PMID- 35566332 OWN - NLM STAT- MEDLINE DCOM- 20220519 LR - 20220716 IS - 1420-3049 (Electronic) IS - 1420-3049 (Linking) VI - 27 IP - 9 DP - 2022 May 6 TI - Multi-Element Analysis and Origin Discrimination of Panax notoginseng Based on Inductively Coupled Plasma Tandem Mass Spectrometry (ICP-MS/MS). LID - 10.3390/molecules27092982 [doi] LID - 2982 AB - Panax notoginseng is an important functional health product, and has been used worldwide because of a wide range of pharmacological activities, of which the taproot is the main edible or medicinal part. However, the technologies for origin discrimination still need to be further studied. In this study, an ICP-MS/MS method for the accurate determination of 49 elements was established, whereby the instrumental detection limits (LODs) were between 0.0003 and 7.716 mg/kg, whereas the quantification limits (LOQs) were between 0.0011 and 25.7202 mg/kg, recovery of the method was in the range of 85.82% to 104.98%, and the relative standard deviations (RSDs) were lower than 10%. Based on the content of multi-element in P. notoginseng (total of 89 mixed samples), the discriminant models of origins and cultivation models were accurately determined by the neural networks (prediction accuracy was 0.9259 and area under ROC curve was 0.9750) and the support vector machine algorithm (both 1.0000), respectively. The discriminant models established in this study could be used to support transparency and traceability of supply chains of P. notoginseng and thus avoid the fraud of geographic identification. FAU - Ji, Chao AU - Ji C AD - State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, National Engineering Research Center for Applied Technology of Agricultural Biodiversity, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China. FAU - Liu, Jinyu AU - Liu J AD - State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, National Engineering Research Center for Applied Technology of Agricultural Biodiversity, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China. FAU - Zhang, Qin AU - Zhang Q AD - Laboratory for Quality Control and Traceability of Food and Agricultural Products, Tianjin Normal University, Tianjin 300387, China. FAU - Li, Juan AU - Li J AD - Laboratory for Quality Control and Traceability of Food and Agricultural Products, Tianjin Normal University, Tianjin 300387, China. FAU - Wu, Zhiqiang AU - Wu Z AD - Laboratory for Quality Control and Traceability of Food and Agricultural Products, Tianjin Normal University, Tianjin 300387, China. FAU - Wang, Xingyu AU - Wang X AD - Laboratory for Quality Control and Traceability of Food and Agricultural Products, Tianjin Normal University, Tianjin 300387, China. FAU - Xie, Yuxin AU - Xie Y AD - Laboratory for Quality Control and Traceability of Food and Agricultural Products, Tianjin Normal University, Tianjin 300387, China. FAU - Zhao, Jiangchao AU - Zhao J AUID- ORCID: 0000-0002-2894-8560 AD - Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, AR 72701, USA. FAU - Shi, Rui AU - Shi R AUID- ORCID: 0000-0003-2593-7302 AD - Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Landscape Architecture Engineering Research Center of National Forestry and Grassland Administration, Southwest Forestry University, Kunming 650224, China. FAU - Ma, Xing AU - Ma X AD - The Animal, Plant & Foodstuff Inspection Center, Tianjin Customs, Tianjin 300387, China. FAU - Khan, Mohammad Rizwan AU - Khan MR AUID- ORCID: 0000-0001-6270-8539 AD - Department of Chemistry, College of Science, King Saud University, Riyadh 11451, Saudi Arabia. FAU - Busquets, Rosa AU - Busquets R AUID- ORCID: 0000-0001-9033-4757 AD - School of Life Sciences, Pharmacy and Chemistry, Kingston University London, Penrhyn Road, Kingston upon Thames KT1 2EE, UK. FAU - He, Xiahong AU - He X AUID- ORCID: 0000-0002-8702-2135 AD - State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, National Engineering Research Center for Applied Technology of Agricultural Biodiversity, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China. AD - Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Landscape Architecture Engineering Research Center of National Forestry and Grassland Administration, Southwest Forestry University, Kunming 650224, China. FAU - Zhu, Youyong AU - Zhu Y AD - State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, National Engineering Research Center for Applied Technology of Agricultural Biodiversity, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China. FAU - Zhu, Shusheng AU - Zhu S AD - State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, National Engineering Research Center for Applied Technology of Agricultural Biodiversity, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China. FAU - Zheng, Wenjie AU - Zheng W AD - State Key Laboratory for Conservation and Utilization of Bio-Resources in Yunnan, National Engineering Research Center for Applied Technology of Agricultural Biodiversity, College of Plant Protection, Yunnan Agricultural University, Kunming 650201, China. AD - Laboratory for Quality Control and Traceability of Food and Agricultural Products, Tianjin Normal University, Tianjin 300387, China. AD - Key Laboratory for Forest Resources Conservation and Utilization in the Southwest Mountains of China, Ministry of Education, Southwest Landscape Architecture Engineering Research Center of National Forestry and Grassland Administration, Southwest Forestry University, Kunming 650224, China. LA - eng GR - 202102AE090042, 202102AA310048-2 and 2019ZG00901/Major Science and Technology Project of Yunnan and Kunming/ GR - 2021JH002/Major Science and Technology Project of Kunming/ GR - 202105AE160016/Innovative Research Team of Science and Technology in Yunnan Province/ GR - 046180201 and 135305YJ01/Tianjin Normal University/ GR - CARS-21/China Agriculture Research System/ GR - RSP-2021/138/the Researchers Supporting Project Number/ PT - Journal Article DEP - 20220506 PL - Switzerland TA - Molecules JT - Molecules (Basel, Switzerland) JID - 100964009 SB - IM MH - *Panax notoginseng/chemistry MH - Spectrum Analysis MH - Tandem Mass Spectrometry PMC - PMC9105934 OTO - NOTNLM OT - ICP-MS/MS OT - Panax notoginseng OT - cultivation model discrimination OT - multi-element OT - origin discrimination COIS- The authors declare that they have no known competing financial interest or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/05/15 06:00 MHDA- 2022/05/20 06:00 PMCR- 2022/05/06 CRDT- 2022/05/14 01:24 PHST- 2022/04/11 00:00 [received] PHST- 2022/04/29 00:00 [revised] PHST- 2022/05/03 00:00 [accepted] PHST- 2022/05/14 01:24 [entrez] PHST- 2022/05/15 06:00 [pubmed] PHST- 2022/05/20 06:00 [medline] PHST- 2022/05/06 00:00 [pmc-release] AID - molecules27092982 [pii] AID - molecules-27-02982 [pii] AID - 10.3390/molecules27092982 [doi] PST - epublish SO - Molecules. 2022 May 6;27(9):2982. doi: 10.3390/molecules27092982.