PMID- 35565691
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220716
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Apr 21
TI  - Omega-3 Fatty Acids and Their Interaction with the Gut Microbiome in the 
      Prevention and Amelioration of Type-2 Diabetes.
LID - 10.3390/nu14091723 [doi]
LID - 1723
AB  - Type-2 diabetes mellitus (T2DM) is often linked with hyperglycemia, disturbed 
      lipid profiles, inflammation, and gut dysbiosis. Omega-3 fatty acid 
      supplementation has a vital role in the management of T2DM. As a result, a better 
      understanding of the potential role of omega-3 fatty acids in the development and 
      progression of T2DM by influencing the intestinal microflora will help to improve 
      the therapeutic intervention for T2DM and related complications. Focusing on the 
      molecular mechanisms and signaling pathways induced by omega-3 fatty acids, this 
      paper attempts to comprehensively review and discuss the putative associations 
      between omega-3 fatty acids, gut dysbiosis, and the pathophysiology of T2DM and 
      its related comorbidities. In addition, we contemplate the importance of gut 
      microbiota in T2DM prevention and treatment and ponder the role of omega-3 fatty 
      acids in T2DM by positively modulating gut microbiota, which may lead to 
      discovery of novel targets and therapeutic strategies thereby paving way for 
      further comprehensive, mechanistic, and clinical studies.
FAU - Kumar, Manoj
AU  - Kumar M
AUID- ORCID: 0000-0002-2040-8631
AD  - National Institute for Research in Environmental Health, Bhopal 462030, India.
FAU - Pal, Namrata
AU  - Pal N
AD  - National Institute for Research in Environmental Health, Bhopal 462030, India.
FAU - Sharma, Poonam
AU  - Sharma P
AD  - National Institute for Research in Environmental Health, Bhopal 462030, India.
FAU - Kumawat, Manoj
AU  - Kumawat M
AUID- ORCID: 0000-0001-6088-4133
AD  - National Institute for Research in Environmental Health, Bhopal 462030, India.
FAU - Sarma, Devojit Kumar
AU  - Sarma DK
AUID- ORCID: 0000-0002-2749-4114
AD  - National Institute for Research in Environmental Health, Bhopal 462030, India.
FAU - Nabi, Bilkees
AU  - Nabi B
AD  - Department of Biochemistry and Biochemical Engineering, Sam Higginbottom 
      University of Agriculture, Technology and Sciences, Allahabad 211007, India.
FAU - Verma, Vinod
AU  - Verma V
AD  - Stem Cell Research Centre, Department of Hematology, Sanjay Gandhi Post-Graduate 
      Institute of Medical Sciences, Lucknow 226014, India.
FAU - Tiwari, Rajnarayan R
AU  - Tiwari RR
AUID- ORCID: 0000-0002-4676-9603
AD  - National Institute for Research in Environmental Health, Bhopal 462030, India.
FAU - Shubham, Swasti
AU  - Shubham S
AD  - National Institute for Research in Environmental Health, Bhopal 462030, India.
FAU - Arjmandi, Bahram
AU  - Arjmandi B
AUID- ORCID: 0000-0003-1358-0238
AD  - Department of Nutrition and Integrative Physiology, Florida State University, 
      Tallahassee, FL 32302, USA.
FAU - Nagpal, Ravinder
AU  - Nagpal R
AUID- ORCID: 0000-0002-4250-1749
AD  - Department of Nutrition and Integrative Physiology, Florida State University, 
      Tallahassee, FL 32302, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20220421
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - *Diabetes Mellitus, Type 2/drug therapy/metabolism/prevention & control
MH  - Dysbiosis/prevention & control
MH  - *Fatty Acids, Omega-3/pharmacology/therapeutic use
MH  - *Gastrointestinal Microbiome/physiology
MH  - Humans
MH  - *Hyperglycemia/drug therapy
PMC - PMC9104474
OTO - NOTNLM
OT  - alpha-linolenic acid
OT  - diabetes mellitus
OT  - docosahexaenoic acid
OT  - eicosapentaenoic acid
OT  - gut
OT  - microbiota
OT  - omega-3 fatty acids
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/15 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/04/21
CRDT- 2022/05/14 01:20
PHST- 2022/03/31 00:00 [received]
PHST- 2022/04/16 00:00 [revised]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/05/14 01:20 [entrez]
PHST- 2022/05/15 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/04/21 00:00 [pmc-release]
AID - nu14091723 [pii]
AID - nutrients-14-01723 [pii]
AID - 10.3390/nu14091723 [doi]
PST - epublish
SO  - Nutrients. 2022 Apr 21;14(9):1723. doi: 10.3390/nu14091723.