PMID- 35569932 OWN - NLM STAT- MEDLINE DCOM- 20230127 LR - 20230202 IS - 1349-533X (Electronic) IS - 1341-0725 (Linking) VI - 65 IP - 1 DP - 2023 Jan 25 TI - [Allergy and immunotoxicology in preventive and clinical medicine from theory to practice: Occupational allergy and isocyanate-induced asthma]. PG - 1-8 LID - 10.1539/sangyoeisei.2021-040-A [doi] AB - Genetic and environmental factors and their interactions cause diseases and deteriorate health (Genetic and Environmental Interaction). Exposure to environmental factors plays a major role in the deterioration of health in the workplace.Occupational asthma (OA) is a common disorder in the workplace. Approaches to OA are well described and discussed in "Japanese Guideline for Diagnosis and Management of Occupational Allergic Diseases" by the Japanese Society of Occupational and Environmental Allergy. According to the guideline, OA and work-aggravated asthma comprise work-related asthma, and OA can be further divided into two disease entities: sensitizer-induced OA and irritant-induced OA. The guidelines also describe diagnostic and therapeutic strategies for OA. Since a definitive diagnosis of OA requires a comprehensive decision based on a detailed interview on clinical symptoms related to employment status and clinical tests, including inhalation tests of suspected substances as needed, the possibility of OA should be considered as the first step toward diagnosis of the patient. Otherwise, OA may not be diagnosed. Therapeutic strategies include exposure avoidance, environmental arrangements in the workplace, utilization of social resources for workers, and conventional pharmacotherapy for asthma.Artificially synthesized small compounds are used in various industries and can cause allergies. For example, isocyanates are small compounds in the -NCO group, which have been toxicologically studied. It was later shown that isocyanate could cause various nontoxic adverse health effects, including allergic reactions. Since small agents with low molecular weights bind to proteins, detecting their specific immunoglobulin E (IgE) antibodies targeting small compounds is generally difficult. In contrast, isocyanate-specific IgE antibodies are detectable in individuals with isocyanate allergies.Suspecting OA is essential in cases exposed to newly synthesized compounds, or to those that are already known but applied to new uses, which can be better understood and predicted by studying the health effects of isocyanates.Academic interest in various issues related to allergies, immunology, and toxicology in the workplace includes clinical medicine, epidemiology, and epigenetics related to environmental exposure. Further advanced research in these areas is necessary and promising. CN - Research Group for Allergy and Immunotoxicology, Japan Society for Occupational Health (JSOH) FAU - Dobashi, Kunio AU - Dobashi K AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Writing Team, The Committee for AIT, JSOH. AD - Jobu Hospital for Respiratory Diseases, Gunma. FAU - Yoshida, Takahiko AU - Yoshida T AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Writing Team, The Committee for AIT, JSOH. AD - Asahikawa Medical University. FAU - Morimoto, Yasuo AU - Morimoto Y AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Writing Team, The Committee for AIT, JSOH. AD - University of Occupational and Environmental Health, Japan. Institute of Industrial Ecological Sciences. FAU - Ueda, Atsuhi AU - Ueda A AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Writing Team, The Committee for AIT, JSOH. AD - NPO Asian Health Promotion Network Center. FAU - Itoh, Toshihiro AU - Itoh T AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Writing Team, The Committee for AIT, JSOH. AD - Asahikawa Medical University. FAU - Wada, Hiroo AU - Wada H AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Writing Team, The Committee for AIT, JSOH. AD - Juntendo University Graduate School of Medicine. FAU - Kayama, Fujio AU - Kayama F AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Jichi Medical University. FAU - Satoh, Kazuhiro AU - Satoh K AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - University of Fukui. FAU - Satoh, Minoru AU - Satoh M AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - University of Occupational and Environmental Health, Japan. FAU - Shibata, Eiji AU - Shibata E AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Yokkaichi Nursing and Medical Care University. FAU - Suganuma, Narufumi AU - Suganuma N AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Kochi Medical School. FAU - Takeshita, Tatsuya AU - Takeshita T AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Wakayama Medical University. FAU - Tsunoda, Masashi AU - Tsunoda M AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - National Defense Medical College. FAU - Nishimura, Yasumitsu AU - Nishimura Y AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Kawasaki Medical School. FAU - Yanagisawa, Hiroyuki AU - Yanagisawa H AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - The Jikei University School of Medicine. FAU - Li, Qing AU - Li Q AD - The Committee Members for Allergy and Immunotoxicology (AIT), Japan Society for Occupational Health (JSOH). AD - Nippon Medical School. LA - jpn PT - English Abstract PT - Journal Article DEP - 20220513 PL - Japan TA - Sangyo Eiseigaku Zasshi JT - Sangyo eiseigaku zasshi = Journal of occupational health JID - 9507473 RN - 0 (Isocyanates) RN - 37341-29-0 (Immunoglobulin E) SB - IM MH - Humans MH - *Occupational Exposure/adverse effects/prevention & control MH - *Asthma, Occupational/chemically induced/diagnosis/prevention & control MH - *Occupational Diseases/chemically induced/diagnosis/prevention & control MH - Isocyanates/adverse effects MH - Immunoglobulin E/adverse effects MH - *Clinical Medicine EDAT- 2022/05/16 06:00 MHDA- 2023/01/28 06:00 CRDT- 2022/05/15 21:53 PHST- 2022/05/16 06:00 [pubmed] PHST- 2023/01/28 06:00 [medline] PHST- 2022/05/15 21:53 [entrez] AID - 10.1539/sangyoeisei.2021-040-A [doi] PST - ppublish SO - Sangyo Eiseigaku Zasshi. 2023 Jan 25;65(1):1-8. doi: 10.1539/sangyoeisei.2021-040-A. Epub 2022 May 13.