PMID- 35547691 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2046-2069 (Electronic) IS - 2046-2069 (Linking) VI - 8 IP - 57 DP - 2018 Sep 18 TI - Recyclable Cu/C(3)N(4) composite catalyzed AHA/A(3) coupling reactions for the synthesis of propargylamines. PG - 32942-32947 LID - 10.1039/c8ra06613b [doi] AB - The heterogeneous Cu/C(3)N(4) catalyst was found to be efficient for the synthesis of propargylamines using a three-component coupling reaction of alkynes, CH(2)Cl(2) and amines (AHA) without additional base. Moreover, the catalyst also showed highly catalytic activity in the synthesis of C1-alkynylated tetrahydroisoquinolines (THIQs) via an A(3) reaction of alkynes, aldehydes and THIQ. The Cu/C(3)N(4)-catalyzed multicomponent reactions exhibited good functional group tolerance in most examples. Furthermore, the easily prepared Cu/C(3)N(4) catalyst could be recovered and reused conveniently over 5 times without losing catalytic activities. CI - This journal is (c) The Royal Society of Chemistry. FAU - Xu, Hang AU - Xu H AD - Department of Applied Chemistry, School of Material Science and Technology, Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China yaoxq@nuaa.edu.cn. FAU - Wang, Jun AU - Wang J AD - Department of Applied Chemistry, School of Material Science and Technology, Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China yaoxq@nuaa.edu.cn. FAU - Wang, Peng AU - Wang P AD - Department of Applied Chemistry, School of Material Science and Technology, Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China yaoxq@nuaa.edu.cn. FAU - Niu, Xiyu AU - Niu X AD - Department of Applied Chemistry, School of Material Science and Technology, Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China yaoxq@nuaa.edu.cn. FAU - Luo, Yidan AU - Luo Y AD - Department of Chemistry, School of Pharmacy, Nanjing Medical University Nanjing 211166 PR China. FAU - Zhu, Li AU - Zhu L AD - Department of Chemistry, School of Pharmacy, Nanjing Medical University Nanjing 211166 PR China. FAU - Yao, Xiaoquan AU - Yao X AUID- ORCID: 0000-0003-3589-1475 AD - Department of Applied Chemistry, School of Material Science and Technology, Nanjing University of Aeronautics and Astronautics Nanjing 210016 PR China yaoxq@nuaa.edu.cn. LA - eng PT - Journal Article DEP - 20180924 PL - England TA - RSC Adv JT - RSC advances JID - 101581657 PMC - PMC9086382 COIS- There are no conflicts to declare. EDAT- 2018/09/24 00:00 MHDA- 2018/09/24 00:01 PMCR- 2018/09/24 CRDT- 2022/05/13 11:16 PHST- 2018/08/06 00:00 [received] PHST- 2018/09/18 00:00 [accepted] PHST- 2022/05/13 11:16 [entrez] PHST- 2018/09/24 00:00 [pubmed] PHST- 2018/09/24 00:01 [medline] PHST- 2018/09/24 00:00 [pmc-release] AID - c8ra06613b [pii] AID - 10.1039/c8ra06613b [doi] PST - epublish SO - RSC Adv. 2018 Sep 24;8(57):32942-32947. doi: 10.1039/c8ra06613b. eCollection 2018 Sep 18.