PMID- 35566406
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20230308
IS  - 2077-0383 (Print)
IS  - 2077-0383 (Electronic)
IS  - 2077-0383 (Linking)
VI  - 11
IP  - 9
DP  - 2022 Apr 19
TI  - Short-Term Mortality in Patients with Heart Failure at the End-of-Life Stages: 
      Hades Study.
LID - 10.3390/jcm11092280 [doi]
LID - 2280
AB  - Background: Information regarding short-term vital prognosis in patients with 
      heart failure at advanced stages of the disease is scarce. Objective: To develop 
      a three-month mortality predictive model for patients with advanced heart 
      failure. Methods: Prospective observational study carried out in primary care and 
      a convalescence community facility. Heart failure patients either New York Heart 
      Association (NYHA) III with at least two HF hospitalizations during the previous 
      six months or NYHA IV with/without previous recent hospitalization were included 
      in the study. Multivariable predictive models using Cox regression were 
      performed. Results: Of 271 patients included, 55 (20.3%) died during the first 
      three months of follow-up. Mean age was 84.2 years (SD 8.3) and 59.8% were women. 
      Predictive model including NT-proBNP had a C-index of 0.78 (95% CI 0.71; 0.85) 
      and identified male gender, low body mass index, high potassium and NT-proBNP 
      levels, and moderate-to-severe dependence for daily living activities (Barthel 
      index < 40) as risk factors of mortality. In the model without NT-proBNP, C index 
      was 0.72 (95% CI 0.64; 0.79) and, in addition to gender, body mass index, low 
      Barthel index, and severe reductions in glomerular filtration rate showed the 
      highest predictive hazard ratios for short-term mortality. Conclusions: In 
      addition to age, male gender, potassium levels, low body mass index, and low 
      glomerular filtration, dependence for activities of daily living add strong power 
      to predict mortality at three months in patients with advanced heart failure.
FAU - Munoz, Miguel Angel
AU  - Munoz MA
AUID- ORCID: 0000-0002-4083-3248
AD  - Gerencia Territorial de Barcelona (Primary Healthcare), Institut Catala de la 
      Salut, 08007 Barcelona, Spain.
AD  - Departament de Ciencies Experimentals i de la Salut, School of Medicine, 
      Universitat Pompeu Fabra, 08002 Barcelona, Spain.
AD  - Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi 
      Gol), 08007 Barcelona, Spain.
FAU - Calero, Esther
AU  - Calero E
AD  - Bellvitge University Hospital, Institut Catala de la Salut, 08921 Barcelona, 
      Spain.
FAU - Duran, Julio
AU  - Duran J
AD  - Clinica Sant Antoni (Institut Medic i de Rehabilitacio), 08038 Barcelona, Spain.
FAU - Navas, Elena
AU  - Navas E
AD  - Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi 
      Gol), 08007 Barcelona, Spain.
FAU - Alonso, Susana
AU  - Alonso S
AD  - Gerencia Territorial de Barcelona (Primary Healthcare), Institut Catala de la 
      Salut, 08007 Barcelona, Spain.
FAU - Argemi, Nuria
AU  - Argemi N
AD  - Gerencia Territorial de Barcelona (Primary Healthcare), Institut Catala de la 
      Salut, 08007 Barcelona, Spain.
FAU - Casademunt, Marta
AU  - Casademunt M
AD  - Gerencia Territorial de Barcelona (Primary Healthcare), Institut Catala de la 
      Salut, 08007 Barcelona, Spain.
FAU - Furio, Patricia
AU  - Furio P
AD  - Gerencia Territorial de Barcelona (Primary Healthcare), Institut Catala de la 
      Salut, 08007 Barcelona, Spain.
FAU - Casajuana, Elena
AU  - Casajuana E
AD  - Gerencia Territorial de Barcelona (Primary Healthcare), Institut Catala de la 
      Salut, 08007 Barcelona, Spain.
FAU - Torralba, Nuria
AU  - Torralba N
AD  - Gerencia Territorial de Barcelona (Primary Healthcare), Institut Catala de la 
      Salut, 08007 Barcelona, Spain.
FAU - Farre, Nuria
AU  - Farre N
AUID- ORCID: 0000-0003-3110-6572
AD  - Hospital del Mar Medical Research Institute, 08003 Barcelona, Spain.
FAU - Abellana, Rosa
AU  - Abellana R
AD  - Departament de Fonaments Clinics-Bioestadistica, School of Medicine, Universitat 
      de Barcelona, 08007 Barcelona, Spain.
FAU - Verdu-Rotellar, Jose-Maria
AU  - Verdu-Rotellar JM
AD  - Gerencia Territorial de Barcelona (Primary Healthcare), Institut Catala de la 
      Salut, 08007 Barcelona, Spain.
AD  - Departament de Ciencies Experimentals i de la Salut, School of Medicine, 
      Universitat Pompeu Fabra, 08002 Barcelona, Spain.
AD  - Institut Universitari d'Investigacio en Atencio Primaria Jordi Gol (IDIAP Jordi 
      Gol), 08007 Barcelona, Spain.
FAU - On Behalf Of Hades Study
AU  - On Behalf Of Hades Study
LA  - eng
GR  - SLT002/16/00073/Departament de Salut/
PT  - Journal Article
DEP - 20220419
PL  - Switzerland
TA  - J Clin Med
JT  - Journal of clinical medicine
JID - 101606588
PMC - PMC9101156
OTO - NOTNLM
OT  - community setting
OT  - end of life
OT  - heart failure
OT  - mortality
OT  - predictive model
OT  - prognostic
OT  - short term prognosis
COIS- The authors declare that they have no competing interest.
EDAT- 2022/05/15 06:00
MHDA- 2022/05/15 06:01
PMCR- 2022/04/19
CRDT- 2022/05/14 01:25
PHST- 2022/03/18 00:00 [received]
PHST- 2022/04/12 00:00 [revised]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/05/14 01:25 [entrez]
PHST- 2022/05/15 06:00 [pubmed]
PHST- 2022/05/15 06:01 [medline]
PHST- 2022/04/19 00:00 [pmc-release]
AID - jcm11092280 [pii]
AID - jcm-11-02280 [pii]
AID - 10.3390/jcm11092280 [doi]
PST - epublish
SO  - J Clin Med. 2022 Apr 19;11(9):2280. doi: 10.3390/jcm11092280.