cardiothorac Vasc Anesth
JT  - Journal of cardiothoracic and vascular anesthesia
JID - 9110208
RN  - 0 (Anticoagulants)
RN  - 9005-49-6 (Heparin)
SB  - IM
MH  - Anticoagulants
MH  - *COVID-19/complications/therapy
MH  - *Extracorporeal Membrane Oxygenation
MH  - Hemorrhage
MH  - Heparin
MH  - Humans
MH  - *Respiratory Distress Syndrome/therapy
PMC - PMC8994674
OTO - NOTNLM
OT  - COVID-19
OT  - acute respiratory distress syndrome
OT  - anticoagulation
OT  - extracorporeal membrane oxygenation
OT  - hemorrhage
OT  - survival
OT  - thrombotic complications
COIS- Conflict of Interest None.
EDAT- 2022/05/12 06:00
MHDA- 2022/06/16 06:00
PMCR- 2022/04/10
CRDT- 2022/05/11 22:02
PHST- 2022/01/03 00:00 [received]
PHST- 2022/03/01 00:00 [revised]
PHST- 2022/04/05 00:00 [accepted]
PHST- 2022/05/12 06:00 [pubmed]
PHST- 2022/06/16 06:00 [medline]
PHST- 2022/05/11 22:02 [entrez]
PHST- 2022/04/10 00:00 [pmc-release]
AID - S1053-0770(22)00265-8 [pii]
AID - 10.1053/j.jvca.2022.04.006 [doi]
PST - ppublish
SO  - J Cardiothorac Vasc Anesth. 2022 Aug;36(8 Pt B):3193-3196. doi: 
      10.1053/j.jvca.2022.04.006. Epub 2022 Apr 10.