PMID- 35563797 OWN - NLM STAT- MEDLINE DCOM- 20220518 LR - 20230308 IS - 2073-4409 (Electronic) IS - 2073-4409 (Linking) VI - 11 IP - 9 DP - 2022 Apr 29 TI - Changes in Inflammatory Markers in Patients with Chronic Thromboembolic Pulmonary Hypertension Treated with Balloon Pulmonary Angioplasty. LID - 10.3390/cells11091491 [doi] LID - 1491 AB - Background: Inflammatory response and endothelial dysfunction contribute to the progression of chronic thromboembolic pulmonary hypertension (CTEPH). We aimed to assess changes in biomarkers involved in those processes in inoperable CTEPH patients treated with balloon pulmonary angioplasty (BPA). Methods: We enrolled 20 patients with inoperable CTEPH qualified for BPA and a control group. Interleukin 6, 8, 10 (IL-6, IL-8, IL-10), monocyte chemoattractant protein-1 (MCP-1), and C-reactive protein (hsCRP) constituted the markers of systemic inflammation. Endothelin 1 (ET-1) served as a marker of endothelial dysfunction. Selected markers were assessed before the BPA treatment, 24 h after the first BPA, and six months after completion of the BPA treatment. Results: At baseline, the CTEPH patients had increased serum concentrations of IL-6, IL-8 and ET-1. Twenty-four hours after a BPA session, we observed an increase in concentrations of IL-6 (∆ = 3.67 (1.41; 7.16); p < 0.001), of IL-10 (∆ = 0.25 (0; 0.47); p = 0.003), of MCP-1 (∆ = 111 (60.1; 202.8); p = 0.002), and of hsCRP (∆ = 4.81 (3.46; 8.47); p < 0.001). Six months after completion of the BPA treatment, there was a decrease in concentrations of IL-6 (∆ = -1.61 (-3.11; -0.20); p = 0.03), of IL8 (∆ = -3.24 (-7.72; 0.82); p = 0.01), and of ET-1 (∆ = -0.47 (-0.96; 0.05); p = 0.005). Conclusions: Patients with inoperable CTEPH exhibit increased systemic inflammation and endothelial dysfunction, which improves after completion of the BPA treatment. A single BPA session evokes an acute inflammatory response. FAU - Magon, Wojciech AU - Magon W AUID- ORCID: 0000-0002-7253-3397 AD - Department of Cardiac and Vascular Diseases, John Paul II Hospital in Krakow, 31-202 Krakow, Poland. AD - Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland. AD - Center for Innovative Medical Education, Department of Medical Education, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland. FAU - Stepniewski, Jakub AU - Stepniewski J AD - Department of Cardiac and Vascular Diseases, John Paul II Hospital in Krakow, 31-202 Krakow, Poland. AD - Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland. AD - Center for Innovative Medical Education, Department of Medical Education, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland. FAU - Waligora, Marcin AU - Waligora M AUID- ORCID: 0000-0002-0672-6369 AD - Department of Cardiac and Vascular Diseases, John Paul II Hospital in Krakow, 31-202 Krakow, Poland. AD - Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland. AD - Center for Innovative Medical Education, Department of Medical Education, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland. FAU - Jonas, Kamil AU - Jonas K AUID- ORCID: 0000-0003-2053-1370 AD - Department of Cardiac and Vascular Diseases, John Paul II Hospital in Krakow, 31-202 Krakow, Poland. AD - Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland. AD - Center for Innovative Medical Education, Department of Medical Education, Faculty of Medicine, Jagiellonian University Medical College, 30-688 Krakow, Poland. FAU - Przybylski, Roman AU - Przybylski R AD - Institute of Heart Diseases, Department of Cardiac Surgery and HeartTransplantation, Wroclaw Medical University, 50-367 Wroclaw, Poland. FAU - Podolec, Piotr AU - Podolec P AD - Department of Cardiac and Vascular Diseases, John Paul II Hospital in Krakow, 31-202 Krakow, Poland. AD - Department of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, 31-202 Krakow, Poland. FAU - Kopec, Grzegorz AU - Kopec G AUID- ORCID: 0000-0001-9921-2801 AD - Department of Cardiac and Vascular Diseases, John Paul II Hospital in Krakow, 31-202 Krakow, Poland. AD - Pulmonary Circulation Centre, Department of Cardiac and Vascular Diseases, Faculty of Medicine, Jagiellonian University Medical College, 31-008 Krakow, Poland. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220429 PL - Switzerland TA - Cells JT - Cells JID - 101600052 RN - 0 (Biomarkers) RN - 0 (Interleukin-6) RN - 0 (Interleukin-8) RN - 130068-27-8 (Interleukin-10) RN - 9007-41-4 (C-Reactive Protein) SB - IM MH - *Angioplasty, Balloon/adverse effects MH - Biomarkers MH - C-Reactive Protein MH - Humans MH - *Hypertension, Pulmonary/therapy MH - Inflammation MH - Interleukin-10 MH - Interleukin-6 MH - Interleukin-8 MH - Pulmonary Artery MH - *Pulmonary Embolism/complications/therapy PMC - PMC9102042 OTO - NOTNLM OT - biomarker OT - chronic thromboembolic pulmonary hypertension OT - endothelial function OT - endothelin 1 OT - interleukin 6 OT - interleukin 8 COIS- The authors declare no conflict of interest. EDAT- 2022/05/15 06:00 MHDA- 2022/05/18 06:00 PMCR- 2022/04/29 CRDT- 2022/05/14 01:08 PHST- 2022/01/20 00:00 [received] PHST- 2022/03/28 00:00 [revised] PHST- 2022/04/19 00:00 [accepted] PHST- 2022/05/14 01:08 [entrez] PHST- 2022/05/15 06:00 [pubmed] PHST- 2022/05/18 06:00 [medline] PHST- 2022/04/29 00:00 [pmc-release] AID - cells11091491 [pii] AID - cells-11-01491 [pii] AID - 10.3390/cells11091491 [doi] PST - epublish SO - Cells. 2022 Apr 29;11(9):1491. doi: 10.3390/cells11091491.