PMID- 35558073
OWN - NLM
STAT- MEDLINE
DCOM- 20220519
LR  - 20220716
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 13
DP  - 2022
TI  - Rapid Inflammasome Activation Is Attenuated in Post-Myocardial Infarction 
      Monocytes.
PG  - 857455
LID - 10.3389/fimmu.2022.857455 [doi]
LID - 857455
AB  - Inflammasomes are crucial gatekeepers of the immune response, but their 
      maladaptive activation associates with inflammatory pathologies. Besides 
      canonical activation, monocytes can trigger non-transcriptional or rapid 
      inflammasome activation that has not been well defined in the context of acute 
      myocardial infarction (AMI). Rapid transcription-independent inflammasome 
      activation induced by simultaneous TLR priming and triggering stimulus was 
      measured by caspase-1 (CASP1) activity and interleukin release. Both classical 
      and intermediate monocytes from healthy donors exhibited robust CASP1 activation, 
      but only classical monocytes produced high mature interleukin-18 (IL18) release. 
      We also recruited a limited number of coronary artery disease (CAD, n=31) and AMI 
      (n=29) patients to evaluate their inflammasome function and expression profiles. 
      Surprisingly, monocyte subpopulations isolated from blood collected during 
      percutaneous coronary intervention (PCI) from AMI patients presented diminished 
      CASP1 activity and abrogated IL18 release despite increased NLRP3 gene 
      expression. This unexpected attenuated rapid inflammasome activation was 
      accompanied by a significant increase of TNFAIP3 and IRAKM expression. Moreover, 
      TNFAIP3 protein levels of circulating monocytes showed positive correlation with 
      high sensitive troponin T (hsTnT), implying an association between TNFAIP3 
      upregulation and the severity of tissue injury. We suggest this monocyte 
      attenuation to be a protective phenotype aftermath following a very early 
      inflammatory wave in the ischemic area. Damage-associated molecular patterns 
      (DAMPs) or other signals trigger a transitory negative feedback loop within newly 
      recruited circulating monocytes as a mechanism to reduce post-injury tissue 
      damage.
CI  - Copyright (c) 2022 Giral, Franke, Moobed, Muller, Lubking, James, Hartung, 
      Kuschnerus, Meteva, Seppelt, Jakob, Klingenberg, Krankel, Leistner, Zeller, 
      Blankenberg, Zimmermann, Haghikia, Luscher, Akalin, Landmesser and Kratzer.
FAU - Giral, Hector
AU  - Giral H
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
FAU - Franke, Vedran
AU  - Franke V
AD  - Max Delbruck Center, The Berlin Institute for Medical Systems Biology, Berlin, 
      Germany.
FAU - Moobed, Minoo
AU  - Moobed M
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
FAU - Muller, Maja F
AU  - Muller MF
AD  - Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
FAU - Lubking, Laura
AU  - Lubking L
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
FAU - James, Divya Maria
AU  - James DM
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
FAU - Hartung, Johannes
AU  - Hartung J
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
FAU - Kuschnerus, Kira
AU  - Kuschnerus K
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
FAU - Meteva, Denitsa
AU  - Meteva D
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
FAU - Seppelt, Claudio
AU  - Seppelt C
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
FAU - Jakob, Philipp
AU  - Jakob P
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
AD  - Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
AD  - Berlin Institute of Health at Charite - Universitatsmedizin Berlin, Berlin, 
      Germany.
FAU - Klingenberg, Roland
AU  - Klingenberg R
AD  - Department of Cardiology, University Hospital Zurich, Zurich, Switzerland.
FAU - Krankel, Nicolle
AU  - Krankel N
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
FAU - Leistner, David
AU  - Leistner D
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
AD  - Berlin Institute of Health at Charite - Universitatsmedizin Berlin, Berlin, 
      Germany.
FAU - Zeller, Tanja
AU  - Zeller T
AD  - Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany.
AD  - DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Lubeck, 
      Kiel, Hamburg, Germany.
FAU - Blankenberg, Stefan
AU  - Blankenberg S
AD  - Department of Cardiology, University Heart and Vascular Center, Hamburg, Germany.
AD  - DZHK (German Center for Cardiovascular Research), Partner Site Hamburg, Lubeck, 
      Kiel, Hamburg, Germany.
FAU - Zimmermann, Friederike
AU  - Zimmermann F
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
FAU - Haghikia, Arash
AU  - Haghikia A
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
FAU - Luscher, Thomas F
AU  - Luscher TF
AD  - Center for Molecular Cardiology, University of Zurich, Zurich, Switzerland.
FAU - Akalin, Altuna
AU  - Akalin A
AD  - Max Delbruck Center, The Berlin Institute for Medical Systems Biology, Berlin, 
      Germany.
FAU - Landmesser, Ulf
AU  - Landmesser U
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
AD  - Berlin Institute of Health at Charite - Universitatsmedizin Berlin, Berlin, 
      Germany.
FAU - Kratzer, Adelheid
AU  - Kratzer A
AD  - Department of Cardiology, Charite - Universitatsmedizin Berlin, Corporate Member 
      of Freie Universitat Berlin, Humboldt-Universitat zu Berlin, Berlin, Germany.
AD  - DZHK (German Centre for Cardiovascular Research), Partner Site Berlin, Berlin, 
      Germany.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220426
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-18)
RN  - 0 (Interleukin-1beta)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
SB  - IM
MH  - Humans
MH  - Inflammasomes/metabolism
MH  - Interleukin-18/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Monocytes
MH  - *Myocardial Infarction/pathology
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - *Percutaneous Coronary Intervention
PMC - PMC9090500
OTO - NOTNLM
OT  - IRAKM
OT  - TNFAIP3 (A20)
OT  - acute myocardial infarction
OT  - inflammasome
OT  - interleukin 18
OT  - monocytes
OT  - refractory behavior
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/14 06:00
MHDA- 2022/05/20 06:00
PMCR- 2022/01/01
CRDT- 2022/05/13 18:10
PHST- 2022/01/19 00:00 [received]
PHST- 2022/03/28 00:00 [accepted]
PHST- 2022/05/13 18:10 [entrez]
PHST- 2022/05/14 06:00 [pubmed]
PHST- 2022/05/20 06:00 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2022.857455 [doi]
PST - epublish
SO  - Front Immunol. 2022 Apr 26;13:857455. doi: 10.3389/fimmu.2022.857455. eCollection 
      2022.