PMID- 35566102
OWN - NLM
STAT- MEDLINE
DCOM- 20220519
LR  - 20231213
IS  - 1420-3049 (Electronic)
IS  - 1420-3049 (Linking)
VI  - 27
IP  - 9
DP  - 2022 Apr 25
TI  - Extract from Black Soybean Cultivar A63 Extract Ameliorates Atopic 
      Dermatitis-like Skin Inflammation in an Oxazolone-Induced Murine Model.
LID - 10.3390/molecules27092751 [doi]
LID - 2751
AB  - Black soybean has been used in traditional medicine to treat inflammatory 
      diseases, cancer, and diabetes and as a nutritional source since ancient times. 
      We found that Korean black soybean cultivar A63 has more cyanidin-3-O-glucoside, 
      (C3G), procyanidin B2 (PB2), and epicatechin (EPC) contents than other cultivars 
      and has beneficial effects on cell viability and anti-oxidation. Given the higher 
      concentration of anthocyanidins and their strong anti-oxidant activity, we 
      predicted that A63 extract could relieve inflammatory disease symptoms, including 
      those of atopic dermatitis (AD). Here, we evaluated the anti-AD activity of A63 
      extract in an oxazolone (OXA)-induced mouse model. A63 extract treatment 
      significantly reduced epidermal thickness and inflammatory cell infiltration, 
      downregulated the expression of AD gene markers, including Interleukin (IL)-4 and 
      IL-5, and restored damaged skin barrier tissues. Furthermore, A63 extract 
      influenced the activation of the signal transducer and activator of transcription 
      (STAT) 3 and STAT6, extracellular regulatory kinase (ERK), and c-Jun N-terminal 
      kinase (JNK) signaling pathways, which play a crucial role in the development of 
      AD. Altogether, our results suggest that A63 can ameliorate AD-like skin 
      inflammation by inhibiting inflammatory cytokine production and STAT3/6 and 
      Mitogen-activated protein kinase (MAPK) signaling and restoring skin barrier 
      function.
FAU - Dorjsembe, Banzragch
AU  - Dorjsembe B
AD  - Smart Farm Research Center, Korea Institute of Science and Technology (KIST), 
      Gangneung 25451, Korea.
AD  - Division of Bio-Medical Science and Technology, KIST School, Korea University of 
      Science and Technology (UST), Daejeon 34113, Korea.
FAU - Nho, Chu Won
AU  - Nho CW
AUID- ORCID: 0000-0002-7805-0521
AD  - Smart Farm Research Center, Korea Institute of Science and Technology (KIST), 
      Gangneung 25451, Korea.
FAU - Choi, Yongsoo
AU  - Choi Y
AD  - Natural Product Research Center, Korea Institute of Science and Technology 
      (KIST), Gangneung 25451, Korea.
FAU - Kim, Jin-Chul
AU  - Kim JC
AUID- ORCID: 0000-0002-2535-2761
AD  - Natural Product Research Center, Korea Institute of Science and Technology 
      (KIST), Gangneung 25451, Korea.
LA  - eng
GR  - 2E31881/Korea Institute of Science and Technology/
GR  - PJ013335/Republic of Korea, the Rural Development Administration under 
      Cooperative Research Program for Agriculture Science & Technology 
      Development/
PT  - Journal Article
DEP - 20220425
PL  - Switzerland
TA  - Molecules
JT  - Molecules (Basel, Switzerland)
JID - 100964009
RN  - 0 (Cytokines)
RN  - 0 (Plant Extracts)
RN  - 15646-46-5 (Oxazolone)
SB  - IM
MH  - Animals
MH  - Cytokines/metabolism
MH  - *Dermatitis, Atopic/chemically induced/drug therapy/metabolism
MH  - Disease Models, Animal
MH  - Inflammation/chemically induced/drug therapy/metabolism
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Oxazolone/adverse effects
MH  - Plant Extracts/metabolism
MH  - Skin
MH  - Glycine max/metabolism
PMC - PMC9104407
OTO - NOTNLM
OT  - Glycine max L.
OT  - HS human dermal fibroblast cells (HS68)
OT  - atopic dermatitis
OT  - black soybean A63
COIS- The authors confirm that article content has no conflict of interest.
EDAT- 2022/05/15 06:00
MHDA- 2022/05/20 06:00
PMCR- 2022/04/25
CRDT- 2022/05/14 01:23
PHST- 2022/03/23 00:00 [received]
PHST- 2022/04/14 00:00 [revised]
PHST- 2022/04/22 00:00 [accepted]
PHST- 2022/05/14 01:23 [entrez]
PHST- 2022/05/15 06:00 [pubmed]
PHST- 2022/05/20 06:00 [medline]
PHST- 2022/04/25 00:00 [pmc-release]
AID - molecules27092751 [pii]
AID - molecules-27-02751 [pii]
AID - 10.3390/molecules27092751 [doi]
PST - epublish
SO  - Molecules. 2022 Apr 25;27(9):2751. doi: 10.3390/molecules27092751.