PMID- 35572917
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 2213-0489 (Print)
IS  - 2213-0489 (Electronic)
IS  - 2213-0489 (Linking)
VI  - 17
DP  - 2022
TI  - Cytogenetically cryptic PML::RARA fusion in acute promyelocytic leukemia: Testing 
      strategies in the modern era.
PG  - 100320
LID - 10.1016/j.lrr.2022.100320 [doi]
LID - 100320
AB  - Acute promyelocytic leukemia (APL) is a unique leukemia that is characterized by 
      the PML::RARA fusion. This fusion is often detected by conventional karyotype and 
      fluorescence in situ hybridization (FISH); however, rare cases are cryptic and 
      require molecular techniques to identify the PML::RARA fusion. Furthermore, as 
      the incidence of these cases is rare, analysis by a targeted next-generation 
      sequencing (NGS) panel of myeloid associated genes has never been reported. 
      Herein, a clinical APL case is reported where the PML::RARA fusion was detected 
      only by reverse transcriptase-polymerase chain reaction (RT-PCR), thus 
      underscoring the necessity of utilizing complementary techniques when suspicion 
      for APL is present.
CI  - (c) 2022 The Authors. Published by Elsevier Ltd.
FAU - Karlin, Kirill
AU  - Karlin K
AD  - Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, United 
      States of America.
FAU - Bryke, Christine
AU  - Bryke C
AD  - Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, United 
      States of America.
FAU - Dias, Ajoy
AU  - Dias A
AD  - Department of Hematology-Oncology, Beth Israel Deaconess Medical Center, Boston, 
      MA, United States of America.
FAU - Michaels, Phillip
AU  - Michaels P
AD  - Department of Pathology, Beth Israel Deaconess Medical Center, Boston, MA, United 
      States of America.
LA  - eng
PT  - Case Reports
DEP - 20220504
PL  - England
TA  - Leuk Res Rep
JT  - Leukemia research reports
JID - 101608906
PMC - PMC9092513
OTO - NOTNLM
OT  - Acute promyelocytic leukemia
OT  - FISH
OT  - PML RARalpha
OT  - RT PCR
COIS- The authors have no competing interests.
EDAT- 2022/05/17 06:00
MHDA- 2022/05/17 06:01
PMCR- 2022/05/04
CRDT- 2022/05/16 04:20
PHST- 2022/02/11 00:00 [received]
PHST- 2022/04/27 00:00 [revised]
PHST- 2022/05/02 00:00 [accepted]
PHST- 2022/05/16 04:20 [entrez]
PHST- 2022/05/17 06:00 [pubmed]
PHST- 2022/05/17 06:01 [medline]
PHST- 2022/05/04 00:00 [pmc-release]
AID - S2213-0489(22)00032-2 [pii]
AID - 100320 [pii]
AID - 10.1016/j.lrr.2022.100320 [doi]
PST - epublish
SO  - Leuk Res Rep. 2022 May 4;17:100320. doi: 10.1016/j.lrr.2022.100320. eCollection 
      2022.