PMID- 35573945 OWN - NLM STAT- PubMed-not-MEDLINE LR - 20220519 IS - 2296-2360 (Print) IS - 2296-2360 (Electronic) IS - 2296-2360 (Linking) VI - 10 DP - 2022 TI - Periconceptional Folic Acid Supplementation and Newborn Birth Weights. PG - 844404 LID - 10.3389/fped.2022.844404 [doi] LID - 844404 AB - BACKGROUND: The relationship between maternal folic acid supplementation and the birth weights of offspring remains inconclusive. AIM: To examine the associations between maternal supplementation with folic acid only (FAO) or multiple micronutrients containing folic acid (MMFA) and newborn birth weights, as well as the risk of small for gestational week age (SGA) and large for gestational week age (LGA) newborns. METHODS: Data on 31,107 births from 2015 to 2018 were extracted from the population-based prenatal health care system in a district of Beijing. Generalized linear and logistic regression models were used to evaluate the association between maternal periconceptional folic acid supplementation and birth weights or with risk of small for gestational week age (SGA) and large for gestational week age (LGA). RESULTS: Compared with newborns whose mothers did not use any folic acid supplements, the newborns with maternal periconceptional folic acid supplementation had similar median birth weight but had a lower risk of SGA [adjusted odds ratio (aOR) = 0.81 (95% CI: 0.68-0.97)], however newborns born to mothers who took multiple micronutrients with folic acid (MMFA) with high compliance had a 25.59 g (95% CI: 6.49-44.69) higher median birth weight. Periconceptional women took folic acid only (FAO) (aOR = 0.83; 95%CI: 0.67-1.01) or MMFA (aOR = 0.74; 95%CI: 0.60-0.91) with high compliance decreased the risk of SGA, but has no impact on the risk of LGA. CONCLUSION: Periconceptional FAO supplementation has no impact on the median birth weight of offspring and the risk of LGA. Compared with FAO, MMFA supplementation may increase the average birth weight, and a high compliance of supplementation with FAO or MMFA may reduce the risk of SGA, with MMFA having ad stronger effect than FAO. CI - Copyright (c) 2022 Lin, Wang, Li, Zhang, Jin, Tong, Meng, Ren, Chen and Jin. FAU - Lin, Jing AU - Lin J AD - Department of Obstetrics and Gynecology, The Sixth Medical Center of People's Liberation Army (PLA) General Hospital, Beijing, China. AD - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. FAU - Wang, Cheng AU - Wang C AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, The National Health Commission of the People's Republic of China, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Li, Sisi AU - Li S AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, The National Health Commission of the People's Republic of China, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Zhang, Jie AU - Zhang J AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, The National Health Commission of the People's Republic of China, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Jin, Lei AU - Jin L AD - Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing, China. FAU - Tong, Mingkun AU - Tong M AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, The National Health Commission of the People's Republic of China, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Meng, Wenying AU - Meng W AD - Tongzhou Maternal and Child Health Care Hospital of Beijing, Beijing, China. FAU - Ren, Aiguo AU - Ren A AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, The National Health Commission of the People's Republic of China, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. FAU - Chen, Lei AU - Chen L AD - Department of Obstetrics and Gynecology, The Sixth Medical Center of People's Liberation Army (PLA) General Hospital, Beijing, China. AD - The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China. FAU - Jin, Lei AU - Jin L AD - Institute of Reproductive and Child Health, Peking University/Key Laboratory of Reproductive Health, The National Health Commission of the People's Republic of China, Beijing, China. AD - Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing, China. LA - eng PT - Journal Article DEP - 20220428 PL - Switzerland TA - Front Pediatr JT - Frontiers in pediatrics JID - 101615492 PMC - PMC9096220 OTO - NOTNLM OT - birth weight OT - folic acid OT - large-for-gestational-age OT - micronutrients OT - pregnancy OT - small-for-gestational-age OT - vitamin COIS- The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. EDAT- 2022/05/17 06:00 MHDA- 2022/05/17 06:01 PMCR- 2022/04/28 CRDT- 2022/05/16 04:35 PHST- 2021/12/28 00:00 [received] PHST- 2022/03/22 00:00 [accepted] PHST- 2022/05/16 04:35 [entrez] PHST- 2022/05/17 06:00 [pubmed] PHST- 2022/05/17 06:01 [medline] PHST- 2022/04/28 00:00 [pmc-release] AID - 10.3389/fped.2022.844404 [doi] PST - epublish SO - Front Pediatr. 2022 Apr 28;10:844404. doi: 10.3389/fped.2022.844404. eCollection 2022.