PMID- 35551699
OWN - NLM
STAT- MEDLINE
DCOM- 20220930
LR  - 20230922
IS  - 1619-3997 (Electronic)
IS  - 0300-5577 (Linking)
VI  - 50
IP  - 8
DP  - 2022 Oct 26
TI  - The effect of advanced maternal age on perinatal outcomes in nulliparous 
      pregnancies.
PG  - 1087-1095
LID - 10.1515/jpm-2021-0298 [doi]
AB  - OBJECTIVES: In the current study, we aimed to evaluate the effect of advanced 
      maternal age on perinatal outcomes in nulliparous singleton pregnancy. METHODS: 
      The perinatal outcome data of 11,366 patients who gave birth between 2015 and 
      2020 were evaluated retrospectively. Patients were subgrouped according to their 
      age as control group (C) (20-29 years), late advanced maternal age group 
      (30-34 years), advanced maternal age group (35-39 years), and very advanced 
      maternal age group (>/=40 years). Multinomial logistic regression analyses were 
      performed to test the possible independent role of maternal age as a risk factor 
      for adverse pregnancy outcomes. RESULTS: Statistically significant difference was 
      observed between the control group and the other groups in terms of preterm 
      delivery, preeclampsia, gestational diabetes mellitus (GDM), small gestational 
      age (SGA), large gestational age (LGA), premature rupture of membranes (PROM), 
      high birth weight (HBW), and perinatal mortality rates (p<0.05). An increased 
      risk of the need for neonatal intensive care unit (NICU) and perinatal mortality 
      was observed in groups over 35 years old. CONCLUSIONS: Age poses a risk in terms 
      of preterm delivery, preeclampsia, LGA, GDM, and HBW in the groups over 30 years 
      of maternal age. The rates of PROM, NICU, and perinatal mortality increase in 
      addition to those perinatal results in the groups above 35 years of maternal age.
CI  - (c) 2022 Walter de Gruyter GmbH, Berlin/Boston.
FAU - Elci, Gulhan
AU  - Elci G
AUID- ORCID: 0000-0003-2350-2567
AD  - Department of Obstetrics and Gynecology, University of Health Sciences Sancaktepe 
      Training and Research Hospital, Istanbul, Turkey.
FAU - Cakmak, Aysegul
AU  - Cakmak A
AUID- ORCID: 0000-0001-6228-8562
AD  - Department of Obstetrics and Gynecology, University of Health Sciences Umraniye 
      Training and Research Hospital, Istanbul, Turkey.
FAU - Elci, Erkan
AU  - Elci E
AUID- ORCID: 0000-0002-9792-6592
AD  - Department of Obstetrics and Gynecology, University of Health Sciences Umraniye 
      Training and Research Hospital, Istanbul, Turkey.
FAU - Sayan, Sena
AU  - Sayan S
AUID- ORCID: 0000-0001-6758-1127
AD  - Department of Obstetrics and Gynecology, Marmara University Faculty of Medicine, 
      Istanbul, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20220513
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
SB  - IM
MH  - Adult
MH  - Birth Weight
MH  - *Diabetes, Gestational/epidemiology
MH  - Female
MH  - Humans
MH  - Infant, Newborn
MH  - Maternal Age
MH  - *Perinatal Death
MH  - *Pre-Eclampsia/epidemiology
MH  - Pregnancy
MH  - *Pregnancy Complications
MH  - Pregnancy Outcome/epidemiology
MH  - *Premature Birth/epidemiology/etiology
MH  - Retrospective Studies
MH  - Young Adult
OTO - NOTNLM
OT  - advanced maternal age
OT  - maternal age
OT  - nulliparity
OT  - perinatal outcomes
OT  - pregnancy outcomes
EDAT- 2022/05/14 06:00
MHDA- 2022/10/01 06:00
CRDT- 2022/05/13 13:46
PHST- 2021/06/17 00:00 [received]
PHST- 2022/04/01 00:00 [accepted]
PHST- 2022/05/14 06:00 [pubmed]
PHST- 2022/10/01 06:00 [medline]
PHST- 2022/05/13 13:46 [entrez]
AID - jpm-2021-0298 [pii]
AID - 10.1515/jpm-2021-0298 [doi]
PST - epublish
SO  - J Perinat Med. 2022 May 13;50(8):1087-1095. doi: 10.1515/jpm-2021-0298. Print 
      2022 Oct 26.