PMID- 35570198 OWN - NLM STAT- MEDLINE DCOM- 20221011 LR - 20221222 IS - 1879-0844 (Electronic) IS - 1388-9842 (Linking) VI - 24 IP - 9 DP - 2022 Sep TI - Factors associated with health-related quality of life in heart failure in 23 000 patients from 40 countries: results of the G-CHF research programme. PG - 1478-1490 LID - 10.1002/ejhf.2535 [doi] AB - AIMS: To examine clinical and social correlates of health-related quality of life (HRQL) in patients with heart failure (HF) from high- (HIC), upper middle- (UMIC), lower middle- (LMIC) and low-income (LIC) countries. METHODS AND RESULTS: Between 2017 and 2020, 23 292 patients with HF (32% inpatients, 61% men) from 40 countries were enrolled in the Global Congestive Heart Failure study. HRQL was recorded at baseline using the Kansas City Cardiomyopathy Questionnaire (KCCQ)-12. In a cross-sectional analysis, we compared age- and sex-adjusted mean KCCQ-12 summary scores (SS: 0-100, higher = better) between patients from different country income levels. We used multivariable linear regression examining correlations (estimated coefficients) of KCCQ-12-SS with sociodemographic, comorbidity, treatment and symptom covariates. The adjusted model (37 covariates) was informed by univariable findings, clinical importance and backward selection. Mean age was 63 years and 40% of patients were in New York Heart Association (NYHA) class III-IV. Average HRQL was 55 SD 27. It was 62.5 (95% confidence interval [CI] 62.0-63.1) in HIC, 56.8 (56.1-57.4) in UMIC, 48.6 (48.0-49.3) in LMIC, and 38.5 (37.3-39.7) in LICs (p < 0.0001). Strong correlates (estimated coefficient [95% CI]) of KCCQ-12-SS were NYHA class III versus class I/II (-12.1 [-12.8 to -11.4] and class IV versus class I/II (-16.5 [-17.7 to -15.3]), effort dyspnoea (-9.5 [-10.2 to -8.8]) and living in LIC versus HIC (-5.8 [-7.1 to -4.4]). Symptoms explained most of the KCCQ-12-SS variability (partial R(2) = 0.32 of total adjusted R(2) = 0.51), followed by sociodemographic factors (R(2) = 0.12). Results were consistent in populations across income levels. CONCLUSION: The most important correlates of HRQL in HF patients relate to HF symptom severity, irrespective of country income level. CI - (c) 2022 European Society of Cardiology. FAU - Johansson, Isabelle AU - Johansson I AUID- ORCID: 0000-0002-4577-0530 AD - Population Health Research Institute, McMaster University, Hamilton, Canada. AD - Department of Health Research Methods, Evidence, and Impact, McMaster University Faculty of Health Sciences, Hamilton, Canada. FAU - Balasubramanian, Kumar AU - Balasubramanian K AD - Population Health Research Institute, McMaster University, Hamilton, Canada. FAU - Bangdiwala, Shrikant AU - Bangdiwala S AD - Population Health Research Institute, McMaster University, Hamilton, Canada. AD - Department of Health Research Methods, Evidence, and Impact, McMaster University Faculty of Health Sciences, Hamilton, Canada. FAU - Mielniczuk, Lisa AU - Mielniczuk L AD - Division of Cardiology, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. FAU - Hage, Camilla AU - Hage C AD - Karolinska University Hospital Heart, Vascular and Neuro Theme Heart Failure Section, Stockholm, Sweden. AD - Karolinska Institutet Department of Medicine Cardiology Unit, Stockholm, Sweden. FAU - Sharma, Sanjib Kumar AU - Sharma SK AD - B.P. Koirala Institute of Health Sciences, Dharan, Nepal. FAU - Branch, Kelley AU - Branch K AD - Division of Cardiology, University of Washington School of Medicine, Seattle, WA, USA. FAU - Zhu, Jun AU - Zhu J AD - Fuwai Hospital, CAMS & PUMC, Beijing, China. FAU - Kragholm, Kristian AU - Kragholm K AD - Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark. FAU - Sliwa, Karen AU - Sliwa K AD - Cape Heart Institute, Department of Medicine and Cardiology, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa. FAU - Alla, Francois AU - Alla F AD - Bordeaux Population Health Research Center, Inserm, Universite de Bordeaux, Bordeaux, France. AD - Prevention Department, CHU, Bordeaux, France. FAU - Yonga, Gerald AU - Yonga G AD - School of Medicine, University of Nairobi, Nairobi, Kenya. FAU - Roy, Ambuj AU - Roy A AD - Department of Cardiology, All India Institute of Medical Sciences, New Delhi, India. FAU - Orlandini, Andres AU - Orlandini A AD - ECLA (Estudios Clinicos Latino America), Rosario, Argentina. FAU - Grinvalds, Alex AU - Grinvalds A AD - Population Health Research Institute, McMaster University, Hamilton, Canada. FAU - McCready, Tara AU - McCready T AD - Population Health Research Institute, McMaster University, Hamilton, Canada. FAU - Pogosova, Nana AU - Pogosova N AD - National Medical Research Center of Cardiology, Moscow, Russia. FAU - Stork, Stefan AU - Stork S AD - Comprehensive Heart Failure Center, University and University Hospital Wurzburg, Wurzburg, Germany. FAU - McMurray, John J V AU - McMurray JJV AD - BHF Cardiovascular Research Centre, University of Glasgow, Scotland, UK. FAU - Conen, David AU - Conen D AD - Population Health Research Institute, McMaster University, Hamilton, Canada. AD - Department of Health Research Methods, Evidence, and Impact, McMaster University Faculty of Health Sciences, Hamilton, Canada. FAU - Yusuf, Salim AU - Yusuf S AD - Population Health Research Institute, McMaster University, Hamilton, Canada. AD - Department of Health Research Methods, Evidence, and Impact, McMaster University Faculty of Health Sciences, Hamilton, Canada. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't DEP - 20220615 PL - England TA - Eur J Heart Fail JT - European journal of heart failure JID - 100887595 SB - IM CIN - Eur J Heart Fail. 2022 Sep;24(9):1491-1492. PMID: 35781911 MH - Comorbidity MH - Cross-Sectional Studies MH - Female MH - Health Status MH - *Heart Failure/drug therapy MH - Humans MH - Male MH - Middle Aged MH - *Quality of Life MH - Surveys and Questionnaires OTO - NOTNLM OT - Correlates OT - Global OT - Health status OT - Heart failure OT - Quality of life EDAT- 2022/05/16 06:00 MHDA- 2022/10/12 06:00 CRDT- 2022/05/15 22:52 PHST- 2022/05/05 00:00 [revised] PHST- 2021/12/19 00:00 [received] PHST- 2022/05/07 00:00 [accepted] PHST- 2022/05/16 06:00 [pubmed] PHST- 2022/10/12 06:00 [medline] PHST- 2022/05/15 22:52 [entrez] AID - 10.1002/ejhf.2535 [doi] PST - ppublish SO - Eur J Heart Fail. 2022 Sep;24(9):1478-1490. doi: 10.1002/ejhf.2535. Epub 2022 Jun 15.