PMID- 35573653 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220716 IS - 2352-9067 (Print) IS - 2352-9067 (Electronic) IS - 2352-9067 (Linking) VI - 40 DP - 2022 Jun TI - ECG differences and ECG predictors in patients presenting with ST segment elevation due to myocardial infarction versus takotsubo syndrome. PG - 101047 LID - 10.1016/j.ijcha.2022.101047 [doi] LID - 101047 AB - BACKGROUND: Previous studies comparing electrocardiogram (ECG) in Takotsubo syndrome (TS) versus ST elevation myocardial infarction (STEMI) included TS patients without ST elevation, did not consider the culprit lesion in STEMI or had groups that were unbalanced regarding sex and age. Accounting for these factors, we sought to conduct a more reliable comparison of ECG in TS with ST-elevation (STE-TS) versus STEMI. The secondary aim was to investigate if ST segment changes, T wave inversion or prolonged QT interval predicted ventricular arrhythmia or death in STE-TS and STEMI. METHODS: All STE-TS patients who presented at Sahlgrenska University Hospital between 2008 and 2019 were matched by sex and age to STEMI patients. STEMI patients were subcategorized according to whether or not the culprit lesion was located in the left anterior descending artery (LAD). Baseline characteristics, in-hospital outcomes and admission ECGs were analyzed. RESULTS: 104 STE-TS patients were sex- and age-matched with 274 STEMI patients (113 LAD-STEMI, 161 non-LAD STEMI). Admission ECG in STE-TS was more similar to LAD STEMI than non-LAD STEMI. Reciprocal ST depression was less common in STE-TS (7/104, 6.7%) compared with STEMI (112/274, 41%; p= < 0.001). The sum of all ST elevations and the sum of all ST-deviations predicted life-threatening ventricular arrhythmia (LTVA) or death in LAD STEMI but not in STE-TS. CONCLUSIONS: In conclusion, admission ECG in STE-TS was similar to LAD STEMI but reciprocal ST depression was less common in STE-TS compared with STEMI overall. ST segment changes predicted LTVA or death in STEMI but not in STE-TS. CI - (c) 2022 The Authors. FAU - Zeijlon, Rickard AU - Zeijlon R AD - Department of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden. AD - Department of Internal Medicine, Sahlgrenska University Hospital/S, Gothenburg, Sweden. AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. FAU - Chamat, Jasmina AU - Chamat J AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. AD - Department of Cardiology, Sahlgrenska University Hospital/O, Gothenburg, Sweden. FAU - Le, Vina AU - Le V AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. FAU - Wagerman, Johan AU - Wagerman J AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. FAU - Enabtawi, Israa AU - Enabtawi I AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. FAU - Jha, Sandeep AU - Jha S AD - Department of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden. AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. AD - Department of Internal Medicine, Kungalvs Hospital, Kungalv, Sweden. FAU - Mohammed, Mohammed Munir AU - Mohammed MM AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. AD - Department of Cardiology, Norra Alvsborgs Lanssjukhus, Trollhattan, Sweden. FAU - Shekka Espinosa, Aaron AU - Shekka Espinosa A AD - Department of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden. AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. FAU - Angeras, Oskar AU - Angeras O AD - Department of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden. AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. FAU - Ramunddal, Truls AU - Ramunddal T AD - Department of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden. AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. FAU - Omerovic, Elmir AU - Omerovic E AD - Department of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden. AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. FAU - Redfors, Bjorn AU - Redfors B AD - Department of Cardiology, Sahlgrenska University Hospital/S, Gothenburg, Sweden. AD - Wallenberg laboratory, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden. AD - Clinical Trial Center, Cardiovascular Research Foundation, NY, USA. AD - Department of Cardiology, New York-Presbyterian Hospital/Columbia University Medical Center, New York, USA. AD - Wallenberg Center for Molecular and Translational Medicine, University of Gothenburg, Gothenburg, Sweden. LA - eng PT - Journal Article DEP - 20220506 PL - Ireland TA - Int J Cardiol Heart Vasc JT - International journal of cardiology. Heart & vasculature JID - 101649525 PMC - PMC9096129 OTO - NOTNLM OT - Arrhythmia OT - ECG OT - ST-elevation myocardial infarction OT - Takotsubo syndrome COIS- The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2022/05/17 06:00 MHDA- 2022/05/17 06:01 PMCR- 2022/05/06 CRDT- 2022/05/16 04:30 PHST- 2022/03/22 00:00 [received] PHST- 2022/04/22 00:00 [revised] PHST- 2022/04/28 00:00 [accepted] PHST- 2022/05/16 04:30 [entrez] PHST- 2022/05/17 06:00 [pubmed] PHST- 2022/05/17 06:01 [medline] PHST- 2022/05/06 00:00 [pmc-release] AID - S2352-9067(22)00096-3 [pii] AID - 101047 [pii] AID - 10.1016/j.ijcha.2022.101047 [doi] PST - epublish SO - Int J Cardiol Heart Vasc. 2022 May 6;40:101047. doi: 10.1016/j.ijcha.2022.101047. eCollection 2022 Jun.