PMID- 35565733
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20230308
IS  - 2072-6643 (Electronic)
IS  - 2072-6643 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Apr 23
TI  - Consumption of Vegetables Is Associated with Systemic Inflammation in Older 
      Adults.
LID - 10.3390/nu14091765 [doi]
LID - 1765
AB  - It is hypothesized that healthy diets rich in fruits and vegetables (FV) can 
      modulate the inflammatory status in older adults. However, to determine the 
      actual impact of FV on inflammatory status, adiposity level and objectively 
      assessed physical activity (PA) behaviors need to be considered. The aim of the 
      present study was to explore associations between FV intake and biomarkers of 
      systemic inflammation in older adults. Based on a sample of 233 older adults 
      (65-70 years old), the following inflammatory biomarkers were assessed: 
      C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), IL-10, IL-18, and 
      monocyte chemoattractant protein-1 (MCP-1). FV intake was assessed by 
      self-report, and PA behaviors encompassing time spent sedentary and in 
      moderate-to-vigorous PA (MVPA) were determined using accelerometers. Associations 
      between FV intake and inflammatory biomarkers were analyzed using stepwise linear 
      regression models while adjusting for several covariates, including 
      health-related food groups, adherence to the MVPA guidelines, total sedentary 
      time, and waist circumference. While no significant associations were observed 
      for the total FV intake, the vegetable intake was inversely associated with 
      levels of IL6 (beta = -0.15; p < 0.05). In contrast, fruit intake was not associated 
      with any inflammatory biomarker. In conclusion, our findings indicate beneficial 
      associations between vegetable intake and levels of a pro-inflammatory biomarker 
      in older adults, which strengthens public health efforts to promote 
      vegetable-rich diets in older adults to mitigate age-related systemic 
      inflammation.
FAU - Papaioannou, Konstantinos-Georgios
AU  - Papaioannou KG
AUID- ORCID: 0000-0002-4041-2355
AD  - School of Health Sciences, Orebro University, 70182 Orebro, Sweden.
FAU - Kadi, Fawzi
AU  - Kadi F
AUID- ORCID: 0000-0002-9831-0896
AD  - School of Health Sciences, Orebro University, 70182 Orebro, Sweden.
FAU - Nilsson, Andreas
AU  - Nilsson A
AUID- ORCID: 0000-0003-3793-335X
AD  - School of Health Sciences, Orebro University, 70182 Orebro, Sweden.
LA  - eng
GR  - 727565/EU HORIZON 2020 Research and Innovation Programme/
GR  - 20210070/Familjen Kamprads stiftelse/
PT  - Journal Article
DEP - 20220423
PL  - Switzerland
TA  - Nutrients
JT  - Nutrients
JID - 101521595
RN  - 0 (Biomarkers)
SB  - IM
MH  - Aged
MH  - Biomarkers
MH  - Diet
MH  - *Fruit
MH  - Humans
MH  - Inflammation
MH  - *Vegetables
PMC - PMC9105870
OTO - NOTNLM
OT  - abdominal obesity
OT  - aging
OT  - dietary habits
OT  - inflammatory biomarkers
OT  - nutrition
OT  - physical activity
OT  - sedentary time
COIS- The authors declare no conflict of interest. The funders had no role in the 
      design of the study; in the collection, analyses, or interpretation of data; in 
      the writing of the manuscript; or in the decision to publish the results.
EDAT- 2022/05/15 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/04/23
CRDT- 2022/05/14 01:21
PHST- 2022/04/08 00:00 [received]
PHST- 2022/04/21 00:00 [revised]
PHST- 2022/04/22 00:00 [accepted]
PHST- 2022/05/14 01:21 [entrez]
PHST- 2022/05/15 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/04/23 00:00 [pmc-release]
AID - nu14091765 [pii]
AID - nutrients-14-01765 [pii]
AID - 10.3390/nu14091765 [doi]
PST - epublish
SO  - Nutrients. 2022 Apr 23;14(9):1765. doi: 10.3390/nu14091765.