PMID- 35558752
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220518
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Structure and Bioactivities of a Novel Polysaccharide Extracted From Dendrobium 
      huoshanense by Subcritical Water.
PG  - 877871
LID - 10.3389/fnut.2022.877871 [doi]
LID - 877871
AB  - In this study, the polysaccharide was extracted by subcritical water from 
      Dendrobium huoshanense. A novel polysaccharide (DHPs-1) was obtained through 
      several purification steps and its structure and bioactivity were investigated. 
      Structural analysis indicated that the weight-average molecular weight of DHPs-1 
      was 5.0 x 10(4) Da and it was mainly composed of glucose (65.04%), mannose 
      (14.23%), galactose (8.17%), galacturonic acid (6.41%), rhamnose (2.34%), and 
      xylose (1.25%). 1,4-Glcp, and 1,4,6-Galp were existed in the backbone of DHPs-1. 
      The residues of 1,3,4-Galp, 1,4-Manp, 1,4-Galp, and 1,3,4,6-Galp could be in the 
      backbone or the side chains with the non-reducing terminal of alpha-Manp. Bioactivity 
      tests indicated that DHPs-1 had immunomodulatory activity in that it 
      significantly enhanced transcript levels of cytokines [Tumor necrosis factor-alpha 
      (TNF-alpha), Interleukin-6 (IL-6), Interleukin-1beta (IL-1beta), and Interleukin-10 
      (IL-10)]. DPPH and hydroxyl radical scavenging tests showed that it had good 
      antioxidant activity. These results reveal that DHPs-1 could be developed as a 
      safe immunomodulatory agent and antioxidant for pharmacological or functional 
      food applications.
CI  - Copyright (c) 2022 Wang, Mao, Zeng, Liu, Niu, Li, Ma, Guo and Yang.
FAU - Wang, Li
AU  - Wang L
AD  - The Modernization Engineering Technology Research Center of Ethnic Minority 
      Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central 
      University for Nationalities, Wuhan, China.
AD  - Department of Traditional Chinese Medicine, Henan Agricultural University, 
      Zhengzhou, China.
FAU - Mao, Yi-Gui
AU  - Mao YG
AD  - The Modernization Engineering Technology Research Center of Ethnic Minority 
      Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central 
      University for Nationalities, Wuhan, China.
FAU - Zeng, Xiang
AU  - Zeng X
AD  - The Modernization Engineering Technology Research Center of Ethnic Minority 
      Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central 
      University for Nationalities, Wuhan, China.
FAU - Liu, Na
AU  - Liu N
AD  - The Modernization Engineering Technology Research Center of Ethnic Minority 
      Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central 
      University for Nationalities, Wuhan, China.
FAU - Niu, Chao-Fei
AU  - Niu CF
AD  - Department of Traditional Chinese Medicine, Henan Agricultural University, 
      Zhengzhou, China.
FAU - Li, Xin-Xin
AU  - Li XX
AD  - Department of Traditional Chinese Medicine, Henan Agricultural University, 
      Zhengzhou, China.
FAU - Ma, Bing-Ji
AU  - Ma BJ
AD  - Department of Traditional Chinese Medicine, Henan Agricultural University, 
      Zhengzhou, China.
FAU - Guo, Lan-Ping
AU  - Guo LP
AD  - State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for 
      Chinese Materia Medical, China Academy of Chinese Medical Sciences, Beijing, 
      China.
FAU - Yang, Xiao-Long
AU  - Yang XL
AD  - The Modernization Engineering Technology Research Center of Ethnic Minority 
      Medicine of Hubei Province, School of Pharmaceutical Sciences, South-Central 
      University for Nationalities, Wuhan, China.
LA  - eng
PT  - Journal Article
DEP - 20220426
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9087634
OTO - NOTNLM
OT  - Dendrobium huoshanense
OT  - bioactivities
OT  - polysaccharide
OT  - structure
OT  - subcritical water
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/14 06:00
MHDA- 2022/05/14 06:01
PMCR- 2022/01/01
CRDT- 2022/05/13 18:19
PHST- 2022/02/17 00:00 [received]
PHST- 2022/03/21 00:00 [accepted]
PHST- 2022/05/13 18:19 [entrez]
PHST- 2022/05/14 06:00 [pubmed]
PHST- 2022/05/14 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.877871 [doi]
PST - epublish
SO  - Front Nutr. 2022 Apr 26;9:877871. doi: 10.3389/fnut.2022.877871. eCollection 
      2022.