PMID- 35561274
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220531
IS  - 1557-7600 (Electronic)
IS  - 1096-620X (Linking)
VI  - 25
IP  - 5
DP  - 2022 May
TI  - Salicornia herbacea Aqueous Extracts Regulate NLRP3 Inflammasome Activation in 
      Macrophages and Trophoblasts.
PG  - 503-512
LID - 10.1089/jmf.2021.K.0154 [doi]
AB  - Salicornia herbacea L. (Chenopodiaceae), an edible salt marsh plant with 
      anti-inflammatory effects, was examined in macrophages and trophoblasts whether 
      it modulates NLRP3 inflammasome activity. Pretreatment and delayed treatment of 
      S. herbacea extract (SHE) in bone marrow-derived macrophages (BMDMs) reduced the 
      activity of NLRP3 inflammasome induced by lipopolysaccharide (LPS) and adenosine 
      triphosphate stimulation and downregulated interleukin (IL)-1beta production. SHE 
      also inhibited pyroptotic cell death, the adaptor molecule apoptosis-associated 
      speck-like protein containing a CARD (ASC), oligomerization, and speck by NLRP3 
      inflammasome activity in BMDM. Similarly, SHE decreased the mRNA expression of 
      NLRP3, ASC, IL-1beta, and IL-6 in the LPS-stimulated human trophoblast cell line, 
      Swan 71 cells. In addition, SHE inhibited the production of IL-6 and IL-1beta and 
      decreased the expression of cyclooxygenase-2 and prostaglandin E2 in stimulated 
      Swan 71 cells. Finally, 3,5-dicaffeoylquinic acid (3,5-DCQA), one of the 
      components of S. herbacea, inhibited IL-1beta produced by NLRP3 inflammasome 
      activity. In conclusion, SHE downregulated the activity of the NLRP3 inflammasome 
      in macrophages and trophoblasts.
FAU - Noh, Eui-Jeong
AU  - Noh EJ
AUID- ORCID: 0000-0003-2567-9649
AD  - Department of Obstetrics and Gynecology, College of Medicine, Myunggok Medical 
      Research Institute, Konyang University, Daejeon, Korea.
FAU - Lee, Jun-Young
AU  - Lee JY
AD  - KIBIO Co., Ltd., Daejeon, Korea.
FAU - Park, Seo-Ye
AU  - Park SY
AD  - Department of Obstetrics and Gynecology, College of Medicine, Myunggok Medical 
      Research Institute, Konyang University, Daejeon, Korea.
FAU - Park, Jong-Hwan
AU  - Park JH
AD  - Laboratory Animal Medicine, College of Veterinary Medicine and BK 21 PLUS Project 
      Team, Chonnam National University, Gwangju, Korea.
FAU - Cho, Jeong-Yong
AU  - Cho JY
AD  - Department of Food Science and Technology, Chonnam National University, Gwangju, 
      Korea.
FAU - Kim, Young-Min
AU  - Kim YM
AUID- ORCID: 0000-0002-2559-9182
AD  - Department of Food Science and Technology, Chonnam National University, Gwangju, 
      Korea.
FAU - Kim, Jong-Seok
AU  - Kim JS
AD  - Myunggok Medical Research Institute, College of Medicine, Konyang University, 
      Daejeon, Korea.
FAU - Lee, Ki-Mo
AU  - Lee KM
AD  - Department of Obstetrics and Gynecology, College of Medicine, Myunggok Medical 
      Research Institute, Konyang University, Daejeon, Korea.
FAU - Choi, Sunga
AU  - Choi S
AD  - Department of Bioinformatics & Biosystems, Seongnam Campus of Korea Polytechnics, 
      Gyeonggi-do, Korea.
FAU - Lee, Sung Ki
AU  - Lee SK
AUID- ORCID: 0000-0002-6941-192X
AD  - Department of Obstetrics and Gynecology, College of Medicine, Myunggok Medical 
      Research Institute, Konyang University, Daejeon, Korea.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Med Food
JT  - Journal of medicinal food
JID - 9812512
RN  - 0 (Inflammasomes)
RN  - 0 (Interleukin-1beta)
RN  - 0 (Interleukin-6)
RN  - 0 (Lipopolysaccharides)
RN  - 0 (NLR Family, Pyrin Domain-Containing 3 Protein)
RN  - 0 (NLRP3 protein, human)
RN  - EC 3.4.22.36 (Caspase 1)
SB  - IM
MH  - Caspase 1/metabolism/pharmacology
MH  - *Chenopodiaceae
MH  - Humans
MH  - *Inflammasomes
MH  - Inflammation/metabolism
MH  - Interleukin-1beta/metabolism
MH  - Interleukin-6/genetics/metabolism
MH  - Lipopolysaccharides/pharmacology
MH  - Macrophages
MH  - NLR Family, Pyrin Domain-Containing 3 Protein/metabolism
MH  - Trophoblasts/metabolism
OTO - NOTNLM
OT  - NLRP3 inflammasome
OT  - Salicornia herbacea L.
OT  - inflammation
OT  - macrophage
OT  - trophoblast
EDAT- 2022/05/14 06:00
MHDA- 2022/05/18 06:00
CRDT- 2022/05/13 19:45
PHST- 2022/05/13 19:45 [entrez]
PHST- 2022/05/14 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
AID - 10.1089/jmf.2021.K.0154 [doi]
PST - ppublish
SO  - J Med Food. 2022 May;25(5):503-512. doi: 10.1089/jmf.2021.K.0154.