PMID- 35550911
OWN - NLM
STAT- MEDLINE
DCOM- 20220628
LR  - 20220801
IS  - 1873-4995 (Electronic)
IS  - 0168-3659 (Linking)
VI  - 347
DP  - 2022 Jul
TI  - Split bullets loaded nanoparticles for amplified immunotherapy.
PG  - 199-210
LID - S0168-3659(22)00266-8 [pii]
LID - 10.1016/j.jconrel.2022.05.011 [doi]
AB  - Dendritic cells (DCs) play central role in adaptive antitumor immunity, while 
      their function is often hampered by low immunogenicity of tumor tissues and 
      surrounding hostile microenvironment. Herein, a "split bullets" loaded 
      nanoplatform that can bidirectionally injure mitochondria (MT) and endoplasmic 
      reticulum (ER) of tumor cells is developed. After cellular uptake, the released 
      "split bullets" separately target to different subcellular destinations and exert 
      distinct effects on DCs: (1) MT-targeted "bullet" recruits peripheral DCs into 
      tumor sites, due to its capability to trigger adenosine triphosphate release from 
      tumor cells; (2) ER-targeted "bullet" activates tumor-infiltrating DCs, which is 
      attributed to its ability to evoke calreticulin exposure on tumor cells. These 
      effects collectively improve the tropism and reactivity of DCs to tumor-specific 
      antigen in a two-pronged way. As a result of enhanced function of DCs in antigen 
      capture, treatment of the "split bullets" loaded nanoplatform ignites robust 
      immune response to suppress primary melanoma, and establishes systemic immune 
      memory against post-surgical tumor recurrence. Overall, this nanoplatform offers 
      a generalizable approach to boost DCs and augment immunotherapy.
CI  - Copyright (c) 2022 Elsevier B.V. All rights reserved.
FAU - Liu, Chendong
AU  - Liu C
AD  - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug, Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Li, Lian
AU  - Li L
AD  - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug, Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Lyu, Jiayan
AU  - Lyu J
AD  - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug, Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Xiang, Yucheng
AU  - Xiang Y
AD  - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug, Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Chen, Liqiang
AU  - Chen L
AD  - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug, Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Zhou, Zhou
AU  - Zhou Z
AD  - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug, Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China.
FAU - Huang, Yuan
AU  - Huang Y
AD  - Key Laboratory of Drug-Targeting and Drug Delivery System of the Education 
      Ministry and Sichuan Province, Sichuan Engineering Laboratory for Plant-Sourced 
      Drug, Sichuan Research Center for Drug Precision Industrial Technology, West 
      China School of Pharmacy, Sichuan University, Chengdu 610041, China. Electronic 
      address: huangyuan0@163.com.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220511
PL  - Netherlands
TA  - J Control Release
JT  - Journal of controlled release : official journal of the Controlled Release 
      Society
JID - 8607908
RN  - 0 (Cancer Vaccines)
RN  - 0 (Immunologic Factors)
SB  - IM
MH  - Adaptive Immunity
MH  - *Cancer Vaccines
MH  - Dendritic Cells
MH  - Humans
MH  - Immunologic Factors
MH  - Immunotherapy
MH  - *Melanoma
MH  - *Nanoparticles
MH  - Tumor Microenvironment
OTO - NOTNLM
OT  - Dendritic cell
OT  - Endoplasmic reticulum
OT  - Immunotherapy
OT  - Mitochondria
OT  - Nanoparticle
EDAT- 2022/05/14 06:00
MHDA- 2022/06/29 06:00
CRDT- 2022/05/13 13:00
PHST- 2022/01/26 00:00 [received]
PHST- 2022/04/23 00:00 [revised]
PHST- 2022/05/05 00:00 [accepted]
PHST- 2022/05/14 06:00 [pubmed]
PHST- 2022/06/29 06:00 [medline]
PHST- 2022/05/13 13:00 [entrez]
AID - S0168-3659(22)00266-8 [pii]
AID - 10.1016/j.jconrel.2022.05.011 [doi]
PST - ppublish
SO  - J Control Release. 2022 Jul;347:199-210. doi: 10.1016/j.jconrel.2022.05.011. Epub 
      2022 May 11.