PMID- 35573949
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20220519
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 10
DP  - 2022
TI  - Intravenous Immunoglobulin Use in Hemolytic Disease Due to ABO Incompatibility to 
      Prevent Exchange Transfusion.
PG  - 864609
LID - 10.3389/fped.2022.864609 [doi]
LID - 864609
AB  - INTRODUCTION: Intravenous immunoglobulin (IVIG) has been widely used to treat the 
      hemolytic disease of the newborn (HDN). Although it has been shown that IVIG 
      treatment reduces the duration of phototherapy and hospitalization, the use of 
      IVIG in hemolytic disease due to ABO incompatibility has been controversial in 
      recent years. This study aimed to investigate the role of IVIG in the prevention 
      of exchange transfusion in infants with ABO HDN who presented with bilirubin 
      levels at or above the level of exchange transfusion. MATERIALS AND METHODS: This 
      study evaluated the data of infants with ABO HDN in the Turkish Neonatal Jaundice 
      Online Registry. The infants with ABO HDN who met the total serum bilirubin level 
      inclusion criteria (within 2-3 mg/dL of exchange transfusion or even above 
      exchange transfusion level) were included in the study according to the 
      guidelines from the American Academy of Pediatrics and the Turkish Neonatal 
      Society. All patients were managed according to the unit protocols recommended by 
      these guidelines and received light-emitting diode (LED) phototherapy. Infants 
      who only received LED phototherapy, and who received one dose of IVIG with LED 
      phototherapy were compared. RESULTS: During the study period, 531 term infants 
      were included in the study according to inclusion criteria. There were 408 cases 
      in the phototherapy-only group, and 123 cases in the IVIG group. The demographic 
      findings and the mean bilirubin and reticulocyte levels at admission were similar 
      between the groups (p > 0.05), whereas the mean hemoglobin level was slightly 
      lower in the IVIG group (p = 0.037). The mean age at admission was earlier, the 
      need for exchange transfusion was higher, and the duration of phototherapy was 
      longer in the IVIG group (p < 0.001, p = 0.001, and p < 0.001, respectively). The 
      rate of re-hospitalization and acute bilirubin encephalopathy (ABE) was higher in 
      the IVIG group (p < 0.001 and p = 0.01, respectively). CONCLUSION: In this study, 
      we determined that one dose of IVIG did not prevent an exchange transfusion nor 
      decrease the duration of phototherapy in infants, who had bilirubin levels near 
      or at exchange transfusion level, with hemolytic disease due to ABO 
      incompatibility.
CI  - Copyright (c) 2022 Okulu, Erdeve, Kilic, Olukman, Calkavur, Buyukkale, Cetinkaya, 
      Ulubas, Demirel, Hanta, Ertugrul, Gultekin, Tuncer, Demir, Bilgin, Narli, Yildiz, 
      Terek, Koroglu, Seren, Ozyazici, Ozdemir, Turgut, Narter, Akin, Ozyazici, 
      Zenciroglu, Asker, Gokmen, Salihli, Bulbul, Zubarioglu, Atasay, Koc and Turkish 
      Neonatal Society IVIG Study Group.
FAU - Okulu, Emel
AU  - Okulu E
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ankara 
      University, Ankara, Turkey.
FAU - Erdeve, Omer
AU  - Erdeve O
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ankara 
      University, Ankara, Turkey.
FAU - Kilic, Ilknur
AU  - Kilic I
AD  - Department of Neonatology, Atasehir Florence Nightingale Hospital, Istanbul, 
      Turkey.
FAU - Olukman, Ozgur
AU  - Olukman O
AD  - Department of Neonatology, Izmir Behcet Uz Children's Hospital, University of 
      Health Sciences, Izmir, Turkey.
FAU - Calkavur, Sebnem
AU  - Calkavur S
AD  - Department of Neonatology, Izmir Behcet Uz Children's Hospital, University of 
      Health Sciences, Izmir, Turkey.
FAU - Buyukkale, Gokhan
AU  - Buyukkale G
AD  - Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, 
      University of Health Sciences, Istanbul, Turkey.
FAU - Cetinkaya, Merih
AU  - Cetinkaya M
AD  - Department of Neonatology, Kanuni Sultan Suleyman Training and Research Hospital, 
      University of Health Sciences, Istanbul, Turkey.
FAU - Ulubas, Dilek
AU  - Ulubas D
AD  - Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and 
      Research Hospital, University of Health Sciences, Ankara, Turkey.
FAU - Demirel, Nihal
AU  - Demirel N
AD  - Department of Neonatology, Etlik Zubeyde Hanim Women's Health Teaching and 
      Research Hospital, University of Health Sciences, Ankara, Turkey.
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Yildirim 
      Beyazit University, Ankara, Turkey.
FAU - Hanta, Deniz
AU  - Hanta D
AD  - Department of Neonatology, Adana Delivery and Child Disease Hospital, Adana, 
      Turkey.
FAU - Ertugrul, Sabahattin
AU  - Ertugrul S
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Dicle 
      University, Diyarbakir, Turkey.
FAU - Gultekin, Nazli Dilay
AU  - Gultekin ND
AD  - Division of Neonatology, Department of Pediatrics, Meram Faculty of Medicine, 
      Necmettin Erbakan University, Konya, Turkey.
FAU - Tuncer, Oguz
AU  - Tuncer O
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, 
      Yuzuncuyil University, Van, Turkey.
FAU - Demir, Nihat
AU  - Demir N
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, 
      Yuzuncuyil University, Van, Turkey.
FAU - Bilgin, Leyla
AU  - Bilgin L
AD  - Department of Neonatology, Umraniye Research and Training Hospital, University of 
      Health Sciences, Istanbul, Turkey.
FAU - Narli, Nejat
AU  - Narli N
AD  - Neonatal Intensive Care Unit, Adana Metro Hospital, Adana, Turkey.
FAU - Yildiz, Duran
AU  - Yildiz D
AD  - Nenehatun Obstetrics and Gynecology Hospital, Erzurum, Turkey.
FAU - Terek, Demet
AU  - Terek D
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ege 
      University, Izmir, Turkey.
FAU - Koroglu, Ozge Altun
AU  - Koroglu OA
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ege 
      University, Izmir, Turkey.
FAU - Seren, Canan
AU  - Seren C
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ondokuz 
      Mayis University, Samsun, Turkey.
FAU - Ozyazici, Elif
AU  - Ozyazici E
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ondokuz 
      Mayis University, Samsun, Turkey.
FAU - Ozdemir, Ramazan
AU  - Ozdemir R
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Inonu 
      University, Malatya, Turkey.
FAU - Turgut, Hatice
AU  - Turgut H
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Inonu 
      University, Malatya, Turkey.
FAU - Narter, Fatma
AU  - Narter F
AD  - Department of Neonatology, Kartal Dr. Lutfi Kirdar Training and Research 
      Hospital, University of Health Sciences, Istanbul, Turkey.
FAU - Akin, Yasemin
AU  - Akin Y
AD  - Department of Neonatology, Kartal Dr. Lutfi Kirdar Training and Research 
      Hospital, University of Health Sciences, Istanbul, Turkey.
FAU - Ozyazici, Ahmet
AU  - Ozyazici A
AD  - Department of Neonatology, Dr. Sami Ulus Research and Training Hospital of 
      Women's and Children's Health and Diseases, Ankara, Turkey.
FAU - Zenciroglu, Aysegul
AU  - Zenciroglu A
AD  - Department of Neonatology, Dr. Sami Ulus Research and Training Hospital of 
      Women's and Children's Health and Diseases, Ankara, Turkey.
FAU - Asker, Huseyin Selim
AU  - Asker HS
AD  - Neonatal Intensive Care Unit, NCR Hospital, Gaziantep, Turkey.
FAU - Gokmen, Zeynel
AU  - Gokmen Z
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Konya 
      Hospital, Baskent University, Konya, Turkey.
FAU - Salihli, Musa
AU  - Salihli M
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Konya 
      Hospital, Baskent University, Konya, Turkey.
FAU - Bulbul, Ali
AU  - Bulbul A
AD  - Sisli Hamidiye Etfal Training and Research Hospital, University of Health 
      Sciences, Istanbul, Turkey.
FAU - Zubarioglu, Umut
AU  - Zubarioglu U
AD  - Sisli Hamidiye Etfal Training and Research Hospital, University of Health 
      Sciences, Istanbul, Turkey.
FAU - Atasay, Begum
AU  - Atasay B
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Ankara 
      University, Ankara, Turkey.
FAU - Koc, Esin
AU  - Koc E
AD  - Division of Neonatology, Department of Pediatrics, Faculty of Medicine, Gazi 
      University, Ankara, Turkey.
CN  - Turkish Neonatal Society IVIG Study Group
LA  - eng
PT  - Journal Article
DEP - 20220428
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC9095978
OTO - NOTNLM
OT  - ABO incompatibility
OT  - exchange transfusion
OT  - hemolytic disease of the newborn
OT  - intravenous immunoglobulin
OT  - light-emitting diode
OT  - phototherapy
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
FIR - Mert, Kurthan
IR  - Mert K
FIR - Yaman, Akan
IR  - Yaman A
FIR - Dizdar, Evrim Alyamac
IR  - Dizdar EA
FIR - Uras, Nurdan
IR  - Uras N
FIR - Hekimoglu, Berna
IR  - Hekimoglu B
FIR - Arisoy, Ayse Engin
IR  - Arisoy AE
FIR - Senel, Yasemin
IR  - Senel Y
FIR - Ozek, Eren
IR  - Ozek E
FIR - Ozdemir, Hulya
IR  - Ozdemir H
FIR - Tekgunduz, Kadir
IR  - Tekgunduz K
FIR - Caner, Ibrahim
IR  - Caner I
FIR - Tanriverdi, Sema
IR  - Tanriverdi S
FIR - Sarici, Dilek
IR  - Sarici D
FIR - Kislali, F Mehmet
IR  - Kislali FM
FIR - Aliefendioglu, Didem
IR  - Aliefendioglu D
FIR - Guzoglu, Nilufer
IR  - Guzoglu N
FIR - Aydemir, Cumhur
IR  - Aydemir C
FIR - Celik, Muhittin
IR  - Celik M
FIR - Karagol, Belma Saygili
IR  - Karagol BS
FIR - Bayraktar, Bilge
IR  - Bayraktar B
FIR - Sahin, Suzan
IR  - Sahin S
FIR - Hirfanoglu, Ibrahim Murat
IR  - Hirfanoglu IM
FIR - Acunas, Betul
IR  - Acunas B
FIR - Ozlu, Ferda
IR  - Ozlu F
FIR - Ecevit, Ayse
IR  - Ecevit A
FIR - Arcagok, Cengiz
IR  - Arcagok C
FIR - Tekin, Neslihan
IR  - Tekin N
FIR - Ergin, Hacer
IR  - Ergin H
FIR - Arslan, Selda
IR  - Arslan S
FIR - Coban, Asuman
IR  - Coban A
EDAT- 2022/05/17 06:00
MHDA- 2022/05/17 06:01
PMCR- 2022/04/28
CRDT- 2022/05/16 04:35
PHST- 2022/01/28 00:00 [received]
PHST- 2022/03/21 00:00 [accepted]
PHST- 2022/05/16 04:35 [entrez]
PHST- 2022/05/17 06:00 [pubmed]
PHST- 2022/05/17 06:01 [medline]
PHST- 2022/04/28 00:00 [pmc-release]
AID - 10.3389/fped.2022.864609 [doi]
PST - epublish
SO  - Front Pediatr. 2022 Apr 28;10:864609. doi: 10.3389/fped.2022.864609. eCollection 
      2022.