PMID- 35571637
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220519
IS  - 2219-6803 (Electronic)
IS  - 2218-676X (Print)
IS  - 2218-676X (Linking)
VI  - 11
IP  - 4
DP  - 2022 Apr
TI  - A EWSR1-CREM-rearranged gastric mesenchymal tumor accompanied by gastritis 
      cystica profunda and with probable benign behavior: a case report.
PG  - 959-966
LID - 10.21037/tcr-21-2331 [doi]
AB  - Genomic rearrangements involving EWSR1 and the CREB family of transcription 
      factors are increasingly detected in an array of mesenchymal neoplasms, most of 
      which are malignant. Gastritis cystica profunda (GCP) is a rare disease 
      characterized by cystic dilatation of gastric glands into the submucosa and 
      generally regarded as a precursor to tumor. Herein, we report a peculiar case in 
      which an EWSR1-CREM-rearranged gastric mesenchymal tumor was admixed with GCP in 
      a 64-year-old woman. All layers of the gastric wall were invaded, although no 
      lymph node or neural invasion, or tumoral vascular emboli was noted. The mass 
      showed readily distinguishable epithelial and mesenchymal components. The 
      epithelial component consisted mainly of glandular structures with some showing 
      metaplastic growth. The epithelial cells showed focally atypical hyperchromatic 
      nuclei, slightly eosinophilic cytoplasm, and infrequent mitosis. The mesenchymal 
      component consisted of monomorphic, ovoid-shaped cells with scanty cytoplasm, 
      regular nuclei, and rare mitotic figures. Immunohistochemically, the epithelial 
      cells were uniformly positive for cytokeratins, and the mesenchymal neoplasm 
      showed focal positivity for CD10, CD117 and CD56. An EWSR1-CREM fusion was 
      identified with genomic profiling and confirmed with fluorescence in situ 
      hybridization (FISH) in the tumor. Given the low mitotic activity, absence of 
      nodal or distant spread and vascular or neural invasion, and disease-free status 
      at 28-month follow-up, both lesions were likely benign. To our knowledge, this is 
      the first to report an EWSR1-CREM fusion in a gastric mesenchymal tumor with 
      accompanying GCP.
CI  - 2022 Translational Cancer Research. All rights reserved.
FAU - Cui, Qian
AU  - Cui Q
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Wu, Hongmei
AU  - Wu H
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Chen, Yu
AU  - Chen Y
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Xiao, Zebin
AU  - Xiao Z
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Liu, Zhihua
AU  - Liu Z
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Chen, Jie
AU  - Chen J
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
FAU - Li, Zhi
AU  - Li Z
AD  - Department of Pathology, Guangdong Provincial People's Hospital, Guangdong 
      Academy of Medical Sciences, Guangzhou, China.
LA  - eng
PT  - Case Reports
PL  - China
TA  - Transl Cancer Res
JT  - Translational cancer research
JID - 101585958
PMC - PMC9091036
OTO - NOTNLM
OT  - EWSR1-CREM gene fusion
OT  - Gastric mesenchymal tumor
OT  - case report
OT  - gastritis cystica profunda (GCP)
OT  - next-generation sequencing
COIS- Conflicts of Interest: All authors have completed the ICMJE uniform disclosure 
      form (available at 
      https://tcr.amegroups.com/article/view/10.21037/tcr-21-2331/coif). The authors 
      have no conflicts of interest to declare.
EDAT- 2022/05/17 06:00
MHDA- 2022/05/17 06:01
PMCR- 2022/04/01
CRDT- 2022/05/16 04:02
PHST- 2021/10/23 00:00 [received]
PHST- 2022/01/27 00:00 [accepted]
PHST- 2022/05/16 04:02 [entrez]
PHST- 2022/05/17 06:00 [pubmed]
PHST- 2022/05/17 06:01 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - tcr-11-04-959 [pii]
AID - 10.21037/tcr-21-2331 [doi]
PST - ppublish
SO  - Transl Cancer Res. 2022 Apr;11(4):959-966. doi: 10.21037/tcr-21-2331.