PMID- 35565653
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220716
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Apr 19
TI  - Dried Plum's Polyphenolic Compounds and Carbohydrates Contribute to Its 
      Osteoprotective Effects and Exhibit Prebiotic Activity in Estrogen Deficient 
      C57BL/6 Mice.
LID - 10.3390/nu14091685 [doi]
LID - 1685
AB  - Evidence of dried plum's benefits on bone continues to emerge. This study 
      investigated the contribution of the fruit's polyphenol (PP) and carbohydrate 
      (CHO) components on a bone model of postmenopausal osteoporosis to explore their 
      prebiotic activity. Osteopenic ovariectomized mice were fed diets supplemented 
      with dried plum, a crude extract of dried plum's polyphenolic compounds, or the 
      PP or CHO fraction of the crude extract. The effects of treatments on the bone 
      phenotype were assessed at 5 and 10 weeks as well as the prebiotic activity of 
      the different components of dried plum. Both the CHO and PP fractions of the 
      extract contributed to the effects on bone with the CHO suppressing bone 
      formation and resorption, and the PP temporally down-regulating formation. The PP 
      and CHO components also altered the gut microbiota and cecal short chain fatty 
      acids. These findings demonstrate that the CHO as well as the PP components of 
      dried plum have potential prebiotic activity, but they have differential roles in 
      mediating the alterations in bone formation and resorption that protect bone in 
      estrogen deficiency.
FAU - Smith, Brenda J
AU  - Smith BJ
AUID- ORCID: 0000-0002-7296-8534
AD  - Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 
      74078, USA.
FAU - Hatter, Bethany
AU  - Hatter B
AD  - Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 
      74078, USA.
FAU - Washburn, Karley
AU  - Washburn K
AD  - Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 
      74078, USA.
FAU - Graef-Downard, Jennifer
AU  - Graef-Downard J
AD  - Department of Nutritional Sciences, University of Oklahoma Health Sciences 
      Center, Oklahoma City, OK 73117, USA.
FAU - Ojo, Babajide A
AU  - Ojo BA
AUID- ORCID: 0000-0003-3100-6635
AD  - Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 
      74078, USA.
FAU - El-Rassi, Guadalupe Davila
AU  - El-Rassi GD
AD  - Department of Food and Animal Sciences, Oklahoma State University, Stillwater, OK 
      74078, USA.
FAU - Cichewicz, Robert H
AU  - Cichewicz RH
AD  - Department of Chemistry and Biochemistry, University of Oklahoma, Norman, OK 
      73019, USA.
FAU - Payton, Mark
AU  - Payton M
AD  - Department of Biomedical Sciences, Rocky Vista University, Parker, CO 80134, USA.
FAU - Lucas, Edralin A
AU  - Lucas EA
AD  - Department of Nutritional Sciences, Oklahoma State University, Stillwater, OK 
      74078, USA.
LA  - eng
GR  - HR-14-126/Oklahoma Center for the Advancement of Science and Technology/
PT  - Journal Article
DEP - 20220419
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Complex Mixtures)
RN  - 0 (Estrogens)
RN  - 0 (Polyphenols)
RN  - 0 (Prebiotics)
SB  - IM
MH  - Animals
MH  - Bone Density
MH  - Complex Mixtures/pharmacology
MH  - Estrogens/pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - *Polyphenols/pharmacology
MH  - Prebiotics
MH  - *Prunus domestica
PMC - PMC9102795
OTO - NOTNLM
OT  - bone
OT  - dried plum
OT  - gut-bone axis
OT  - menopause
OT  - osteoporosis
OT  - polyphenols
OT  - short chain fatty acids
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript, or in the decision to publish the results.
EDAT- 2022/05/15 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/04/19
CRDT- 2022/05/14 01:20
PHST- 2022/03/21 00:00 [received]
PHST- 2022/04/13 00:00 [revised]
PHST- 2022/04/15 00:00 [accepted]
PHST- 2022/05/14 01:20 [entrez]
PHST- 2022/05/15 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/04/19 00:00 [pmc-release]
AID - nu14091685 [pii]
AID - nutrients-14-01685 [pii]
AID - 10.3390/nu14091685 [doi]
PST - epublish
SO  - Nutrients. 2022 Apr 19;14(9):1685. doi: 10.3390/nu14091685.