PMID- 35565728
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220716
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Apr 22
TI  - Vitamin D and Chronic Diseases among First-Generation Immigrants: A Large-Scale 
      Study Using Canadian Health Measures Survey (CHMS) Data.
LID - 10.3390/nu14091760 [doi]
LID - 1760
AB  - Background: Nearly 22% of the Canadian population are first-generation 
      immigrants. We investigated immigrants' health status and health deterioration 
      over time in terms of the prevalence of chronic diseases (CDs) and their 
      relationship to vitD status. Methods: We used cycles three (2012-2013) and four 
      (2014-2015) of the Canadian Health Measures Survey. These data contained unique 
      health information and direct physical/blood measures, including serum 
      25-hydroxyvitamin D (S-25(OH)D). Indicators of health status and deterioration 
      were the prevalence of CDs diagnosed by healthcare professionals, self-reported 
      general and mental health, and CD-related biomarkers. Results: The data (n = 
      11,579) included immigrants from more than 153 countries. Immigrants were 
      healthier than non-immigrants for most health status measures. The prevalence of 
      CDs was higher among those who migrated to Canada aged >/= 18 years. A longer time 
      in Canada after immigration was associated with a higher risk for CDs. The mean 
      S-25(OH)D was lower among immigrants, higher among patients with CDs, and 
      inversely associated with glycated hemoglobin, total cholesterol/high-density 
      lipoprotein ratio, immunoglobulin E, serum ferritin, and blood hemoglobin. After 
      adjusting for covariates, no association was found between S-25(OH)D and the 
      prevalence of CDs. Conclusions: Lower levels of accumulated S-25(OH)D among 
      immigrants may impact their health profile in terms of CD-related biomarkers, 
      which partially explains immigrants' health deterioration over time. We recommend 
      further longitudinal research to investigate immigrants' vitD and health 
      deterioration.
FAU - Yousef, Said
AU  - Yousef S
AD  - Faculty of Medicine, School of Epidemiology and Public Health, University of 
      Ottawa, Ottawa, ON K1G 5Z3, Canada.
AD  - Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, 
      Ottawa, ON K1Y 4W7, Canada.
FAU - Colman, Ian
AU  - Colman I
AD  - Faculty of Medicine, School of Epidemiology and Public Health, University of 
      Ottawa, Ottawa, ON K1G 5Z3, Canada.
FAU - Papadimitropoulos, Manny
AU  - Papadimitropoulos M
AD  - Eli Lilly Canada Inc., Toronto, ON M5X 1B1, Canada.
AD  - Faculty of Pharmacy, University of Toronto, Toronto, ON M5S 3M2, Canada.
FAU - Manuel, Douglas
AU  - Manuel D
AD  - Ottawa Hospital Research Institute, Ottawa, ON K1Y 4E9, Canada.
AD  - Institute for Clinical Evaluative Sciences, Ottawa, ON K1Y 4E9, Canada.
AD  - Department of Family Medicine, University of Ottawa, Ottawa, ON K1H 8M5, Canada.
FAU - Hossain, Alomgir
AU  - Hossain A
AUID- ORCID: 0000-0002-7614-0072
AD  - Faculty of Medicine, School of Epidemiology and Public Health, University of 
      Ottawa, Ottawa, ON K1G 5Z3, Canada.
AD  - Institute for Clinical Evaluative Sciences, Ottawa, ON K1Y 4E9, Canada.
FAU - Faris, MoezAlIslam
AU  - Faris M
AUID- ORCID: 0000-0002-7970-2616
AD  - Department of Clinical Nutrition and Dietetics, Research Institute of Medical and 
      Health Sciences (RIMHS), College of Health Sciences, University of Sharjah, 
      Sharjah 27272, United Arab Emirates.
FAU - Wells, George A
AU  - Wells GA
AD  - Faculty of Medicine, School of Epidemiology and Public Health, University of 
      Ottawa, Ottawa, ON K1G 5Z3, Canada.
AD  - Cardiovascular Research Methods Centre, University of Ottawa Heart Institute, 
      Ottawa, ON K1Y 4W7, Canada.
LA  - eng
PT  - Journal Article
DEP - 20220422
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Biomarkers)
RN  - 0 (CHM protein, human)
RN  - 0 (Vitamins)
RN  - 1406-16-2 (Vitamin D)
SB  - IM
MH  - Adaptor Proteins, Signal Transducing
MH  - Biomarkers
MH  - Canada/epidemiology
MH  - Chronic Disease
MH  - *Emigrants and Immigrants
MH  - Humans
MH  - *Vitamin D
MH  - Vitamins
PMC - PMC9099619
OTO - NOTNLM
OT  - chronic diseases
OT  - immigrants' health deterioration
OT  - serum 25-hydroxyvitamin D
OT  - vitamin D
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/15 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/04/22
CRDT- 2022/05/14 01:21
PHST- 2022/03/16 00:00 [received]
PHST- 2022/04/13 00:00 [revised]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/05/14 01:21 [entrez]
PHST- 2022/05/15 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/04/22 00:00 [pmc-release]
AID - nu14091760 [pii]
AID - nutrients-14-01760 [pii]
AID - 10.3390/nu14091760 [doi]
PST - epublish
SO  - Nutrients. 2022 Apr 22;14(9):1760. doi: 10.3390/nu14091760.