PMID- 3556459
OWN - NLM
STAT- MEDLINE
DCOM- 19870512
LR  - 20190721
IS  - 0014-4819 (Print)
IS  - 0014-4819 (Linking)
VI  - 65
IP  - 2
DP  - 1987
TI  - Limbic oxytocin and arginine 8-vasopressin in morphine tolerance and dependence.
PG  - 307-11
AB  - Immunoreactive oxytocin (OXT) and arginine8-vasopressin (AVP) levels were 
      measured in limbic areas of the mouse brain (hippocampus, amygdala and basal 
      forebrain). Peptides were measured by radioimmunoassay (RIA). Acute morphine 
      treatment caused a naloxone-reversible increase in OXT content in all three brain 
      regions. The AVP contents of the same brain areas, on the other hand, were not 
      affected by acute morphine treatment. In mice rendered tolerant to/dependent on 
      morphine with subcutaneous morphine pellets, the OXT levels in the limbic brain 
      structures were in the control range (basal forebrain and amygdala) or even 
      decreased (hippocampus). In the latter brain structure of the tolerant animals, 
      the AVP content was also decreased. Naloxone-precipitated withdrawal syndrome in 
      the tolerant/dependent animals resulted in abrupt increases in the OXT and AVP 
      levels of the hippocampus and in the OXT content of the basal forebrain 
      structures.
FAU - Kovacs, G L
AU  - Kovacs GL
FAU - Laczi, F
AU  - Laczi F
FAU - Vecsernyes, M
AU  - Vecsernyes M
FAU - Hodi, K
AU  - Hodi K
FAU - Telegdy, G
AU  - Telegdy G
FAU - Laszlo, F A
AU  - Laszlo FA
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Exp Brain Res
JT  - Experimental brain research
JID - 0043312
RN  - 0 (Peptide Fragments)
RN  - 113-79-1 (Arginine Vasopressin)
RN  - 36B82AMQ7N (Naloxone)
RN  - 50-56-6 (Oxytocin)
RN  - 76I7G6D29C (Morphine)
RN  - 87619-87-2 (argipressin (4-9))
SB  - IM
MH  - Amygdala/drug effects/metabolism
MH  - Animals
MH  - Arginine Vasopressin/*metabolism
MH  - Drug Tolerance
MH  - Hippocampus/drug effects/metabolism
MH  - Limbic System/drug effects/*metabolism
MH  - Male
MH  - Mice
MH  - Mice, Inbred Strains
MH  - Morphine/*metabolism
MH  - Morphine Dependence/*metabolism
MH  - Naloxone/pharmacology
MH  - Oxytocin/*metabolism
MH  - Peptide Fragments/*metabolism
MH  - Radioimmunoassay
EDAT- 1987/01/01 00:00
MHDA- 1987/01/01 00:01
CRDT- 1987/01/01 00:00
PHST- 1987/01/01 00:00 [pubmed]
PHST- 1987/01/01 00:01 [medline]
PHST- 1987/01/01 00:00 [entrez]
AID - 10.1007/BF00236302 [doi]
PST - ppublish
SO  - Exp Brain Res. 1987;65(2):307-11. doi: 10.1007/BF00236302.