PMID- 35567107 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20230916 IS - 2223-7747 (Print) IS - 2223-7747 (Electronic) IS - 2223-7747 (Linking) VI - 11 IP - 9 DP - 2022 Apr 19 TI - Advancement and New Trends in Analysis of Pesticide Residues in Food: A Comprehensive Review. LID - 10.3390/plants11091106 [doi] LID - 1106 AB - Food safety is a rising challenge worldwide due to the expanding population and the need to produce food to feed the growing population. At the same time, pesticide residues found in high concentrations in fresh agriculture pose a significant threat to food safety. Presently, crop output is being increased by applying herbicides, fungicides, insecticides, pesticides, fertilizers, nematicides, and soil amendments. A combination of factors, including bioaccumulation, widespread usage, selective toxicity, and stability, make pesticides among the most toxic compounds polluting the environment. They are especially harmful in vegetables and fruits because people are exposed to them. Thus, it is critical to monitor pesticide levels in fruits and vegetables using all analytical techniques available. Any evaluation of the condition of pesticide contamination in fruits and vegetables necessitates knowledge of maximum residue levels (MRLs). We set out the problems in determining various types of pesticides in vegetables and fruits, including the complexity and the diversity of matrices in biological materials. This review examines the different analytical techniques to determine the target analytes that must be isolated before final consumption. Many processes involved determining pesticide residues in fruits and vegetables and their advantages and disadvantages have been discussed with recommendations. Furthermore, MRLs of target pesticide residues in fruit and vegetable samples are discussed in the context of data from the literature. The review also examines MRLs' impact on the international trade of fruits and vegetables. Accurate, sensitive, and robust analytical procedures are critical to ensuring that pesticide levels in food products are effectively regulated. Despite advances in detection technology, effective sample preparation procedures for pesticide residue measurement in cereals and feedstuffs are still needed. In addition, these methods must be compatible with current analytical techniques. Multi-residue approaches that cover a wide range of pesticides are desired, even though pesticides' diverse natures, classes, and physio-chemical characteristics make such methods challenging to assemble. This review will be valuable to food analysts and regulatory authorities to monitor the quality and safety of fresh food products. FAU - Wahab, Shadma AU - Wahab S AUID- ORCID: 0000-0001-9941-2918 AD - Department of Pharmacognosy, College of Pharmacy, King Khalid University, Abha 61421, Saudi Arabia. FAU - Muzammil, Khursheed AU - Muzammil K AUID- ORCID: 0000-0003-1676-8092 AD - Department of Public Health, College of Applied Medical Sciences, Khamis Mushait, King Khalid University, Abha 61412, Saudi Arabia. FAU - Nasir, Nazim AU - Nasir N AD - Department of Basic Medical Sciences, College of Applied Medical Sciences, Khamis Mushait, King Khalid University, Abha 61412, Saudi Arabia. FAU - Khan, Mohammad Suhail AU - Khan MS AD - Department of Public Health, College of Applied Medical Sciences, Khamis Mushait, King Khalid University, Abha 61412, Saudi Arabia. FAU - Ahmad, Md Faruque AU - Ahmad MF AD - Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia. FAU - Khalid, Mohammad AU - Khalid M AD - Department of Pharmacognosy, College of Pharmacy, Prince Sattam Bin Abdulaziz University, P.O. Box 173, Al-Kharj 11942, Saudi Arabia. FAU - Ahmad, Wasim AU - Ahmad W AUID- ORCID: 0000-0003-2639-9200 AD - Department of Pharmacy, Mohammed Al-Mana College for Medical Sciences, Safaa, Dammam 34222, Saudi Arabia. FAU - Dawria, Adam AU - Dawria A AD - Department of Public Health, College of Health Sciences, Khamis Mushait Campus, King Khalid University, Abha 61412, Saudi Arabia. FAU - Reddy, Lingala Kalyan Viswanath AU - Reddy LKV AD - Department of Public Health, College of Health Sciences, Saudi Electronic University, Abha 61412, Saudi Arabia. FAU - Busayli, Abdulrahman Mohammed AU - Busayli AM AD - Department of Clinical Nutrition, College of Applied Medical Sciences, Jazan University, Jazan 45142, Saudi Arabia. LA - eng GR - RGP.1/336/42./King Khalid University/ PT - Journal Article PT - Review DEP - 20220419 PL - Switzerland TA - Plants (Basel) JT - Plants (Basel, Switzerland) JID - 101596181 PMC - PMC9105315 OTO - NOTNLM OT - QuEChERS OT - analytical techniques OT - chromatographic OT - food OT - maximum residue limits OT - pesticides OT - toxicity COIS- The authors confirm that this article content has no conflict of interest. EDAT- 2022/05/15 06:00 MHDA- 2022/05/15 06:01 PMCR- 2022/04/19 CRDT- 2022/05/14 01:29 PHST- 2022/03/07 00:00 [received] PHST- 2022/04/05 00:00 [revised] PHST- 2022/04/16 00:00 [accepted] PHST- 2022/05/14 01:29 [entrez] PHST- 2022/05/15 06:00 [pubmed] PHST- 2022/05/15 06:01 [medline] PHST- 2022/04/19 00:00 [pmc-release] AID - plants11091106 [pii] AID - plants-11-01106 [pii] AID - 10.3390/plants11091106 [doi] PST - epublish SO - Plants (Basel). 2022 Apr 19;11(9):1106. doi: 10.3390/plants11091106.