PMID- 35571892
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2296-861X (Print)
IS  - 2296-861X (Electronic)
IS  - 2296-861X (Linking)
VI  - 9
DP  - 2022
TI  - Improvement in Mung Bean Peptide on High-Fat Diet-Induced Insulin Resistance Mice 
      Using Untargeted Serum Metabolomics.
PG  - 893270
LID - 10.3389/fnut.2022.893270 [doi]
LID - 893270
AB  - This study aimed to elucidate the potential regulatory mechanism of mung bean 
      peptides (MBPs) on glucolipid metabolism in insulin-resistant mice induced by 
      high-fat diet (HFD) using untargeted serum metabolomics, enzyme linked 
      immunosorbent assay (ELISA), intraperitoneal injection glucose tolerance test 
      (IPGTT), insulin tolerance test (IPITT), and hematoxylin-eosin staining (H&E). 
      The regulatory effect of MBPs for alleviating insulin resistance was studied by 
      measuring body weight, fasting blood glucose (FBG) and serum insulin levels, 
      C-Peptide levels, inflammatory and antioxidant factors, and histopathological 
      observation of C57BL/6 mice. The experimental results showed that dietary 
      intervention with MBPs (245 mg/kg/d) for 5 weeks significantly relieved insulin 
      resistance in HFD mice. The body weight, insulin resistance index, and the levels 
      of FBG, C-Peptide, IL-6, TNF-alpha, and MDA in the serum of HFD mice significantly 
      decreased (P < 0.05). Conversely, SOD content and pancreatic beta cell function 
      index significantly increased (P < 0.05), and the damaged pancreatic tissue was 
      repaired. One biomarker associated with insulin resistance was glycine. In 
      addition, there were four important differential metabolites: pyroglutamate, 
      D-glutamine, aminoadipic acid, and nicotinamide, involved in 12 metabolic pathway 
      changes. It was found that MBPs may regulate amino acid, glycerol phospholipid, 
      fatty acid, alkaloid, and nicotinamide metabolism to regulate the metabolic 
      profile of HFD mice in a beneficial direction.
CI  - Copyright (c) 2022 Li, Tian, Feng, Zhang, Jiang, Zhang, Zhan and Wang.
FAU - Li, Lina
AU  - Li L
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
AD  - Library, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Tian, Yu
AU  - Tian Y
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Feng, Yuchao
AU  - Feng Y
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Zhang, Shu
AU  - Zhang S
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Jiang, Yingjun
AU  - Jiang Y
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Zhang, Yiwei
AU  - Zhang Y
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Zhan, Yuanyuan
AU  - Zhan Y
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
FAU - Wang, Changyuan
AU  - Wang C
AD  - College of Food, Heilongjiang Bayi Agricultural University, Daqing, China.
LA  - eng
PT  - Journal Article
DEP - 20220429
PL  - Switzerland
TA  - Front Nutr
JT  - Frontiers in nutrition
JID - 101642264
PMC - PMC9101312
OTO - NOTNLM
OT  - glucolipid metabolism
OT  - insulin-resistant (IR)
OT  - mung bean peptides (MBPs)
OT  - obesity
OT  - untargeted serum metabolomics
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2022/05/17 06:00
MHDA- 2022/05/17 06:01
PMCR- 2022/01/01
CRDT- 2022/05/16 04:05
PHST- 2022/03/10 00:00 [received]
PHST- 2022/03/28 00:00 [accepted]
PHST- 2022/05/16 04:05 [entrez]
PHST- 2022/05/17 06:00 [pubmed]
PHST- 2022/05/17 06:01 [medline]
PHST- 2022/01/01 00:00 [pmc-release]
AID - 10.3389/fnut.2022.893270 [doi]
PST - epublish
SO  - Front Nutr. 2022 Apr 29;9:893270. doi: 10.3389/fnut.2022.893270. eCollection 
      2022.