PMID- 35566848
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220516
IS  - 2073-4360 (Electronic)
IS  - 2073-4360 (Linking)
VI  - 14
IP  - 9
DP  - 2022 Apr 20
TI  - Association Behavior of Amphiphilic ABA Triblock Copolymer Composed of 
      Poly(2-methoxyethyl acrylate) (A) and Poly(ethylene oxide) (B) in Aqueous 
      Solution.
LID - 10.3390/polym14091678 [doi]
LID - 1678
AB  - Poly(2-methoxyethyl acrylate) (PMEA) and poly(ethylene oxide) (PEO) have 
      protein-antifouling properties and blood compatibility. ABA triblock copolymers 
      (PMEA(l)-PEO(11340)-PMEA(m) (MEOM(n); n is average value of l and m)) were 
      prepared using single-electron transfer-living radical polymerization (SET-LRP) 
      using a bifunctional PEO macroinitiator. Two types of MEOM(n) composed of PMEA 
      blocks with degrees of polymerization (DP = n) of 85 and 777 were prepared using 
      the same PEO macroinitiator. MEOM(n) formed flower micelles with a hydrophobic 
      PMEA (A) core and hydrophilic PEO (B) loop shells in diluted water with a similar 
      appearance to petals. The hydrodynamic radii of MEOM(85) and MEOM(777) were 151 
      and 108 nm, respectively. The PMEA block with a large DP formed a tightly packed 
      core. The aggregation number (N(agg)) of the PMEA block in a single flower 
      micelle for MEOM(85) and MEOM(777) was 156 and 164, respectively, which were 
      estimated using a light scattering technique. The critical micelle concentrations 
      (CMCs) for MEOM(85) and MEOM(777) were 0.01 and 0.002 g/L, respectively, as 
      determined by the light scattering intensity and fluorescence probe techniques. 
      The size, N(agg), and CMC for MEOM(85) and MEOM(777) were almost the same 
      independent of hydrophobic DP of the PMEA block.
FAU - Mizoue, Yoko
AU  - Mizoue Y
AD  - Department of Applied Chemistry, Graduate School of Engineering, University of 
      Hyogo, 2167 Shosha, Himeji 671-2280, Hyogo, Japan.
FAU - Onodera, Ema
AU  - Onodera E
AD  - Department of Applied Chemistry, Graduate School of Engineering, University of 
      Hyogo, 2167 Shosha, Himeji 671-2280, Hyogo, Japan.
FAU - Haraguchi, Kazutoshi
AU  - Haraguchi K
AD  - Department of Applied Molecular Chemistry, College of Industrial Technology, 
      Nihon University, 1-2-1 Izumicho, Narashino 275-8575, Chiba, Japan.
FAU - Yusa, Shin-Ichi
AU  - Yusa SI
AUID- ORCID: 0000-0002-2838-5200
AD  - Department of Applied Chemistry, Graduate School of Engineering, University of 
      Hyogo, 2167 Shosha, Himeji 671-2280, Hyogo, Japan.
LA  - eng
GR  - 21H02005, 21K19931, 21H05027, 21H05535, JPJSBP120203509/Japan Society for the 
      Promotion of Science/
GR  - 20214044/Ministry of Education, Culture, Sports, Science and Technology/
PT  - Journal Article
DEP - 20220420
PL  - Switzerland
TA  - Polymers (Basel)
JT  - Polymers
JID - 101545357
PMC - PMC9105209
OTO - NOTNLM
OT  - amphiphilic copolymer
OT  - flower-like micelle
OT  - poly(ethylene oxide)
OT  - single-electron transfer-living radical polymerization
OT  - triblock copolymer
COIS- The authors declare no conflict of interest.
EDAT- 2022/05/15 06:00
MHDA- 2022/05/15 06:01
PMCR- 2022/04/20
CRDT- 2022/05/14 01:27
PHST- 2022/03/17 00:00 [received]
PHST- 2022/04/15 00:00 [revised]
PHST- 2022/04/18 00:00 [accepted]
PHST- 2022/05/14 01:27 [entrez]
PHST- 2022/05/15 06:00 [pubmed]
PHST- 2022/05/15 06:01 [medline]
PHST- 2022/04/20 00:00 [pmc-release]
AID - polym14091678 [pii]
AID - polymers-14-01678 [pii]
AID - 10.3390/polym14091678 [doi]
PST - epublish
SO  - Polymers (Basel). 2022 Apr 20;14(9):1678. doi: 10.3390/polym14091678.