PMID- 35556239
OWN - NLM
STAT- MEDLINE
DCOM- 20220909
LR  - 20220909
IS  - 1439-4286 (Electronic)
IS  - 0018-5043 (Linking)
VI  - 54
IP  - 9
DP  - 2022 Sep
TI  - Altered Circulating Leptin, hGH, and IGF-I in Prediabetes and Screening-Diagnosed 
      T2DM Unrelated to Metabolic Syndrome in Women Post Gestational Diabetes.
PG  - 613-619
LID - 10.1055/a-1850-5392 [doi]
AB  - Recently, we proposed two pathophysiologic subtypes of type 2 diabetes mellitus 
      (T2DM), one related and one unrelated to metabolic syndrome. To begin to 
      understand the pathophysiology of the subtype unrelated to metabolic syndrome, we 
      now measured selected hormones and signaling molecules in affected individuals. 
      In this cross-sectional analysis, we examined 138 women out of the monocenter, 
      post gestational diabetes study PPSDiab. Of these women, 73 had prediabetes or 
      screening-diagnosed T2DM, 40 related to metabolic syndrome and 33 unrelated. The 
      remaining 65 women were normoglycemic controls. Our analysis included medical 
      history, anthropometrics, oral glucose tolerance testing, laboratory chemistry, 
      and cardiopulmonary exercise testing. In addition, plasma proinsulin/insulin 
      ratio, growth hormone (hGH) nadir during oral glucose tolerance testing, 
      Insulin-like Growth Factor I (IGF-I), Leptin, Resistin, Adiponectin, Fetuin-a, 
      FGF21, and myostatin were measured. Compared to controls, women with prediabetes 
      or screening-diagnosed T2DM unrelated to metabolic syndrome depicted higher 
      plasma Leptin [10.47(6.6-14.57) vs. 5.52(3.15-10.02); p<0.0001] and IGF-I 
      [193.01(171.00-213.30) vs. 167.97(138.77-200.64); p=0.0008], as well as a lower 
      hGH nadir [0.07(0.05-0.15) vs. 0.14(0.08-0.22; p<0.0001]. These differences were 
      independent of body adiposity. Women with prediabetes or T2DM related to 
      metabolic syndrome, in comparison to controls, displayed elevated Leptin, 
      Fetuin-a, and FGF21, as well as reduced Adiponectin and hGH nadir. Based on our 
      study, altered Leptin and hGH/IGF-I signaling could potentially contribute to the 
      pathophysiology of prediabetes and T2DM unrelated to metabolic syndrome. Further 
      mechanistic investigations of these signaling pathways in the context of lean 
      T2DM are necessary to test causal relationships.
CI  - Thieme. All rights reserved.
FAU - Kern-Matschilles, Stefanie
AU  - Kern-Matschilles S
AD  - Diabetes Research Group, LMU Klinikum Munchen, Medizinische Klinik und Poliklinik 
      IV, Munchen, Germany.
AD  - Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum Munchen, 
      Neuherberg, Germany.
AD  - (DZD), German Center for Diabetes Research, Neuherberg, Germany.
FAU - Gar, Christina
AU  - Gar C
AD  - Diabetes Research Group, LMU Klinikum Munchen, Medizinische Klinik und Poliklinik 
      IV, Munchen, Germany.
AD  - Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum Munchen, 
      Neuherberg, Germany.
AD  - (DZD), German Center for Diabetes Research, Neuherberg, Germany.
FAU - Schilbach, Katharina
AU  - Schilbach K
AD  - Endocrine Research Unit, LMU Klinikum Munchen, Medizinische Klinik IV, Munchen, 
      Germany.
FAU - Haschka, Stefanie Julia
AU  - Haschka SJ
AD  - Diabetes Research Group, LMU Klinikum Munchen, Medizinische Klinik und Poliklinik 
      IV, Munchen, Germany.
AD  - Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum Munchen, 
      Neuherberg, Germany.
AD  - (DZD), German Center for Diabetes Research, Neuherberg, Germany.
FAU - Rauch, Barbara
AU  - Rauch B
AD  - Diabetes Research Group, LMU Klinikum Munchen, Medizinische Klinik und Poliklinik 
      IV, Munchen, Germany.
AD  - Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum Munchen, 
      Neuherberg, Germany.
AD  - (DZD), German Center for Diabetes Research, Neuherberg, Germany.
FAU - Then, Cornelia
AU  - Then C
AD  - Diabetes Research Group, LMU Klinikum Munchen, Medizinische Klinik und Poliklinik 
      IV, Munchen, Germany.
AD  - Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum Munchen, 
      Neuherberg, Germany.
AD  - (DZD), German Center for Diabetes Research, Neuherberg, Germany.
FAU - Seissler, Jochen
AU  - Seissler J
AD  - Diabetes Research Group, LMU Klinikum Munchen, Medizinische Klinik und Poliklinik 
      IV, Munchen, Germany.
AD  - Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum Munchen, 
      Neuherberg, Germany.
AD  - (DZD), German Center for Diabetes Research, Neuherberg, Germany.
FAU - Bidlingmaier, Martin
AU  - Bidlingmaier M
AD  - Endocrine Research Unit, LMU Klinikum Munchen, Medizinische Klinik IV, Munchen, 
      Germany.
FAU - Lechner, Andreas
AU  - Lechner A
AD  - Clinical Research Group, LMU Klinikum Munchen, Medizinische Klinik und Poliklinik 
      4, Munchen, Germany.
AD  - Clinical Cooperation Group Type 2 Diabetes, Helmholtz Zentrum Munchen, 
      Neuherberg, Germany.
AD  - (DZD), German Center for Diabetes Research, Neuherberg, Germany.
LA  - eng
PT  - Journal Article
DEP - 20220512
PL  - Germany
TA  - Horm Metab Res
JT  - Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et 
      metabolisme
JID - 0177722
RN  - 0 (Adiponectin)
RN  - 0 (Leptin)
RN  - 0 (alpha-2-HS-Glycoprotein)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adiponectin
MH  - Body Mass Index
MH  - Cross-Sectional Studies
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - *Diabetes, Gestational
MH  - Female
MH  - Humans
MH  - Insulin-Like Growth Factor I
MH  - Leptin
MH  - *Metabolic Syndrome/diagnosis
MH  - *Prediabetic State/diagnosis
MH  - Pregnancy
MH  - alpha-2-HS-Glycoprotein
COIS- The authors declare that they have no conflict of interest.
EDAT- 2022/05/14 06:00
MHDA- 2022/09/11 06:00
CRDT- 2022/05/13 17:07
PHST- 2022/05/14 06:00 [pubmed]
PHST- 2022/09/11 06:00 [medline]
PHST- 2022/05/13 17:07 [entrez]
AID - 10.1055/a-1850-5392 [doi]
PST - ppublish
SO  - Horm Metab Res. 2022 Sep;54(9):613-619. doi: 10.1055/a-1850-5392. Epub 2022 May 
      12.