PMID- 35571618
OWN - NLM
STAT- MEDLINE
DCOM- 20220517
LR  - 20220519
IS  - 1875-8630 (Electronic)
IS  - 0278-0240 (Print)
IS  - 0278-0240 (Linking)
VI  - 2022
DP  - 2022
TI  - Abnormal Proteomics Profile of Plasma Reveals the Immunological Pathogenesis of 
      Severe Aplastic Anemia.
PG  - 3700691
LID - 10.1155/2022/3700691 [doi]
LID - 3700691
AB  - Severe aplastic anemia (SAA) is an immune-mediated bone marrow failure 
      characterized by pancytopenia. This study was aimed at uncovering proteins of 
      plasma that were differentially expressed in SAA patients. 8 SAA patients and 8 
      health controls were enrolled and detected by data independent acquisition (DIA) 
      technology. 154 differential expression proteins (DEPs) in plasma of SAA patients 
      were identified. GO and KEGG analyses indicated DEPs were mainly involved in the 
      immune system process. Specifically, C-C motif chemokine 18 (CCL18), matrix 
      metalloproteinase-3 (MMP3), histidine-rich glycoprotein (HRG), and 
      lactotransferrin (lactoferrin (Lf)) may play an important role in the immune 
      pathogenesis of SAA. CCL18, MMP3, HRG, and Lf might be potential biomarkers for 
      SAA.
CI  - Copyright (c) 2022 Weiwei Qi et al.
FAU - Qi, Weiwei
AU  - Qi W
AD  - Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan 
      Street, Heping District, Tianjin 300052, China.
FAU - Zhang, Yu
AU  - Zhang Y
AD  - Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan 
      Street, Heping District, Tianjin 300052, China.
FAU - Yang, Wenhao
AU  - Yang W
AD  - Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan 
      Street, Heping District, Tianjin 300052, China.
FAU - Liu, Chunyan
AU  - Liu C
AD  - Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan 
      Street, Heping District, Tianjin 300052, China.
FAU - Wang, Huaquan
AU  - Wang H
AD  - Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan 
      Street, Heping District, Tianjin 300052, China.
FAU - Fu, Rong
AU  - Fu R
AUID- ORCID: 0000-0002-9928-9224
AD  - Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan 
      Street, Heping District, Tianjin 300052, China.
FAU - Shao, Zonghong
AU  - Shao Z
AUID- ORCID: 0000-0003-4966-2956
AD  - Department of Hematology, Tianjin Medical University General Hospital, 154 Anshan 
      Street, Heping District, Tianjin 300052, China.
LA  - eng
PT  - Journal Article
DEP - 20220506
PL  - United States
TA  - Dis Markers
JT  - Disease markers
JID - 8604127
RN  - EC 3.4.24.17 (Matrix Metalloproteinase 3)
SB  - IM
MH  - *Anemia, Aplastic/genetics/metabolism
MH  - Humans
MH  - Matrix Metalloproteinase 3
MH  - Proteomics
PMC - PMC9106528
COIS- The authors have no conflict of interests to declare.
EDAT- 2022/05/17 06:00
MHDA- 2022/05/18 06:00
PMCR- 2022/05/06
CRDT- 2022/05/16 04:02
PHST- 2021/12/26 00:00 [received]
PHST- 2022/04/13 00:00 [accepted]
PHST- 2022/05/16 04:02 [entrez]
PHST- 2022/05/17 06:00 [pubmed]
PHST- 2022/05/18 06:00 [medline]
PHST- 2022/05/06 00:00 [pmc-release]
AID - 10.1155/2022/3700691 [doi]
PST - epublish
SO  - Dis Markers. 2022 May 6;2022:3700691. doi: 10.1155/2022/3700691. eCollection 
      2022.