PMID- 35573153
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220716
IS  - 1598-2629 (Print)
IS  - 2092-6685 (Electronic)
IS  - 1598-2629 (Linking)
VI  - 22
IP  - 2
DP  - 2022 Apr
TI  - Obesity Exacerbates Coxsackievirus Infection via Lipid-Induced Mitochondrial 
      Reactive Oxygen Species Generation.
PG  - e19
LID - 10.4110/in.2022.22.e19 [doi]
LID - e19
AB  - Coxsackievirus B3 (CVB3) infection causes acute pancreatitis and myocarditis. 
      However, its pathophysiological mechanism is unclear. Here, we investigated how 
      lipid metabolism is associated with exacerbation of CVB3 pathology using high-fat 
      diet (HFD)-induced obese mice. Mice were intraperitoneally inoculated with 
      1x10(6) pfu/mouse of CVB3 after being fed a control or HFD to induce obesity. 
      Mice were treated with mitoquinone (MitoQ) to reduce the level of mitochondrial 
      ROS (mtROS). In obese mice, lipotoxicity of white adipose tissue-induced 
      inflammation caused increased replication of CVB3 and mortality. The 
      coxsackievirus adenovirus receptor increased under obese conditions, facilitating 
      CVB3 replication in vitro. However, lipid-treated cells with receptor-specific 
      inhibitors did not reduce CVB3 replication. In addition, lipid treatment 
      increased mitochondria-derived vesicle formation and the number of multivesicular 
      bodies. Alternatively, we found that inhibition of lipid-induced mtROS decreased 
      viral replication. Notably, HFD-fed mice were more susceptible to CVB3-induced 
      mortality in association with increased levels of CVB3 replication in adipose 
      tissue, which was ameliorated by administration of the mtROS inhibitor, MitoQ. 
      These results suggest that mtROS inhibitors can be used as potential treatments 
      for CVB3 infection.
CI  - Copyright (c) 2022. The Korean Association of Immunologists.
FAU - Kim, Seong-Ryeol
AU  - Kim SR
AD  - Department of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
FAU - Song, Jae-Hyoung
AU  - Song JH
AD  - Department of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
AD  - Kangwon Institute of Inclusive Technology, Kangwon National University, Chuncheon 
      24341, Korea.
FAU - Ahn, Jae-Hee
AU  - Ahn JH
AD  - Department of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
FAU - Jeong, Myeong Seon
AU  - Jeong MS
AD  - Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea.
FAU - Yang, Yoon Mee
AU  - Yang YM
AD  - Department of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
FAU - Cho, Jaewon
AU  - Cho J
AD  - Department of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
FAU - Jeong, Jae-Hyeon
AU  - Jeong JH
AD  - Department of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
FAU - Cha, Younggil
AU  - Cha Y
AD  - Department of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
FAU - Kim, Kil-Nam
AU  - Kim KN
AD  - Chuncheon Center, Korea Basic Science Institute (KBSI), Chuncheon 24341, Korea.
FAU - Kim, Hong Pyo
AU  - Kim HP
AD  - College of Pharmacy, Ajou University, Suwon 16499, Korea.
FAU - Chang, Sun-Young
AU  - Chang SY
AD  - College of Pharmacy, Ajou University, Suwon 16499, Korea.
FAU - Ko, Hyun-Jeong
AU  - Ko HJ
AUID- ORCID: 0000-0002-3844-928X
AD  - Department of Pharmacy, Kangwon National University, Chuncheon 24341, Korea.
LA  - eng
PT  - Journal Article
DEP - 20220411
PL  - Korea (South)
TA  - Immune Netw
JT  - Immune network
JID - 101137270
PMC - PMC9066006
OTO - NOTNLM
OT  - Coxsackievirus B3
OT  - Lipid metabolism
OT  - Mitochondria
OT  - Mitoquinone
OT  - Obesity
OT  - Reactive oxygen species
COIS- Conflict of interest: The authors declare no potential conflicts of interest.
EDAT- 2022/05/17 06:00
MHDA- 2022/05/17 06:01
PMCR- 2022/04/01
CRDT- 2022/05/16 04:24
PHST- 2021/11/01 00:00 [received]
PHST- 2022/03/16 00:00 [revised]
PHST- 2022/03/27 00:00 [accepted]
PHST- 2022/05/16 04:24 [entrez]
PHST- 2022/05/17 06:00 [pubmed]
PHST- 2022/05/17 06:01 [medline]
PHST- 2022/04/01 00:00 [pmc-release]
AID - 10.4110/in.2022.22.e19 [doi]
PST - epublish
SO  - Immune Netw. 2022 Apr 11;22(2):e19. doi: 10.4110/in.2022.22.e19. eCollection 2022 
      Apr.