PMID- 35545823
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220512
IS  - 1552-6844 (Electronic)
IS  - 1545-9683 (Linking)
VI  - 31
IP  - 6
DP  - 2017 Jun
TI  - SCIPA Switch-On: A Randomized Controlled Trial Investigating the Efficacy and 
      Safety of Functional Electrical Stimulation-Assisted Cycling and Passive Cycling 
      Initiated Early After Traumatic Spinal Cord Injury.
PG  - 540-551
LID - 10.1177/1545968317697035 [doi]
AB  - Background. Substantial skeletal muscle atrophy after spinal cord injury (SCI) 
      carries significant repercussions for functional recovery and longer-term health. 
      Objective. To compare the efficacy, safety, and feasibility of functional 
      electrical stimulation-assisted cycling (FESC) and passive cycling (PC) to 
      attenuate muscle atrophy after acute SCI. Methods. This multicenter, 
      assessor-blinded phase I/II trial randomized participants at 4 weeks post-SCI to 
      FESC or PC (4 sessions per week, 1 hour maximum per session, over 12 weeks). The 
      primary outcome measure was mean maximum cross-sectional area (CSA) of thigh and 
      calf muscles (magnetic resonance imaging), and secondary outcome measures 
      comprised body composition (dual energy X-ray absorptiometry), anthropometry, 
      quality of life, and adverse events (AEs). Results. Of 24 participants, 19 
      completed the 12-week trial (10 FESC, 9 PC, 18 male). Those participants 
      completed >80% of training sessions (FESC, 83.5%; PC, 85.9%). No significant 
      between-group difference in postintervention muscle CSA was found. No significant 
      between-group difference was found for any other tissue, anthropometric 
      parameter, or behavioral variable or AEs. Six participants experienced thigh 
      hypertrophy (FESC = 3; PC = 3). Atrophy was attenuated (<30%) in 15 cases (FESC = 
      7; PC = 8). Conclusions. Both cycle ergometry regimens examined were safe, 
      feasible, and well tolerated early after SCI. No conclusions regarding efficacy 
      can be drawn from our data. Further investigation of both modalities early after 
      SCI is required.
FAU - Galea, Mary P
AU  - Galea MP
AD  - The University of Melbourne, Parkville, VIC, Australia.
FAU - Panisset, Maya G
AU  - Panisset MG
AD  - The University of Melbourne, Parkville, VIC, Australia.
FAU - El-Ansary, Doa
AU  - El-Ansary D
AD  - The University of Melbourne, Parkville, VIC, Australia.
FAU - Dunlop, Sarah A
AU  - Dunlop SA
AD  - The University of Western Australia, Crawley, Western Australia, Australia.
FAU - Marshall, Ruth
AU  - Marshall R
AD  - Hampstead Rehabilitation Centre, Northfield, South Australia, Australia.
FAU - Clark, Jillian M
AU  - Clark JM
AD  - Hampstead Rehabilitation Centre, Northfield, South Australia, Australia.
FAU - Churilov, Leonid
AU  - Churilov L
AD  - The University of Melbourne, Parkville, VIC, Australia.
CN  - SCIPA Switch-On Trial Collaborators<xref ref-type="fn" rid="fn1-1545968317697035" 
      ptype="f1545968317697035" citart="citart1">*</xref>
LA  - eng
PT  - Journal Article
DEP - 20170309
PL  - United States
TA  - Neurorehabil Neural Repair
JT  - Neurorehabilitation and neural repair
JID - 100892086
SB  - IM
OTO - NOTNLM
OT  - FES cycling
OT  - MRI
OT  - early exercise
OT  - muscle atrophy
OT  - passive cycling
OT  - randomized controlled trial
OT  - skeletal muscle
OT  - spinal cord injury
FIR - Hurley, Melanie
IR  - Hurley M
FIR - Nunn, Andrew
IR  - Nunn A
FIR - Alexander, Janette
IR  - Alexander J
FIR - Buchanan, John
IR  - Buchanan J
FIR - Nolan, Sherilyn
IR  - Nolan S
FIR - Atresh, Sridhar
IR  - Atresh S
FIR - Pick, Valerie
IR  - Pick V
FIR - Acland, Rick
IR  - Acland R
FIR - Nunnerley, Jo
IR  - Nunnerley J
EDAT- 2017/06/01 00:00
MHDA- 2017/06/01 00:01
CRDT- 2022/05/12 01:10
PHST- 2022/05/12 01:10 [entrez]
PHST- 2017/06/01 00:00 [pubmed]
PHST- 2017/06/01 00:01 [medline]
AID - 10.1177/1545968317697035 [doi]
PST - ppublish
SO  - Neurorehabil Neural Repair. 2017 Jun;31(6):540-551. doi: 
      10.1177/1545968317697035. Epub 2017 Mar 9.