PMID- 35562706
OWN - NLM
STAT- MEDLINE
DCOM- 20220518
LR  - 20220615
IS  - 1472-6874 (Electronic)
IS  - 1472-6874 (Linking)
VI  - 22
IP  - 1
DP  - 2022 May 13
TI  - Clinical and MRI features of sacral insufficiency fractures after radiotherapy in 
      patients with cervical cancer.
PG  - 166
LID - 10.1186/s12905-022-01758-2 [doi]
LID - 166
AB  - BACKGROUND: To determine the incidence, clinical and MRI features of sacral 
      insufficiency fracture (SIF) after radiotherapy (RT) in patients with cervical 
      cancer. METHODS: Our study included 167 patients with cervical cancer after 
      radiotherapy that underwent pelvic MRI for follow-up. MRIs included pre-enhanced 
      T1-weighted, coronal fat-Suppressed T2-weighted (FS-T2W) and enhanced T1-weighted 
      imaging. The clinical and MRI dates were reviewed. The gold standard of SIF was 
      based on radiologic findings, clinical data and follow-up at least 12 months. 
      RESULTS: 28 patients (10.8%) with 47 sites were diagnosed with SIFs, including 9 
      patients with unilateral SIF and 19 patients with bilateral SIFs. The median age 
      was 60 years (range 41-72 years), and 89.3% (25/28) of patients were 
      postmenopausal. 64.3% (18/28) of patients were symptomatic, and 53.6% of patients 
      (15/28) had concomitant pelvic fractures. The median interval time from RT to 
      SIFs was 10 months (range 3-34 months). For the lesion-wise analysis based on all 
      MR images, all lesions were detected by visualizing bone marrow edema patterns, 
      and fracture lines were detected in 64.6% (31/47) of SIFs. No soft-tissue tumors 
      were founded. For each MRI sequence analysis, coronal FS-T2WI detected the most 
      bone marrow edema pattern and fracture line than T1WI or enhanced T1WI. 
      CONCLUSION: SIF is a common complication in cervical cancer after radiotherapy, 
      which has some certain clinical and MRI features. Coronal FS-T2WI may be more 
      useful to detect and characterize these fractures than other imaging sequences.
CI  - (c) 2022. The Author(s).
FAU - Zhong, Xi
AU  - Zhong X
AD  - Department of Medical Imaging, Affiliated Cancer Hospital & Institute of 
      Guangzhou Medical University, Guangzhou, 510095, People's Republic of China.
FAU - Zhang, Linqi
AU  - Zhang L
AD  - Department of Nuclear Medicine, Affiliated Cancer Hospital & Institute of 
      Guangzhou Medical University, Guangzhou, 510095, People's Republic of China.
FAU - Dong, Tianfa
AU  - Dong T
AD  - Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou, 510150, People's Republic of China.
FAU - Mai, Hui
AU  - Mai H
AD  - Department of Radiology, The Third Affiliated Hospital of Guangzhou Medical 
      University, Guangzhou, 510150, People's Republic of China.
FAU - Lu, Bingui
AU  - Lu B
AD  - Department of Medical Imaging, Affiliated Cancer Hospital & Institute of 
      Guangzhou Medical University, Guangzhou, 510095, People's Republic of China.
FAU - Huang, Lu
AU  - Huang L
AD  - Department of Medical Imaging, Affiliated Cancer Hospital & Institute of 
      Guangzhou Medical University, Guangzhou, 510095, People's Republic of China.
FAU - Li, Jiansheng
AU  - Li J
AD  - Department of Medical Imaging, Affiliated Cancer Hospital & Institute of 
      Guangzhou Medical University, Guangzhou, 510095, People's Republic of China. 
      lijiansheng@gzhmu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20220513
PL  - England
TA  - BMC Womens Health
JT  - BMC women's health
JID - 101088690
SB  - IM
MH  - Adult
MH  - Aged
MH  - Female
MH  - *Fractures, Stress/diagnostic imaging/etiology
MH  - Humans
MH  - Magnetic Resonance Imaging/methods
MH  - Middle Aged
MH  - Retrospective Studies
MH  - Sacrum/diagnostic imaging
MH  - *Spinal Fractures/complications/etiology
MH  - *Uterine Cervical Neoplasms/complications/diagnostic imaging/radiotherapy
PMC - PMC9102937
OTO - NOTNLM
OT  - Cervical cancer
OT  - Insufficiency fracture
OT  - Magnetic resonance imaging
OT  - Radiotherapy
COIS- The authors declare that they have no competing interests.
EDAT- 2022/05/14 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/05/13
CRDT- 2022/05/13 23:36
PHST- 2020/08/31 00:00 [received]
PHST- 2022/05/05 00:00 [accepted]
PHST- 2022/05/13 23:36 [entrez]
PHST- 2022/05/14 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/05/13 00:00 [pmc-release]
AID - 10.1186/s12905-022-01758-2 [pii]
AID - 1758 [pii]
AID - 10.1186/s12905-022-01758-2 [doi]
PST - epublish
SO  - BMC Womens Health. 2022 May 13;22(1):166. doi: 10.1186/s12905-022-01758-2.